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Fmoc-Leu-OH

Fmoc-Leu-OH Structure
Fmoc-Leu-OH structure
CAS No.
35661-60-0
Chemical Name:
Fmoc-Leu-OH
Synonyms
FMOC-LEU-OH;FMOC-LEU;FMOC-L-LEU-OH;FMOC-L-LEU;(((9H-fluoren-9-yl)methoxy)carbonyl)-L-leucine;FMOC-LEUCINE;FMOC-L-LEUCINE;(S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-4-Methylpentanoic acid;N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-LEUCINE;L-LEUCINE-N-FMOC
CBNumber:
CB5477829
Molecular Formula:
C21H23NO4
Molecular Weight:
353.41
MDL Number:
MFCD00037133
MOL File:
35661-60-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-20 20:20:01
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Fmoc-Leu-OH Properties

Melting point 152-156 °C(lit.)
alpha -26 º (c=1,DMF 24 ºC)
Boiling point 486.83°C (rough estimate)
Density 1.2107 (rough estimate)
refractive index -25 ° (C=1, DMF)
storage temp. Store below +30°C.
solubility DMF (Slightly), DMSO (Slightly)
form Solid
pka 3.91±0.21(Predicted)
color White to Off-White
optical activity [α]20/D 25±2°, c = 1% in DMF
BRN 2178254
Stability Hygroscopic
Major Application peptide synthesis
InChI 1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/t19-/m0/s1
InChIKey CBPJQFCAFFNICX-IBGZPJMESA-N
SMILES CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
CAS DataBase Reference 35661-60-0(CAS DataBase Reference)
FDA UNII KF18F70UF3
UNSPSC Code 12352209
NACRES NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36/37/39-27-26
WGK Germany  3
HS Code  2924 29 70
Storage Class 11 - Combustible Solids
REACH Registrations Active
NFPA 704
1
1 0

Fmoc-Leu-OH price More Price(114)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.52011 Fmoc-Leu-OH Novabiochem? 35661-60-0 25g $33.8 2026-04-30 Buy
Sigma-Aldrich 8.52011 Fmoc-Leu-OH Novabiochem? 35661-60-0 100g $83 2026-04-30 Buy
Sigma-Aldrich 8.52011 Fmoc-Leu-OH Novabiochem? 35661-60-0 250g $179 2026-04-30 Buy
Sigma-Aldrich 8.52011 Fmoc-Leu-OH Novabiochem® 35661-60-0 500 g $328 2026-04-30 Buy
Sigma-Aldrich 8.52011 Fmoc-Leu-OH Novabiochem? 35661-60-0 1kg $588 2026-04-30 Buy
Product number Packaging Price Buy
8.52011 25g $33.8 Buy
8.52011 100g $83 Buy
8.52011 250g $179 Buy
8.52011 500 g $328 Buy
8.52011 1kg $588 Buy

Fmoc-Leu-OH Chemical Properties, Uses, Production

Description

Fmoc-Leu-OH is isomeric with Fmoc-Ile-OH. Like isoleucine, leucine has branching in the sidechain. The branching is at the gamma carbon instead of the beta carbon as in isoleucine. It is used in chemical and peptide syntheses.

Chemical Properties

white to light yellow crystal powde

Uses

Fmoc-L-Leu-OH, is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs.

Application

Fmoc-Leu-OH can be used as a reactant to synthesize:
Various oligopeptides by reacting with functionalized α-amino acid hydrochloride salts.
A cyclic depsipeptide sansalvamide A, a natural product found in marine fungus.
Streptocidin AD, decapeptide antibiotics naturally found in Streptomycessp. Tü 6071.
Coumaroyl dipeptide amide that can be used for cosmetic applications.

Preparation

Fmoc-L-leucine is prepared by reacting L-leucine with 9-fluorenylmethoxycarbonyl chloride.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Biological Activity

Anti-inflammatory agent; increases intracellular Ca 2+ levels. PPARγ ligand that induces insulin sensitization, but not adipogenesis.

