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2-METHYLACETANILIDE

2-METHYLACETANILIDE structure

CAS No.: 120-66-1

Chemical Name:: 2-METHYLACETANILIDE

Synonyms: 2-Methylacetaniline;2'-methylacetanilide;Acet-o-toluidide;N-ACETYL-O-TOLUIDINE;O-ACETOTOLUIDE;O-TOLYLACETAMIDE;O-ACETOTOLUIDIDE;O-ACETOTOLUIDINE;2-ACETOTOLUIDINE;2-ACETAMIDOTOLUENE

CBNumber:: CB5746022

Molecular Formula:: C9H11NO

Molecular Weight:: 149.19

MDL Number:: MFCD00014961

MOL File:: 120-66-1.mol

MSDS File:: SDS

Last updated:2026-06-12 16:21:36

Product description	Number	Pack Size	Price
O-ACETOTOLUIDIDE Aldrich^CPR	S554383	1 unit	$197
O-ACETOTOLUIDIDE Aldrich	S554383	250mg	$179
o-Acetotoluidine >98.0%(GC)	A0063	25g	$38
N-Ac-2-methylaniline	FA34356	25g	$259.5
N-Ac-2-methylaniline	FA34356	50g	$389.5
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2-METHYLACETANILIDE Properties

Melting point	109-112 °C
Boiling point	296 °C
Density	1.16
refractive index	1.5279 (estimate)
Flash point	296°C
storage temp.	Sealed in dry,Room Temperature
solubility	It is slightly soluble in acetone, chloroform, toluene, benzene.
form	Solid
pka	15.13±0.70(Predicted)
color	Needles
Merck	14,74
BRN	2207054
InChI	InChI=1S/C9H11NO/c1-7-5-3-4-6-9(7)10-8(2)11/h3-6H,1-2H3,(H,10,11)
InChIKey	BPEXTIMJLDWDTL-UHFFFAOYSA-N
SMILES	C(NC1=CC=CC=C1C)(=O)C
CAS DataBase Reference	120-66-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	425I3L2A81
EPA Substance Registry System	o-Acetotoluidide (120-66-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38-22

Safety Statements

37/39-26-36-36/37

RTECS

AN2900000

Hazard Note

Harmful

TSCA

TSCA listed

HS Code

29242990

Hazardous Substances Data

120-66-1(Hazardous Substances Data)

Toxicity

mma-sat 1 mg/plate NTPTB* JAN 82

NFPA 704

	1
2		0

2-METHYLACETANILIDE price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S554383	O-ACETOTOLUIDIDE Aldrich^CPR	120-66-1	1 unit	$197	2026-04-30	Buy
Sigma-Aldrich	S554383	O-ACETOTOLUIDIDE Aldrich	120-66-1	250mg	$179	2024-03-01	Buy
TCI Chemical	A0063	o-Acetotoluidine >98.0%(GC)	120-66-1	25g	$38	2026-04-30	Buy
Biosynth	FA34356	N-Ac-2-methylaniline	120-66-1	25g	$259.5	2026-06-04	Buy
Biosynth	FA34356	N-Ac-2-methylaniline	120-66-1	50g	$389.5	2026-06-04	Buy

Product number	Packaging	Price	Buy
S554383	1 unit	$197	Buy
S554383	250mg	$179	Buy
A0063	25g	$38	Buy
FA34356	25g	$259.5	Buy
FA34356	50g	$389.5	Buy

2-METHYLACETANILIDE Chemical Properties,Uses,Production

Chemical Properties

WHITE TO OFF-WHITE CRYSTALLINE POWDER

Uses

o-Methylacetanilide is a substituted acetanilide that is used as precursor for various pharmaceuticals including their intermediates.

Uses

Acetanilide is used as an inhibitor of peroxides andstabilizer for cellulose ester varnishes.It is used as an intermediate for the synthesis ofrubber accelerators, dyes and dye intermediate and camphor. It is used as a precursor in penicillin synthesis and other pharmaceuticals including painkillers and intermediates.

Definition

ChEBI: 2`-Methylacetanilide is a member of toluenes.

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 5759, 1984 DOI: 10.1021/ja00331a073
Organic Syntheses, Coll. Vol. 5, p. 650, 1973

General Description

Colorless crystals. Insoluble in water.

Air & Water Reactions

Water insoluble.

Reactivity Profile

2-METHYLACETANILIDE is an amide. Amides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products.

