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ChemicalBook >> CAS DataBase List >>3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine

3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine

3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Structure
3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine structure
CAS No.
486460-20-2
Chemical Name:
3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
Synonyms
3-(TRIFLUOROMETHYL)-1,2,4-TRIAZOLO[4,3-A]-PYRAZINE;1,2,4-Triazolo[4,3-a]pyrazine, 3-(trifluoromethyl)-;3-(TRIFLUOROMETHYL)-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE,95% MIN(HPLC)
CBNumber:
CB4838863
Molecular Formula:
C6H3F3N4
Molecular Weight:
188.11
MDL Number:
MFCD09029664
MOL File:
486460-20-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-14 18:42:12
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3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Properties

Density 1.69±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka -2.40±0.30(Predicted)

3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AstaTech 52449 3-(TRIFLUOROMETHYL)-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE 95% 486460-20-2 0.25G $81 2026-04-30 Buy
AstaTech 52449 3-(TRIFLUOROMETHYL)-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE 95% 486460-20-2 1G $203 2026-04-30 Buy
AstaTech 52449 3-(TRIFLUOROMETHYL)-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE 95% 486460-20-2 5G $610 2026-04-30 Buy
Chem-Impex 29143 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine ≥98%(HPLC) 486460-20-2 100MG $58.39 2026-05-19 Buy
Chem-Impex 29143 3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine ≥98%(HPLC) 486460-20-2 250MG $105.36 2026-05-19 Buy
Product number Packaging Price Buy
52449 0.25G $81 Buy
52449 1G $203 Buy
52449 5G $610 Buy
29143 100MG $58.39 Buy
29143 250MG $105.36 Buy

3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Chemical Properties, Uses, Production

Uses

3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine can be used as reactant/reagent in synthetic preparation of 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for treatment or prevention of diabetes.

Synthesis

Ethanehydrazonoyl bromide, 2,2,2-trifluoro-N-2-pyrazinyl-

1447800-65-8

3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine

486460-20-2

General method: 10 mmol of compound 3 (CAS:1447800-65-8) was dissolved in 50 mL of toluene and 20 mmol of triethylamine was slowly added to the reaction system at room temperature with continuous stirring for 1 hour. The reaction process was monitored by thin layer chromatography (TLC). After the reaction was complete, the reaction mixture was slowly poured into 25 g of ice-water mixture, stirred thoroughly and left to stratify. The organic phase was separated and washed with 2 x 10 mL of cold water, followed by drying the organic phase with anhydrous sodium sulfate. Finally, the organic phase was concentrated under reduced pressure to give compound 4 in good yield.

References

[1] Letters in Organic Chemistry, 2013, vol. 10, # 5, p. 348 - 352

3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine synthesis

1447800-65-8
486460-20-2
Synthesis of 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution polyphosphoric acid Trifluoroacetic anhydride 2-Chloropyrazine 2-Hydrazinopyrazine
Ethanehydrazonoyl bromide, 2,2,2-trifluoro-N-2-pyrazinyl- Trifluoroacetic acid Toluene Triethylamine

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Preparation Products

Sitagliptin N-Boc IMpurity 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Suppliers

Global Suppliers ( 82)
Supplier Tel Email Country ProdList Advantage
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
China Langchem Inc. 0086-21-58956006 China 7798 57
Acorn PharmaTech Co., Ltd. 025-58395930 sales@acornpharma.com China 982 60
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3996 55
EnliPharma Technology Co., Ltd 0551-66399836 18955197623 sales@enlipharma.com China 1875 55
Cochemical Ltd. 029-86115547 17791676824 sales@cochemical.com China 3014 58
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189;18621755571 mychess007@163.com China 1994 55
Chengdu Aslee Biopharmaceuticals, Inc 028-85305008 02885305008 2306208234@qq.com China 1006 50
AN PharmaTech Co Ltd 86(21)68097365 sales@anpharma.net China 4875 55
Nanjing ERan Biological Pharmaceutical Co., Ltd. 13770809694 googlexu_0114@sina.com China 992 58
Supplier Advantage
Chemsky（shanghai）International Co.,Ltd. 50
China Langchem Inc. 57
Acorn PharmaTech Co., Ltd. 60
Chiba Pharmaceutical Science and technology Co, Ltd. 55
EnliPharma Technology Co., Ltd 55
Cochemical Ltd. 58
ShangHai KenEn Chemical Technology Co., Ltd. 55
Chengdu Aslee Biopharmaceuticals, Inc 50
AN PharmaTech Co Ltd 55
Nanjing ERan Biological Pharmaceutical Co., Ltd. 58

View Latest Price from 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-(Trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine pictures 2026-08-25 3-(Trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine
486460-20-2
 $1.60-6.60 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
3-(Trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine pictures 2026-07-14 3-(Trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine
486460-20-2
 1KG 98% 20Tons Shaanxi Dideu New Materials Co. Ltd
3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine pictures 2020-01-05 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
486460-20-2
 $1.00 1KG 99% 1kg-1000kg Career Henan Chemical Co

486460-20-2 (3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine) Related Search:

Terazosin hydrochloride Terazosin Doxazosin mesylate Doxazosin Tetramethylpyrazine
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3-(TRIFLUOROMETHYL)-1,2,4-TRIAZOLO[4,3-A]-PYRAZINE 3-(TRIFLUOROMETHYL)-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE,95% MIN(HPLC) 1,2,4-Triazolo[4,3-a]pyrazine, 3-(trifluoromethyl)- 486460-20-2 486460-53-7 C6H3F3N4