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Fmoc-L-valinol

Fmoc-L-valinol Structure
Fmoc-L-valinol structure
CAS No.
160885-98-3
Chemical Name:
Fmoc-L-valinol
Synonyms
FMOC-VALINOL;FMOC-VAL-OL;Fmoc-L-Val-ol;Fmoc-L-valinol;CAS:160885-98-3;N-FMOC-L-VALINOL;N-Fmoc-L-valinol,98%;N-ALPHA-FMOC-L-VALINOL;REF DUPL: Fmoc-L-Val-OH;FMOC-L-VALINOL USP/EP/BP
CBNumber:
CB5157477
Molecular Formula:
C20H23NO3
Molecular Weight:
325.4
MDL Number:
MFCD00235961
MOL File:
160885-98-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:53:14
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Fmoc-L-valinol Properties

Melting point 129-133 °C(lit.)
Boiling point 515.7±33.0 °C(Predicted)
Density 1.166±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form Solid
pka 11.40±0.46(Predicted)
Appearance White to off-white Solid
optical activity Consistent with structure
CAS DataBase Reference 160885-98-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

Fmoc-L-valinol price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 276999 Fmoc-L-valinol Asreported 160885-98-3 2g $375 2026-06-03 Buy
Usbiological 276999 Fmoc-L-valinol Asreported 160885-98-3 5g $668 2026-06-03 Buy
Usbiological 276999 Fmoc-L-valinol Asreported 160885-98-3 10g $948 2026-06-03 Buy
Usbiological 276999 Fmoc-L-valinol Asreported 160885-98-3 25g $1354 2026-06-03 Buy
Usbiological 238513 Fmoc-L-valinol 98+% (HPLC) ≥98%(HPLC) 1g $186 2026-06-03 Buy
Product number Packaging Price Buy
276999 2g $375 Buy
276999 5g $668 Buy
276999 10g $948 Buy
276999 25g $1354 Buy
238513 1g $186 Buy

Fmoc-L-valinol Chemical Properties, Uses, Production

Chemical Properties

White powder

Uses

FMOC-L-VALINOL is used as starting material for the synthesis of enantiopure β-amino acids. Used for the efficient synthesis of enantiopure tetrahydroisoquinoline compounds. An intermediate for the one-pot conversion of amino acid carbamate compounds into N-derived 2-azolidinone compounds.

Synthesis

FMOC-L-Valine

68858-20-8

FMOC-L-VALINOL

160885-98-3

GENERAL METHOD: To a tetrahydrofuran (THF, 10 mL) solution of Fmoc-L-valine (10 mmol) was added N,N-diisopropylethylamine (DIPEA, 11 mmol, 1.42 mL) and 50% propylphosphonic anhydride (T3P) in ethyl acetate (EtOAc) solution (20 mmol, 6.36 mL) at 0 °C, and the reaction was stirred mixture for about 10 minutes. Subsequently, an aqueous solution (0.3 mL) of sodium borohydride (NaBH4, 10 mmol, 388 mg) was slowly added to the reaction mixture at the same temperature and stirring was continued until the reaction was shown to be complete by thin layer chromatography (TLC). After completion of the reaction, the solvent was removed under reduced pressure by rotary evaporator and the crude product was extracted with ethyl acetate (EtOAc). The organic phase was washed sequentially with 5% aqueous citric acid (10 mL × 2), 5% aqueous sodium carbonate (Na2CO3) (10 mL × 2), water and saturated saline. Finally, the organic phase was dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford the target product (S)-(9H-fluoren-9-yl)methyl (1-hydroxy-3-methylbutan-2-yl)carbamate.