Synthesis

FMOC-L-LEUCYL CHLORIDE

103321-59-1

Fmoc-Leu-OH

35661-60-0

Fmoc-Leu-NH2

139551-97-6

The general procedure for the synthesis of Fmoc-L-leucine and compound (CAS:139551-97-6) using compound (CAS:103321-59-1) as starting material was as follows:Example 22 Synthesis of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine amide (NPC 15528). To a 10 mL THF solution containing 3.5 mL (10 mmol) of N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine chloride, 1.26 mL (20 mmol) of a 29.6% ammonia solution was slowly added at room temperature. The reaction mixture was stirred for 30 min, then diluted with 100 mL of water and extracted with ethyl acetate (5 x 20 mL). The organic layers were combined and washed sequentially with 10% potassium carbonate solution, water and brine, then dried and concentrated. The product was recrystallized by ethanol to give 1.26 g (36% yield) of N-(9-fluorenylmethoxycarbonyl)-L-leucine amide as a colorless solid with a melting point of 79-80 °C.

References

[1] Patent: US5079260, 1992, A

Fmoc-Leu-OH Preparation Products And Raw materials

Raw materials

FMOC-b-Ala-OH Fmoc-L-leucyl chloride Water Tetrahydrofuran Ethanol
Ammonia

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Preparation Products

Indolicidin ANGIOTENSIN I, HUMAN MELITTIN Fmoc-L-beta-homoleucine Fmoc-Leu-ONp
Fmoc-L-leucyl chloride Fmoc-N-methyl-L-leucine

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Fmoc-Leu-OH Suppliers

Global Suppliers ( 698)
Supplier Tel Email Country ProdList Advantage
Lanxi Xingnuo Import and Export Trading Co., Ltd 0579-8831088 15888978871 994350525@qq.com China 23 58
GenChem & GenPharm (Changzhou) Co., Ltd. 0519-85720003 18861157602 410649415@qq.com China 111 58
Shandong fen Boyu Biotechnology Co.,LTD 13356310019 13356310019; boyu2024@163.com China 3947 58
Chengdu Tachem Co., Ltd 028-61682518; 19983060238 sales@tachem.cn China 102 58
Chengdu ZY Biochemical Technology Co., Ltd. 88680086 13398185735 fengzilong@zybiochem.com China 177 58
Wuhan Grand Hoyo Co., Ltd. 15377006636 670196467@qq.com China 31 58
Zhuhai Kerui Biotechnology Co., Ltd 18990613995 1342928505@qq.com China 133 58
Zhangjiagang Specom Biochemical Co., Ltd. 512-0512-58992291,58992287 18606280718 admin@spbiochem.com China 306 62
Emeishan Hongsen Biopharmaceutical Co., Ltd. 0833-6186278 19162541913 sales@hongshengpharm.com China 99 60
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
Lanxi Xingnuo Import and Export Trading Co., Ltd 58
GenChem & GenPharm (Changzhou) Co., Ltd. 58
Shandong fen Boyu Biotechnology Co.,LTD 58
Chengdu Tachem Co., Ltd 58
Chengdu ZY Biochemical Technology Co., Ltd. 58
Wuhan Grand Hoyo Co., Ltd. 58
Zhuhai Kerui Biotechnology Co., Ltd 58
Zhangjiagang Specom Biochemical Co., Ltd. 62
Emeishan Hongsen Biopharmaceutical Co., Ltd. 60
J & K SCIENTIFIC LTD. 76

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View Latest Price from Fmoc-Leu-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
FMOC-L-Leucine pictures 2026-09-17 FMOC-L-Leucine
35661-60-0
 1KG 98%min 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
Fmoc-L-leu-OH pictures 2026-09-17 Fmoc-L-leu-OH
35661-60-0
 1kg 98% 1T Sichuan HongRi Pharma-Tech Co.,Ltd
Fmoc-Leu-OH pictures 2026-08-19 Fmoc-Leu-OH
35661-60-0
 1KG 99% 1000 KG Shaanxi Dideu New Materials Co. Ltd
  • Fmoc-Leu-OH pictures
  • Fmoc-Leu-OH
    35661-60-0
  • $0.00
  • 99%
  • Shaanxi Dideu New Materials Co. Ltd

