7-Fluoroindole
- CAS No.
- 387-44-0
- Chemical Name:
- 7-Fluoroindole
- Synonyms
- 7-FLUORO-1H-INDOLE;uoro-1H-indoL;7-ETHOXYINDOLE;7-FLUOROINDOLE;7-Flouroindole;7-Fluoroindole>BUTTPARK 24\07-35;7-Fluoroindole,97%;7-Fluoroindole,98%;1H-Indole, 7-fluoro-
- CBNumber:
- CB4168733
- Molecular Formula:
- C8H6FN
- Molecular Weight:
- 135.14
- MDL Number:
- MFCD01074502
- MOL File:
- 387-44-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 7-Fluoro-1H-indole 97% | 740764 | 5g | $227 |
| 7-Fluoroindole >98.0%(GC) | F0555 | 1g | $135 |
| 7-Fluoroindole | F592268 | 2.5g | $140 |
| 7-Fluoroindole | F592268 | 5g | $250 |
| 7-Fluoroindole | J57204 | 25g | $293 |
| More product size | |||
| Melting point | 61 °C |
|---|---|
| Boiling point | 258.0±13.0 °C(Predicted) |
| Density | 1.273±0.06 g/cm3(Predicted) |
| Flash point | >110° |
| storage temp. | 2-8°C |
| solubility | Soluble in methanol. (almost transparency) |
| pka | 15.55±0.30(Predicted) |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| BRN | 114740 |
| InChI | InChI=1S/C8H6FN/c9-7-3-1-2-6-4-5-10-8(6)7/h1-5,10H |
| InChIKey | XONKJZDHGCMRRF-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2F)C=C1 |
| CAS DataBase Reference | 387-44-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-37/38-22 | |||||||||
| Safety Statements | 26-36-39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
7-Fluoroindole price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 740764 | 7-Fluoro-1H-indole 97% | 387-44-0 | 5g | $227 | 2026-03-19 | Buy |
| TCI Chemical | F0555 | 7-Fluoroindole >98.0%(GC) | 387-44-0 | 1g | $135 | 2026-03-19 | Buy |
| TRC | F592268 | 7-Fluoroindole | 387-44-0 | 2.5g | $140 | 2021-12-16 | Buy |
| TRC | F592268 | 7-Fluoroindole | 387-44-0 | 5g | $250 | 2021-12-16 | Buy |
| AK Scientific | J57204 | 7-Fluoroindole | 387-44-0 | 25g | $293 | 2021-12-16 | Buy |
7-Fluoroindole Chemical Properties,Uses,Production
Chemical Properties
Brown solid
Uses
7-Fluoroindole is a reagent used in chemical synthesis. It has been used to synthesize antiviral compounds against Pseudomonas aeruginosa and Staphylococcus aureus along with creation of immunomodulators. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
Antimicrobial activity
7-fluoroindole (7FI) was identified as a compound that inhibits biofilm formation and blood hemolysis without inhibiting the growth of planktonic P. aeruginosa cells. Moreover, 7FI markedly reduced the production of quorum-sensing (QS)-regulated virulence factors 2-heptyl-3-hydroxy-4(1H)-quinolone, pyocyanin, rhamnolipid, two siderophores, pyoverdine and pyochelin. 7FI clearly suppressed swarming motility, protease activity and the production of a polymeric matrix in P. aeruginosa. However, unlike natural indole compounds, synthetic 7FI did not increase antibiotic resistance. Therefore, 7FI is a potential candidate for use in an antivirulence approach against persistent P. aeruginosa infection.
Synthesis
317-20-4
387-44-0
Under nitrogen protection, 4 g (0.024 mol) of 7-fluoroindigo red and 3.52 g (0.093 mol) of sodium borohydride were placed in a dry four-necked flask and cooled below -10 °C. Under stirring conditions, 40 mL of anhydrous tetrahydrofuran and 7.6 g (0.054 mol) of boron trifluoride ether compounds were slowly added dropwise, keeping the temperature at no more than -5 °C throughout the dropwise addition. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, a solution prepared from 6.6 g of sodium bisulfate and 70 mL of water was slowly added dropwise to the reaction mixture. Subsequently, the mixture was steam distilled and the distillate was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and the solvent was removed by distillation to give 2.58 g of white acicular 7-fluoroindole in 78.8% yield.
References
[1] Patent: CN105732462, 2016, A. Location in patent: Paragraph 0016; 0019
7-Fluoroindole Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 4000 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| LAURENT | +8618100176782 | sun@laurentpeg.com | China | 365 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29822 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
View Lastest Price from 7-Fluoroindole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-29 | 7-Fluoroindole
387-44-0
|
US $0.00-0.00 / g | 1g | 98% | 300kg | LAURENT | |
 |
2025-12-24 | 7-Fluoroindole
387-44-0
|
US $0.10 / KG | 1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-09-25 | 7-Fluoroindole
387-44-0
|
US $36.00-1.50 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- 7-Fluoroindole
387-44-0
- US $0.00-0.00 / g
- 98%
- LAURENT
-
- 7-Fluoroindole
387-44-0
- US $0.10 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 7-Fluoroindole
387-44-0
- US $36.00-1.50 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
