3-Fluoro-4-methoxyacetophenone
- CAS No.
- 455-91-4
- Chemical Name:
- 3-Fluoro-4-methoxyacetophenone
- Synonyms
- Deracoxib 3-FMAP;BUTTPARK 153\33-60;Deracoxib Impurity 1;3-FLURO-4-METHOXYACETOPHENONE;3-FLUORO-4-METHOXYACETOPHENONE;3'-FLUORO-4-METHOXYACETOPHENONE;3'-Fluoro-4'-methoxyacetophenone;3’-Fluoro-4’-methyoxyacetophenone;3'-Fluoro-4'-methoxyacetophenone98%;3'-Fluoro-4'-methoxyacetophenone>
- CBNumber:
- CB6479734
- Molecular Formula:
- C9H9FO2
- Molecular Weight:
- 168.16
- MDL Number:
- MFCD00026219
- MOL File:
- 455-91-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 92-94 °C(lit.) |
|---|---|
| Boiling point | 147-148 °C20 mm Hg(lit.) |
| Density | 1.1410 (estimate) |
| Flash point | 147-148°C/20mm |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| color | White to Almost white |
| BRN | 2084062 |
| InChI | 1S/C9H9FO2/c1-6(11)7-3-4-9(12-2)8(10)5-7/h3-5H,1-2H3 |
| InChIKey | LQASUDVYVOFKNK-UHFFFAOYSA-N |
| SMILES | COc1ccc(cc1F)C(C)=O |
| CAS DataBase Reference | 455-91-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetophenone, 3'-fluoro-4'-methoxy-(455-91-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2914790090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
3-Fluoro-4-methoxyacetophenone price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 361836 | 3′-Fluoro-4′-methoxyacetophenone 99% | 455-91-4 | 5g | $64.8 | 2026-04-30 | Buy |
| TCI Chemical | F0366 | 3'-Fluoro-4'-methoxyacetophenone >98.0%(GC) | 455-91-4 | 5g | $40 | 2026-04-30 | Buy |
| TCI Chemical | F0366 | 3'-Fluoro-4'-methoxyacetophenone >98.0%(GC) | 455-91-4 | 25g | $115 | 2026-04-30 | Buy |
| Strem Chemicals | 09-0080 | 3'-Fluoro-4'- methoxyacetophenone, min. 98% min.98% | 455-91-4 | 25g | $50 | 2026-04-30 | Buy |
| Strem Chemicals | 09-0080 | 3'-Fluoro-4'- methoxyacetophenone, min. 98% min.98% | 455-91-4 | 100g | $104 | 2026-04-30 | Buy |
3-Fluoro-4-methoxyacetophenone Chemical Properties,Uses,Production
Uses
3’-Fluoro-4’methoxyacetophenone is used in the synthesis chalcones,
Preparation
Obtained by fluorination of 4-methoxyacetophenone with manganese (IV) tetrafluoride formed in situ using manganese (IV) dioxide and pyridinium polyhydrogenofluoride under very mild conditions.
General Description
3′-Fluoro-4′-methoxyacetophenone can be prepared by Friedel-Crafts reaction of o-fluoroanisole with acetic anhydride.
Synthesis
321-28-8
75-36-5
455-91-4
Under ice bath conditions, 6.38 g (48 mmol) of aluminum trichloride and 40 mL of methylene chloride were added to a 100 mL round bottom flask and stirred until dissolved. Subsequently, 4.68 g (60 mmol) of acetyl chloride was slowly added, keeping the reaction temperature at 5 to 10 °C. Stirring was continued at 5°C for 10 minutes, followed by the slow dropwise addition of 5.04 g (40 mmol) 2-fluoroanisole. After the dropwise addition was completed, the reaction mixture was stirred at 5°C for 1 hour. Upon completion of the reaction, the mixture was carefully poured into 100 mL of ice water to quench the reaction. The aqueous layer was extracted with dichloromethane (2 x 30 mL) and the organic phases were combined. The organic phase was washed sequentially with water (2 x 30 mL), dried over anhydrous magnesium sulfate, filtered and concentrated. The crude product was washed with petroleum ether and finally recrystallized with ethyl acetate to obtain the target product 3-fluoro-4-methoxyacetophenone in 92.4% yield.
References
[1] Patent: CN107686465, 2018, A. Location in patent: Paragraph 0041; 0053; 0054
[2] Patent: US6342510, 2002, B1. Location in patent: Page column 28
[3] Patent: US5098602, 1992, A
[4] Patent: WO2006/136829, 2006, A2. Location in patent: Page/Page column 123
[5] Journal of Organic Chemistry, 1953, vol. 18, p. 910,914
3-Fluoro-4-methoxyacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Lastest Price from 3-Fluoro-4-methoxyacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-21 | 3-Fluoro-4-methoxyacetophenone
455-91-4
|
$1.00-6.00 | 1g | 99% | 300tons | Hebei Dangtong Import and export Co LTD | |
 |
2026-05-28 | 3-Fluoro-4-methoxyacetophenone
455-91-4
|
$9.00 | 1KG | 99.8% | 100tons | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2025-06-27 | 3-Fluoro-4-methoxyacetophenone
455-91-4
|
$10.00-30.00 | 50KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 3-Fluoro-4-methoxyacetophenone
455-91-4
- $1.00-6.00
- 99%
- Hebei Dangtong Import and export Co LTD
-
- 3-Fluoro-4-methoxyacetophenone
455-91-4
- $9.00
- 99.8%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 3-Fluoro-4-methoxyacetophenone
455-91-4
- $10.00-30.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