References

[1] Journal of Organic Chemistry, 2001, vol. 66, # 25, p. 8454 - 8462
[2] Tetrahedron Letters, 1999, vol. 40, # 23, p. 4395 - 4396
[3] Tetrahedron Letters, 2012, vol. 53, # 38, p. 5059 - 5063
[4] RSC Advances, 2014, vol. 4, # 87, p. 46947 - 46950
[5] Organic and Biomolecular Chemistry, 2011, vol. 9, # 11, p. 4182 - 4187

Fmoc-L-valinol Preparation Products And Raw materials

Raw materials

FMOC-L-Valine (S)-(+)-2-Amino-3-methyl-1-butanol 9-Fluorenylmethyl chloroformate Ethyl acetate Propylphosphonic anhydride
Sodium borohydride N,N-Diisopropylethylamine Water

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Preparation Products

Fmoc-L-valinol Suppliers

Global Suppliers ( 105)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
ChemPep, Inc. +1 (888) 615-9178 / (561) 791-8787 service@chempep.com United States 2138 57
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 22497 55
ApexBio Technology LLC +1-832-696-8203 info@apexbt.com United States 477 60
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
GL Biochem (Shanghai) Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57
Sichuan Kulinan Technology Co., Ltd 57
ChemPep, Inc. 57
9ding chemical ( Shanghai) Limited 55
ApexBio Technology LLC 60
Bide Pharmatech Ltd. 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58

View Latest Price from Fmoc-L-valinol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fmoc-L-Valinol pictures 2026-09-15 Fmoc-L-Valinol
160885-98-3
 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd

Fmoc-L-valinol Spectrum

FMOC-L-VALINOL(160885-98-3)1HNMR

160885-98-3 (Fmoc-L-valinol) Related Search:

Fmoc-Chg-OH 3-Methyl-1-butanol (S)-(+)-2-Amino-3-methyl-1-butanol Fmoc-N-methyl-L-isoleucine Fmoc-N-Me-Val-OH
FMOC-L-Valine Fmoc-L-tert-leucine Fmoc-Ile-OH Fmoc-L-valinol Fmoc-[15N]Val-OH
Fmoc-L-valine N-carboxy anhydride Fmoc-Ile-ol Fmoc-Ile-OPfp Fmoc-Pen(Acm)-OH Fmoc-Ile-N-carboxyanhydride
Fmoc-Val-OPfp Fmoc-Val-OSu Fmoc-Ile-OH-15N

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NALPHA-9-Fluorenylmethoxycarbonyl-(S)-2-amino-3-methyl-1-butanol (S)-2-(9-Fluorenylmethyloxycarbonyl)amino-3-methyl-1-butanol, N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-valinol (S)-2-(Fmoc-amino)-3-methyl-1-butanol, N-(9-Fluorenylmethoxycarbonyl)-L-valinol FMOC-(S)-2-AMINO-3-METHYL-1-BUTANOL FMOC-VAL-OL N-ALPHA-FMOC-L-VALINOL N-(9-FLUORENYLMETHOXYCARBONYL)-L-VALINOL N-FMOC-(S)-2-AMINO-3-METHYL-1-BUTANOL N-FMOC-L-VALINOL (S)-2-(FMOC-AMINO)-3-METHYL-1-BUTANOL (S)-(9H-fluoren-9-yl)methyl 1-hydroxy-3-methylbutan-2-ylcarbamate REF DUPL: Fmoc-L-Val-OH CarbaMic acid,N-[(1S)-1-(hydroxyMethyl)-2-Methylpropyl]-, 9H-fluoren-9-ylMethyl ester Fmoc-L-valinol≥ 98% (HPLC) Fmoc-L-Val-ol N-(1-hydroxy-3-methylbutan-2-yl)carbamic acid 9H-fluoren-9-ylmethyl ester N-Fmoc-L-valinol,98% FMOC-L-VALINOL USP/EP/BP CAS:160885-98-3 FMOC-VALINOL Fmoc-L-valinol 160885-98-3 C20H23NO3 FM - FZ Analytical Chromatography Product Catalog Analytical Standards Alphabetic peptides Amino Alcohols Fmoc-Amino acid series Amino Acids