2-Chloroquinoline
- CAS No.
- 612-62-4
- Chemical Name:
- 2-Chloroquinoline
- Synonyms
- 2CQ;2-chloro-quinolin;2-CHLOROQUINOLINE;Quinoline2-chloro-;2-Chloroquinoline,99%;2-Chloroquinoline >2-Chloroquinoline, 98%+;2-Chloroquinoline ,99.70%;2-Chloroquinoline, 99% 5GR;2-Chloroquinoline, 99% 1GR
- CBNumber:
- CB5403688
- Molecular Formula:
- C9H6ClN
- Molecular Weight:
- 163.6
- MDL Number:
- MFCD00006741
- MOL File:
- 612-62-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 34-37 °C (lit.) |
|---|---|
| Boiling point | 266-267 °C (lit.) |
| Density | 1.23 g/mL at 25 °C (lit.) |
| refractive index | 1.6342 (estimate) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | methanol: 0.1 g/mL, clear |
| form | Crystalline Powder, Crystals and/or Chunks or Fused Mass |
| pka | 0.41±0.40(Predicted) |
| color | White to yellow |
| Water Solubility | Insoluble |
| BRN | 112561 |
| InChI | 1S/C9H6ClN/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H |
| InChIKey | OFUFXTHGZWIDDB-UHFFFAOYSA-N |
| SMILES | Clc1ccc2ccccc2n1 |
| CAS DataBase Reference | 612-62-4(CAS DataBase Reference) |
| FDA UNII | UX7RIN8GEW |
| NIST Chemistry Reference | Quinoline, 2-chloro-(612-62-4) |
| EPA Substance Registry System | Quinoline, 2-chloro- (612-62-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VB2320000 | |||||||||
| F | 8 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29334900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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2-Chloroquinoline price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C70401 | 2-Chloroquinoline 99% | 612-62-4 | 5g | $271 | 2026-04-30 | Buy |
| Sigma-Aldrich | C70401 | 2-Chloroquinoline 99% | 612-62-4 | 1g | $89.5 | 2023-06-20 | Buy |
| TCI Chemical | C0282 | 2-Chloroquinoline >98.0%(GC) | 612-62-4 | 5g | $69 | 2026-04-30 | Buy |
| TCI Chemical | C0282 | 2-Chloroquinoline >98.0%(GC) | 612-62-4 | 25g | $272 | 2026-04-30 | Buy |
| Usbiological | 267706 | 2-Chloroquinoline ≥99%(GC) | 612-62-4 | 10g | $333 | 2026-06-03 | Buy |
2-Chloroquinoline Chemical Properties, Uses, Production
Chemical Properties
white to yellowish crystals, powder, chunks or
Uses
2-Chloroquinoline is an intermediate used in the synthesis of various compounds that exhibits antifungal properties.
Uses
2-Chloroquinoline is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. It reacts with benzotriazole, followed by cyclization with loss of nitrogen, gives the indolo[2,3-b]quinoline ring system for use in novel cytotoxic DNA topoisomerase II inhibitors.
Synthesis Reference(s)
The Journal of Organic Chemistry, 67, p. 7884, 2002 DOI: 10.1021/jo016196i
Synthesis, p. 1013, 1987 DOI: 10.1055/s-1987-28152
Synthesis
In a dry four-necked reaction flask add 20mL of dichloromethane, add 2.175g (15mmol) of quinoline N-oxide, turn on the stirring, cool to 0C add 3.035g (30mmol) of triethylamine, the temperature of the system is controlled below -5C, add 0.438g (7.5mmol) of sodium chloride, 1.305g (0.75mmol) of sodium conidiosulfate and 0.136g (0.6mmol) benzyltriethylammonium chloride, continue to lower the temperature to below -10 , dropwise add 8mL of dichloromethane solution containing 2.222g (7.5mmol) bis (trichloromethyl) carbonate, and the reaction was carried out at this temperature for 6h. At the end of the reaction, the reaction was quenched by adding 10mL of deionized water, the layers were separated and the organic phase was washed with 10mL of a 10% sodium hydroxide solution, then with 10mL of deionized water, and the organic phase was washed with 10mL of 10% sodium hydroxide solution. The organic phase was washed with 10 mL of 10% sodium hydroxide solution, then washed with 10 mL of deionized water, and finally the aqueous phase was extracted with (15 mL*2) dichloromethane, and the organic layers were combined, dried with anhydrous MgSO4, and concentrated to obtain the crude product. After purification by column chromatography, 1.501g of product was obtained with 61.4% yield.
Purification Methods
Purify it by crystallisation of its picrate to constant melting point (123-124o) from *benzene, regenerating the base and distilling it under vacuum [Cumper et al. J Chem Soc 1183 1962]. 2-Chloroquinoline can be crystallised from EtOH. Its picrate has m 123-124o (from EtOH). [Beilstein 20 H 359, 20/7 V 312.]
2-Chloroquinoline Preparation Products And Raw materials
Raw materials
1of5
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Fanbo Pharmaceutical Technology Co., Ltd. | 15588346797 | fanbomedical@163.com | China | 628 | 58 |
| Zhengzhou Huiju Chemical Co., Ltd. | 0371-55900031 18137872243 | 3927209986@qq.com | China | 9999 | 55 |
| Hangzhou Sulfuchem Material Technology Co., Ltd. | 0571-86113725 15372021306 | sales@sulfuchem.com | China | 969 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 2-Chloroquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | Chloroquinoline
612-62-4
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 2-Chloroquinoline
612-62-4
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2026-06-30 | 2-Chloroquinoline
612-62-4
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- Chloroquinoline
612-62-4
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 2-Chloroquinoline
612-62-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Chloroquinoline
612-62-4
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
