Acethydrazide
- CAS No.
- 1068-57-1
- Chemical Name:
- Acethydrazide
- Synonyms
- ACETOHYDRAZIDE;ACETIC HYDRAZIDE;ACETYLHYDRAZINE;374;Acetyl hydrazide;ACETIC ACID HYDRAZIDE;Acetohydrazid;Acetyl drazide;acetylhydrazide;ENT-61241
- CBNumber:
- CB5266159
- Molecular Formula:
- C2H6N2O
- Molecular Weight:
- 74.08
- MDL Number:
- MFCD00007610
- MOL File:
- 1068-57-1.mol
- MSDS File:
- SDS
| Melting point | 58-68 °C (lit.) |
|---|---|
| Boiling point | 129 °C/18 mmHg (lit.) |
| Density | 1.0968 (rough estimate) |
| refractive index | 1.4264 (estimate) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Moist Crystals and Chunks |
| pka | 13.46±0.18(Predicted) |
| color | White |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| BRN | 506165 |
| InChI | 1S/C2H6N2O/c1-2(5)4-3/h3H2,1H3,(H,4,5) |
| InChIKey | OFLXLNCGODUUOT-UHFFFAOYSA-N |
| SMILES | CC(=O)NN |
| CAS DataBase Reference | 1068-57-1(CAS DataBase Reference) |
| FDA UNII | SK0DPC9098 |
| NIST Chemistry Reference | Acetic acid, hydrazide(1068-57-1) |
| EPA Substance Registry System | Acetic acid hydrazide (1068-57-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H341-H351 | |||||||||
| Precautionary statements | P201-P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 22-36/38-68-40-25 | |||||||||
| Safety Statements | 26-36-45-36/37 | |||||||||
| RIDADR | 1759 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | AI1225000 | |||||||||
| F | 3-8-10 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29280090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral Carc. 2 Eye Irrit. 2 Muta. 2 Skin Irrit. 2 |
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| Toxicity | LD50 oral in bird - wild: 42200ug/kg | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Acethydrazide price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A8309 | Acethydrazide 90% | 1068-57-1 | 5g | $57.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | A8309 | Acethydrazide 90% | 1068-57-1 | 25g | $108 | 2026-04-30 | Buy |
| TCI Chemical | A0789 | Acetohydrazide >98.0%(GC)(T) | 1068-57-1 | 25g | $81 | 2026-04-30 | Buy |
| TCI Chemical | A0789 | Acetohydrazide >98.0%(GC)(T) | 1068-57-1 | 100g | $199 | 2026-04-30 | Buy |
| Usbiological | 162503 | Acetohydrazide | 1068-57-1 | 1g | $340 | 2026-06-03 | Buy |
Acethydrazide Chemical Properties, Uses, Production
Description
Acethydrazide is an essential organic intermediate mainly used to synthesize nifuratrone in the pharmaceutical industry. It belongs to the hydrazine/hydrazone group, which plays an important role in the anti-microbial activity. Recently, Acethydrazide has gained significant importance due to its anti-tuberculosis activity. A disease caused by parasites represents a major world health problem with limited therapeutic options. Acethydrazide was synthesized from the reaction between ethyl acetate and hydrazine hydrate in methanol solvent and purified[1-2].
Chemical Properties
White moist crystals and chunks
Uses
Acetic hydrazide is used as an antibiotic for the treatment of mycobacterium tuberculosis. It is also involved in the preparation of sunitinib b reacting with 5-fluoroisatin. Further, it inhibits mycolic acid biosynthesis. It serves as an important intermediate in organic synthesis such as nitric furosemide Long (nifuratrone) in medicine.
Acethydrazide can be used in the synthesis of (E)-N′-(2-hydroxybenzylidene)acetohydrazide, an ONO pincer ligand.
Definition
ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group.
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. Mutation data reported. Exposure can cause hemolysis and liver damage. See also PHENYLHYDRAZINE. When heated to decomposition it emits toxic fumes of NOX,.
Synthesis
A kind of preparation method of acethydrazide include the following steps: Under nitrogen protection, by acetic acid, hydrazine hydrate It is put into catalyst in the reaction kettle with rectifying column, opens stirring, be heated to reflux, after steam enters rectifying column, Vapor are produced in tower top temperature for 98°C~100°C, when reaction 4~6 is small at a reflux temperature, when rectifying tower top frozen-free current Reaction terminates after going out, and continues heating distillation, and the acetic acid and hydrazine hydrate of reaction are had neither part nor lot in 100°C~120°C extraction of tower top temperature, After acetic acid and hydrazine hydrate are all steamed, liquid in kettle is poured out into filtering while hot, filtrate is through crystallisation by cooling, pure water, very Acethydrazide finished product is obtained after sky is dry.
Purification Methods
Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.]
References
[1] S. Nzikayel, A. Ec, Akpan Ij. “Synthesis, FTIR and Electronic Spectra Studies of Metal (II) Complexes of Acethydrazide Derivative.” Medicinal Chemistry 8 1 (2018): 26–28.
[2] S. Pakdehi, A. S. Moghaddam, M. Sohrabi. “Liquid phase hydrogenation of acethydrazone to N’-methyl acethydrazide over Pd/γ-Al2O3 catalyst.” Brazilian Journal of Chemical Engineering 27 1 (2010): 145–152.
Acethydrazide Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Zhihe Fine Chemical Co., Ltd. | 15965280885; 13854654186 | 194354110@qq.com | China | 6 | 58 |
| Anhui Enrich Biotechnology Co., Ltd | 17730023384 | China | 40 | 58 | |
| Yangzhou Aoxin Chemical Co., Ltd | 0514-87754778 13901446058 | sales@aochem.com | China | 69 | 66 |
| JinanGongchuang Pharmaceutical Technology Co. Ltd.. | 88065293 13287783460 | 3166282224@qq.com | China | 40 | 58 |
| Jinan Wald Chemical Co., Ltd. | 0531-88773586 13210588999 | 304264064@qq.com | China | 192 | 58 |
| Jiangyin Soteng Biotechnology Co., Ltd. | 0510-86686637 13861630217 | marketingb@suntonchem.com | China | 16 | 58 |
| Shaanxi Zhong Zhi Biao Pin Pharmaceutical technology Co., LTD | 029-89239927 18009291534 | 18009291534@163.com | China | 376 | 58 |
| Hubei Hanqing Biopharmaceutical Technology Co., Ltd | 15827479330 | 3583890861@qq.com | China | 4992 | 58 |
| Tianjin Zhongxin Chemtech Co., Ltd. | 022-66880623 | sales@tjzxchem.com | China | 612 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
Related articles
- The reactivity of Acethydrazide
- Acetohydrazide is a carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group and it is a ....
- Oct 24,2019
View Latest Price from Acethydrazide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Acethydrazide
1068-57-1
|
1kg | 99% | 1000mt/year | Jinan Finer Chemical Co., Ltd | ||
 |
2026-09-16 | Acethydrazide
1068-57-1
|
$80.00-99.00 | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-09-02 | Acethydrazide
1068-57-1
|
$1.00-50.00 | 1kg | 99 | Henan Fengda Chemical Co., Ltd |
-
- Acethydrazide
1068-57-1
- $0.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Acethydrazide
1068-57-1
- $80.00-99.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Acethydrazide
1068-57-1
- $1.00-50.00
- 99
- Henan Fengda Chemical Co., Ltd
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