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(S)-1-N-Boc-2-methylpiperazine

(S)-1-N-Boc-2-methylpiperazine Structure
(S)-1-N-Boc-2-methylpiperazine structure
CAS No.
169447-70-5
Chemical Name:
(S)-1-N-Boc-2-methylpiperazine
Synonyms
tert-butyl (S)-2-methylpiperazine-1-carboxylate;(S)-TERT-BUTYL 2-METHYLPIPERAZINE-1-CARBOXYLATE;(R)-TERT-BUTYL 2-METHYLPIPERAZINE-1-CARBOXYLATE;(S)-1-Boc-2-methl-piperazine;(S)-N-Boc-2-methylpiperazine;(R)-2-METHYL-1-BOC-PIPERAZINE;1-Boc-2-(S)-Methyl Piperazine;(S)-1-Boc-2-methyl-piperazine;(S)-N1-BOC-2-METHYLPIPERAZINE;(S)-1-N-BOC-2-METHYL PIPERAZINE
CBNumber:
CB9714476
Molecular Formula:
C10H20N2O2
Molecular Weight:
200.28
MDL Number:
MFCD01862121
MOL File:
169447-70-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:50:56
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(S)-1-N-Boc-2-methylpiperazine Properties

Melting point 43.0 to 47.0 °C
Boiling point 268.7±15.0 °C(Predicted)
Density 0.997±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
form powder to crystal
pka 8.49±0.40(Predicted)
color White to Almost white
optical activity Consistent with structure
InChI InChI=1S/C10H20N2O2/c1-8-7-11-5-6-12(8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m0/s1
InChIKey DATRVIMZZZVHMP-QMMMGPOBSA-N
SMILES N1(C(OC(C)(C)C)=O)CCNC[C@@H]1C
CAS DataBase Reference 169447-70-5(CAS DataBase Reference)
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P271
RIDADR  UN3077
HS Code  2933599590

(S)-1-N-Boc-2-methylpiperazine price More Price(78)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B4846 (S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine >98.0%(GC)(T) 169447-70-5 1g $50 2026-04-30 Buy
TCI Chemical B4846 (S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine >98.0%(GC)(T) 169447-70-5 5g $174 2026-04-30 Buy
Usbiological 285042 S-1-N-Boc-2-methylpiperazine 169447-70-5 5g $410 2026-06-03 Buy
Usbiological 285042 S-1-N-Boc-2-methylpiperazine 169447-70-5 10g $631 2026-06-03 Buy
Usbiological 285042 S-1-N-Boc-2-methylpiperazine 169447-70-5 25g $1125 2026-06-03 Buy
Product number Packaging Price Buy
B4846 1g $50 Buy
B4846 5g $174 Buy
285042 5g $410 Buy
285042 10g $631 Buy
285042 25g $1125 Buy

(S)-1-N-Boc-2-methylpiperazine Chemical Properties, Uses, Production

Uses

(S)-1-N-Boc-2-methylpiperazine is used in the preparation of pyrazolo[3,4-b]pyridine dual pharmacophores as PDE4-muscarinic antagonists.

Synthesis

A solution of (S)-2-methyl piperazine (2 g, 20 mmol) in THF (200 ml_) was mixed with nBuLi (25 ml, 1.6 M in hexanes, 40 mmol) at rt. The solution was stirred for 30 minutes before TBDMSCI (3.04 g, 20 mmol) was added. The mixture was stirred for 1 hour and then (Boc)2O (5.2 g, 24 mmol) was added to the solution. After 1 hour, the solution was diluted with H2O (50 ml). The organic layer was separated, washed with brine (50 mL), dried over Na2SO4, and concentrated EPO under vacuum. Finally, (S)-1-N-Boc-2-methylpiperazine was obtained after purification.(S)-1-N-Boc-2-methylpiperazine

References

[1] Patent: WO2006/55553, 2006, A2. Location in patent: Page/Page column 36; 37
[2] Journal of Organic Chemistry, 1995, vol. 60, # 13, p. 4177 - 4183

(S)-1-N-Boc-2-methylpiperazine synthesis

24424-99-5
169447-70-5
Synthesis of (S)-1-N-Boc-2-methylpiperazine from Di-tert-butyl dicarbonate

(S)-1-N-Boc-2-methylpiperazine Preparation Products And Raw materials

Raw materials

(S)-1-Benzyl-3-methylpiperazine-2,5-dione (S)-tert-Butyl 4-benzyl-2-methylpiperazine-1-carboxylate (S)-Methyl 2-(2-chloroacetamido) propanoate 2-(S)-Methylpiperazine-1,4-dicarboxylic acid 4-benzyl ester 1-ter-butyl ester (S)-(+)-2-Methylpiperazine
(S)-2-Methyl-4-benzylpiperazine Di-tert-butyl dicarbonate tert-Butyldimethylsilyl chloride n-Butyllithium Tetrahydrofuran

