4-Aminohippuric acid
- CAS No.
- 61-78-9
- Chemical Name:
- 4-Aminohippuric acid
- Synonyms
- PAH;P-AMINOHIPPURIC ACID;POLYNUCLEAR AROMATIC HYDROCARBONS;paha;Nefrotest;N-glycine;Aminohippuric;pah(aminoacid);AKOS BBS-00006940;p-amino-hippuricaci
- CBNumber:
- CB5348161
- Molecular Formula:
- C9H10N2O3
- Molecular Weight:
- 194.19
- MDL Number:
- MFCD00007890
- MOL File:
- 61-78-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Aminohippuric Acid pharmaceutical secondary standard, certified reference material | PHR3174 | 500MG | $203 |
| 4-Aminohippuric acid for synthesis | 8.14621 | 25g | $209 |
| p-Aminohippuric acid ≥98.0% (T) | 08090 | 50g | $387 |
| 4-Aminohippuric Acid >99.0%(T) | A0313 | 10g | $204 |
| 4-Aminohippuric Acid >99.0%(T) | A0313 | 25g | $408 |
| More product size | |||
| Melting point | 199-200 °C (dec.)(lit.) |
|---|---|
| Boiling point | 330.62°C (rough estimate) |
| bulk density | 380kg/m3 |
| Density | 1.356 |
| refractive index | 1.5600 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | DMF: 33 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 20 mg/ml |
| form | Crystalline Powder |
| pka | pKa 3.8 (Uncertain) |
| color | Off-white to grayish |
| PH | 3.0-3.5 (20g/l, H2O, 20℃) |
| Water Solubility | Soluble in alcohol, chloroform, benzene, and acetone. Insoluble in water, ether, carbon, and tetrachloride. |
| Merck | 14,442 |
| BRN | 1213676 |
| Major Application | cell analysis |
| InChI | 1S/C9H10N2O3/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13/h1-4H,5,10H2,(H,11,14)(H,12,13) |
| InChIKey | HSMNQINEKMPTIC-UHFFFAOYSA-N |
| SMILES | Nc1ccc(cc1)C(=O)NCC(O)=O |
| CAS DataBase Reference | 61-78-9(CAS DataBase Reference) |
| FDA UNII | Y79XT83BJ9 |
| NCI Dictionary of Cancer Terms | PAH |
| EPA Substance Registry System | P-Aminohippuric acid (61-78-9) |
| UNSPSC Code | 41116107 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-9-23 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazardous Substances Data | 61-78-9(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
4-Aminohippuric acid price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR3174 | Aminohippuric Acid pharmaceutical secondary standard, certified reference material | 61-78-9 | 500MG | $203 | 2026-03-19 | Buy |
| Sigma-Aldrich | 8.14621 | 4-Aminohippuric acid for synthesis | 61-78-9 | 25g | $209 | 2026-03-19 | Buy |
| Sigma-Aldrich | 08090 | p-Aminohippuric acid ≥98.0% (T) | 61-78-9 | 50g | $387 | 2023-01-07 | Buy |
| TCI Chemical | A0313 | 4-Aminohippuric Acid >99.0%(T) | 61-78-9 | 10g | $204 | 2026-03-19 | Buy |
| TCI Chemical | A0313 | 4-Aminohippuric Acid >99.0%(T) | 61-78-9 | 25g | $408 | 2026-03-19 | Buy |
4-Aminohippuric acid Chemical Properties,Uses,Production
Description
4-Aminohippuric acid is a substrate for various renal transporters that has been used in the study of anion uptake in the kidney. It is a substrate for organic anion transporter 1 (OAT1; Km = 14.3 μM in X. laevis oocytes), the human inorganic phosphate transporter (NPT1; Km = 2.66 mM in HEK293 cells), and apical multidrug resistance protein (MDR2; Km = 880 μM in HEK293 cells). 4-Aminohippuric acid is a glycine amide form of 4-aminobenzoic acid . Formulations containing 4-aminohippuric acid have been used as markers to determine renal plasma flow.
Chemical Properties
off-white to greyish crystalline powder
Uses
muscle relaxant (smooth)
Uses
4-Aminohippuric Acid is used in the measurement of renal plasma flow as a diagnostic tool which may be applied towards kidney disorders.
Uses
p-Aminohippuric acid has been used as infusions to measure plasma flow.
Definition
ChEBI: P-aminohippuric acid is an N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow. It has a role as a Daphnia magna metabolite. It is a conjugate acid of a p-aminohippurate.
General Description
Renal tubules secretes para amino hippuric acid/PAH.
Biochem/physiol Actions
Para-aminohippuric acid(PAH) is used as a marker in nutrition studies to measure the flow of blood in pigs, which inturn helps to determine the portal-drained viscera (PDV) flux of nutrients.
Synthesis
4-Aminohippuric acid is prepared by reacting p-nitrobenzoyl chloride with glycine, followed by reducing the p-nitro group with tin and hydrochloric acid.
Purification Methods
Crystallise the acid from H2O. It is soluble in organic solvents. [Cohen & McGilvery J Biol Chem 169 119 1945, 171 121 1947, Meunzen et al. J Biol Chem 26 469 1926, Beilstein 14 III 1069, 14 IV 1152.]
References
[1] B. ZMBOVA . Synthesis of p-aminohippuric acid analog and its labeling by technetium-99m[J]. International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1989, 40 3: Pages 225-234. DOI:10.1016/0883-2889(89)90152-4.
[2] W P DEISS P P C. Studies in para-aminohippuric acid synthesis in the human: its application as a liver function test.[J]. Journal of Clinical Investigation, 1950, 29 8: 1014-1020. DOI:10.1172/JCI102332.
[3] M. SHEAT M. M Zenab F Saeed. Synthesis of Some of Azo, Triazines and Schiff Bases Compounds from 4-Aminohippuric Acid[J]. Journal of Education Science, 2009, 47 1: 1-8. DOI:10.33899/edusj.2009.57930.
[4] T SEKINE. Expression cloning and characterization of a novel multispecific organic anion transporter.[J]. The Journal of Biological Chemistry, 1997, 272 30: 18526-18529. DOI:10.1074/jbc.272.30.18526.
[5] HIROSHI UCHINO . p-Aminohippuric Acid Transport at Renal Apical Membrane Mediated by Human Inorganic Phosphate Transporter NPT1[J]. Biochemical and biophysical research communications, 2000, 270 1: Pages 254-259. DOI:10.1006/bbrc.2000.2407.
4-Aminohippuric acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 | 16728589@qq.com | CHINA | 272 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20125 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32469 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18867 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52722 | 58 |
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View Lastest Price from 4-Aminohippuric acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-13 | 4-Aminohippuric Acid
61-78-9
|
US $47.00 / mg | 98.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-13 | 4-Aminohippuric Acid
61-78-9
|
US $47.00 / mg | 98.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-01 | 4-Aminohippuric acid
61-78-9
|
US $0.00 / kg | 1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- 4-Aminohippuric Acid
61-78-9
- US $47.00 / mg
- 98.89%
- TargetMol Chemicals Inc.
-
- 4-Aminohippuric Acid
61-78-9
- US $47.00 / mg
- 98.89%
- TargetMol Chemicals Inc.
-
- 4-Aminohippuric acid
61-78-9
- US $0.00 / kg
- 98%
- Shaanxi Dideu New Materials Co. Ltd
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