Safety Profile

Moderately toxic by ingestion.Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the toluidide from hot H2O (solubility 1g/210mL), EtOH or aqueous EtOH. UV: max 230 and 280nm (EtOH). [Beilstein 12 H 792, 12 I 376, 12 II 439, 12 III 1853, 12 IV 1755.]

2-METHYLACETANILIDE Preparation Products And Raw materials

Raw materials

Acetic anhydride o-Toluidine Acetic acid

Preparation Products

2-Methyl-5-nitroaniline 2-Methyl-6-nitroaniline 4-Chloro-2-methylaniline 3-Acetamido-4-methylbenzoic acid 2-Bromo-3-nitrotoluene

2-CHLORO-N-(2-METHYLPHENYL)PROPANAMIDE 4'-Bromo-3'-methylacetophenone 2-CHLORO-3-NITROTOLUENE 4-IODO-2-METHYLANILINE 2-CHLOROQUINOLINE-3-CARBALDEHYDE

2-Methyl-5-nitrophenol 2,3-DINITROTOLUENE METHAQUALONE Sulphur Yellow 12 Acetamide, N-(2-methylphenyl)-, reaction products with [1,1'-biphenyl]-4,4'-diamine and sulfur, leuco derivs.

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2-METHYLACETANILIDE Suppliers

Global( 170)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14320	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34526	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
Changzhou Anxuan Chemical Co., Ltd	+86-0519-89882563 +86-18961279162	andy@anxuanchem.com	China	4326	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9628	58
sgtlifesciences pvt ltd	+91-8790379245	dj@sgtlifesciences.com	China	12351	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20000	58
Suzhou Victorypharm Co.,Ltd.	+86-13916956214	sales@victory-pharm.com	China	1298	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +8619957148339	market18@leapchem.com	China	24569	58

Supplier	Advantage
career henan chemical co	58
Standardpharm Co. Ltd.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Changzhou Anxuan Chemical Co., Ltd	58
changzhou huayang technology co., ltd	58
sgtlifesciences pvt ltd	58
Alfa Chemistry	58
Suzhou Victorypharm Co.,Ltd.	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from 2-METHYLACETANILIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-13	2-METHYLACETANILIDE 120-66-1		1KG	98%	2000	Shenzhen Nexcon Pharmatechs Ltd.
2026-06-30	2-METHYLACETANILIDE 120-66-1		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2019-07-06	2-METHYLACETANILIDE 120-66-1	$1.00	1kg	98%	100KG	Career Henan Chemical Co

2-METHYLACETANILIDE
120-66-1
98%
Shenzhen Nexcon Pharmatechs Ltd.

2-METHYLACETANILIDE
120-66-1
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

2-METHYLACETANILIDE
120-66-1
$1.00
98%
Career Henan Chemical Co

2-METHYLACETANILIDE Spectrum

2-METHYLACETANILIDE(120-66-1)MS 2-METHYLACETANILIDE(120-66-1)¹HNMR 2-METHYLACETANILIDE(120-66-1)¹³CNMR 2-METHYLACETANILIDE(120-66-1)IR1 2-METHYLACETANILIDE(120-66-1)IR2 2-METHYLACETANILIDE(120-66-1)Raman

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Acetamide,N-(2-methylphenyl)- N-Acetyl-o-toluidine 2'-Methylacetanilide Prilocaine Impurity 16 o-Acetotoluidine n-(2-methylphenyl)-acetamid N-(2-Methylphenyl)acetamide N-(2-Methyl-phenyl)acetamide O-TOLYLACETAMIDE O-METHYLACETANILIDE O-ACETOTOLUIDE O-ACETOTOLUIDIDE O-ACETOTOLUIDINE N-O-TOLYL-ACETAMIDE 2-ACETAMIDOTOLUENE 2-ACETOTOLUIDINE 2-METHYLACETANILIDE ACETYL-O-TOLUIDINE ACETO-O-AMINOTOLUENE N-acetyl-2-toluidine ACETYLORTHO-TOLUIDINE N-ACETYL-ORTHO-TOLUIDINE 2-Acetylaminotoluene N-(o-Methylphenyl)acetamide o-Acetotoluidide,99% N-(2-Methylphenyl)acetamide, 2-Acetamidotoluene 2-Methylacetanilide, 98+% N-Ac-2-methylaniline o-Acetotoluidine > 2-methylacylbenzeneamine 2-Methylacetaniline 2'-methylacetanilide Acet-o-toluidide N-ACETYL-O-TOLUIDINE 120-66-1 CH3CONHC6H4CH3 Anilines, Amides & Amines