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Preparation Products

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(S)-1-N-Boc-2-methylpiperazine Suppliers

Global Suppliers ( 257)
Supplier Tel Email Country ProdList Advantage
Shanghai Boc Chemical Co.,Ltd 021-34975603-808 18721111801 sales@bocpharma.com China 991 64
Chengdu Firster Pharmaceutical Co., Ltd. 028-87078428 028-87074958 chengzhenyong@cdfirster.com China 2580 60
Purest Pharmaceuticl （Xi’an) Co,.LTD +86-13893405577; 13893405577 12829054@qq.com China 83 58
Shanxi Xinsheng Biotechnology Co., Ltd 15835826763 997855689@qq.com China 111 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Changzhou Huanling Chemical Co., Ltd. 89803005 18206112582 info@huanlingchem.com China 983 68
Sichuan Guanghan Bio-Tech Co., Ltd +86-28-86127071 info@sino-produce.com China 400 66
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Supplier Advantage
Shanghai Boc Chemical Co.,Ltd 64
Chengdu Firster Pharmaceutical Co., Ltd. 60
Purest Pharmaceuticl （Xi’an) Co,.LTD 58
Shanxi Xinsheng Biotechnology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Capot Chemical Co., Ltd 66
Changzhou Huanling Chemical Co., Ltd. 68
Sichuan Guanghan Bio-Tech Co., Ltd 66
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62

View Latest Price from (S)-1-N-Boc-2-methylpiperazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-1-N-Boc-2-methylpiperazine pictures 2026-09-16 (S)-1-N-Boc-2-methylpiperazine
169447-70-5
 $73.00-607.00 25g 0.99 10 Shanghai UCHEM Inc.
(S)-1-N-Boc-2-methylpiperazine pictures 2019-08-09 (S)-1-N-Boc-2-methylpiperazine
169447-70-5
 $8.80 1KG 97%-99% 100kg Career Henan Chemical Co

(S)-1-N-Boc-2-methylpiperazine Spectrum

(S)-1-N-Boc-2-methylpiperazine(169447-70-5)1HNMR

169447-70-5 ((S)-1-N-Boc-2-methylpiperazine) Related Search:

tert-Butyl peroxybenzoate 1-Methylpiperazine N-Methyl-2-pyrrolidone 1,2-Dimethylhydrazine Dihydrochloride N-Methylolacrylamide
2-Methylpiperazine Diisobutyl phthalate Butylparaben 1-Methylimidazole N-Methyldiethanolamine
N-Methylacetamide Isobutyl chloroformate (S)-1-Boc-2-isopropylpiperazine D-1-N-Boc-prolinamide 1-Benzhydrylpiperazine
(S)-2-Thiocarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester (S)-(+)-N-Tboc-2-methylpiperidine (S)-tert-butyl 4-aMinoazepane-1-carboxylate

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1-Boc-2-(S)-Methyl Piperazine TERT-BUTYL (2S)-2-METHYPIPERAZINE-1-CARBOXYLATE (R)-2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-2-METHYL-1-BOC-PIPERAZINE (S)-1-N-BOC-2-METHYL PIPERAZINE (S)-2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-TERT-BUTYL 2-METHYLPIPERAZINE-1-CARBOXYLATE (S)-1-Boc-2-methyl-piperazine Tert-Butyl2(S)-methylpiperazine-1-carboxylate 2-S-Methyl-piperazine-1-carboxylic acid tert-butyl ester (S)-1-N-Boc-2-Methylpiperizine tert-butyl 2(S)-methylpiperazine-1-carboxylate (S)-N1-BOC-2-METHYLPIPERAZINE (S)-1-Boc-2-methl-piperazine (S)-1-N-Boc-2-Methylpiperazine ,98% (2S)-2-Methylpiperazine, N1-BOC protected 98% tert-Butyl (2S)-2-methylpiperazine-1-carboxylate (2S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine (2S)-2-Methyl-1-piperazinecarboxylic Acid 1,1-DiMethylethyl Ester tert-Butyl (2S)-2-Methylpiperazine-1-carboxylate 1-Piperazinecarboxylic acid, 2-methyl-, 1,1-dimethylethyl ester, (2S)- (S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine (2S)-2-Methylpiperazine,N1-BOCprotected98% (S)-N-Boc-2-methylpiperazine (S)-N-Boc-2-methylpiperazine,98%e.e. (S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine (S)-1-(tert-Butoxycarbonyl)-2-methylpiperazine > (S)-2-Methyl-1-piperazinecarboxylic Acid tert-Butyl Ester tert-Butyl (S)-2-Methyl-1-piperazinecarboxylate 1,1-Dimethylethyl (2S)-2-methyl-1-piperazinecarboxylate (S)-TERT-BUTYL 2-METHYLPIPERAZINE-1-CARBOXYLATE tert-butyl (S)-2-methylpiperazine-1-carboxylate 169447-70-5 170033-47-4 Chiral Reagents Heterocycles pharmacetical Piperaizine