Fmoc-Leu-OH Spectrum

FMOC-L-Leucine(35661-60-0)MSFMOC-L-Leucine(35661-60-0)1HNMRFMOC-L-Leucine(35661-60-0)13CNMRFMOC-L-Leucine(35661-60-0)IR1FMOC-L-Leucine(35661-60-0)IR2

35661-60-0 (Fmoc-Leu-OH) Related Search:

Fmoc-Aib-OH 9-Fluorenylmethyl chloroformate FMOC-Ala-OH L-Leucine Fmoc-Asn(Trt)-OH
FMOC-O-tert-Butyl-L-serine Fmoc-Gly-OH Fmoc-L-Tyr(propargyl)-OH Fmoc-Lys(Boc)-OH Nalpha-Fmoc-Ndelta-trityl-L-glutamine
Fmoc-Tyr(tBu)-OH Fmoc-OSu L-tert-Leucine Glycine N-Carbobenzoxy-DL-leucine
Fmoc-tranexamic acid Fmoc-N-methyl-tranexamic acid Fmoc-MeTrp-OH

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FMOC-LEU-OH F-L-LEU Fmoc-L-leucine,98% L-Leucine-1-13C-N-FMOC Fmoc-N-(isobutyl)-glycine N-(fluorenyl-9-methoxycarbonyl)leucine FMOC-L-LEU-OH MONOHYDRATE Fmoc-N-(isobutyl)-Gly-OH FMOC-L-LEUCINE extrapure N-(9-Fluorenylmethoxycarbonyl)-L-leucine, Fmoc-L-leucine 2-(9H-fFuoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine ,98% (2S)-4-Methyl-2-(9H-fluorene-9-ylmethoxycarbonylamino)valeric acid (S)-2-[[(9H-Fluorene-9-yl)methoxycarbonyl]amino]-4-methylpentanoic acid N-[(9H-Fluorene-9-yl)methoxycarbonyl]leucine FMoc-L-leucine FMoc-Leu-OH 2-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO]-4-METHYLPENTANOIC ACID 9-FLUORENYLMETHOXYCARBONYL-L-LEUCINE Fmoc-Leucine-OH FMoc-Nleu-OH N-FMOC-LEU-OH N-FMOC-L-LEU NPC 15199 N-ALPHA-FMOC-L-LEUCINE N-(9-FLUORENYLMETHOXYCARBONYL)-L-LEUCINE N-9-FLUORENYLMETHYLOXYCARBONYL-L-LEUCINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-LEUCINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-LEUCINE PPAR-GAMMA ACTIVATOR N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-L-leucine, (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoic acid N-Fmoc-L-leucine Fmoc-Leu-OH FMoc-Leu-OH >=97.0% Fmoc-L-leucin (9H-Fluoren-9-yl)MethOxy]Carbonyl Leu-OH Fmoc-L-leucine≥ 99.7% (HPLC, Chiral purity) (2R)-2-amino-3-[4-[4-[(2R)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]phenyl]propanoic acid FMOC-LEU-OH 250 G FMOC-LEU-OH 100 G L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]- L-LEUCINE-N-FMOC (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoicaci Fmoc-Leu-OH Fmoc-Leu-OH FMOC-L-Leucine USP/EP/BP Fmoc-L-leucine, puriss, 99% N-(9-Fluorenylmethoxycarbonyl)-L-leucine Fmoc-L-leucine 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methylpentanoic acid N-Fmoc-L-leucine Fmoc-Leu-OH 98% (S)-2-(N-FMOC-Amino)-4-methylpentanoic acid (((9H-fluoren-9-yl)methoxy)carbonyl)-L-leucine (S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-4-Methylpentanoic acid FMOC-LEU FMOC-LEUCINE FMOC-L-LEUCINE FMOC-L-LEU-OH FMOC-L-LEU N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-LEUCINE N-FMOC-L-LEUCINE 35661-60-0 35661-60-6