2-Amino-3-nitro-4-picoline
- CAS No.
- 6635-86-5
- Chemical Name:
- 2-Amino-3-nitro-4-picoline
- Synonyms
- 2-AMINO-4-METHYL-3-NITROPYRIDINE;NSC 52453;TIMTEC-BB SBB006636;4-METHYL-3-NITRO-PYRI;2-AMINO-3-NITRO-4-PICOLINE;2-AMino-4-Methyl-3-nitrop...;2-Amino-3-nitro-4-picoline,98%;4-Methyl-3-nitro-2-pyridinamine;2-amin-3-nitro-4-methylpyridine;3-Nitro-4-methyl-2-pyridinamine
- CBNumber:
- CB6671998
- Molecular Formula:
- C6H7N3O2
- Molecular Weight:
- 153.14
- MDL Number:
- MFCD00006315
- MOL File:
- 6635-86-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 136-140 °C(lit.) |
|---|---|
| Boiling point | 276.04°C (rough estimate) |
| Density | 1.3682 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | Crystalline Powder |
| pka | 2.97±0.47(Predicted) |
| color | Yellow |
| BRN | 139111 |
| InChI | InChI=1S/C6H7N3O2/c1-4-2-3-8-6(7)5(4)9(10)11/h2-3H,1H3,(H2,7,8) |
| InChIKey | IKMZGACFMXZAAT-UHFFFAOYSA-N |
| SMILES | C1(N)=NC=CC(C)=C1[N+]([O-])=O |
| CAS DataBase Reference | 6635-86-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyridine, 2-amino-3-nitro-4-methyl-(6635-86-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Amino-3-nitro-4-picoline price More Price(77)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 290084 | 2-Amino-4-methyl-3-nitropyridine 98% | 6635-86-5 | 25g | $300 | 2023-06-20 | Buy |
| Sigma-Aldrich | 290084 | 2-Amino-4-methyl-3-nitropyridine 98% | 6635-86-5 | 5g | $152 | 2023-01-07 | Buy |
| TCI Chemical | A1888 | 2-Amino-4-methyl-3-nitropyridine >98.0%(GC)(T) | 6635-86-5 | 1g | $22 | 2026-04-30 | Buy |
| TCI Chemical | A1888 | 2-Amino-4-methyl-3-nitropyridine >98.0%(GC)(T) | 6635-86-5 | 5g | $53 | 2026-04-30 | Buy |
| Usbiological | 229782 | 2-Amino-4-methyl-3-nitropyridine 98+% ≥98% | 1g | $156 | 2026-06-03 | Buy |
2-Amino-3-nitro-4-picoline Chemical Properties, Uses, Production
Chemical Properties
light yellow crystal powder
Uses
2-Amino-4-methyl-3-nitropyridine was used in the synthesis of 2-amino-5-hydroxy-4-methyl-3-nitropyridine, 2-amino-4-hydroxymethyl-3-nitropyridine and 2-amino-4-methyl-3-nitropyridine-1-oxide by undergoing biotransformation by Cunninghamella elegans ATCC 26269.
General Description
The crystal structure of 2-amino-4-methyl-3-nitropyridine was elucidated.
Synthesis
695-34-1
21901-40-6
6635-86-5
The general procedure for the synthesis of 2-amino-4-methyl-5-nitropyridine and 4-methyl-3-nitropyridin-2-amine from 2-amino-4-methylpyridine was carried out as follows: commercially available 2-amino-4-methylpyridine (Fluka, purity >99%) was used as starting material according to the method previously described by Talik and Talik [29]. This was done as follows: 25 g of 2-amino-4-methylpyridine was dissolved in 125 cm3 concentrated sulfuric acid (Fluka, 96%). The reaction mixture was cooled to 0°C under strong stirring by adding ice mixed with sodium chloride. Subsequently, 37.5 cm3 of nitric acid (Chempur, 65%, density = 1.4 g/cm3) was slowly added, keeping the reaction temperature below 10°C. The reaction mixture was stirred under continuous cooling for 1.5 hours, followed by standing at room temperature for 1 hour. Next, the reaction mixture was sequentially heated in a water bath at 40°C for half an hour, at 60-70°C for 1 hour and in a boiling water bath for half an hour. After completion of the reaction, the mixture was cooled to room temperature, poured into ice water and adjusted to a weakly basic pH with ammonia. the solid product was collected by vacuum filtration. Steam distillation was utilized to separate the two nitro isomers (3-nitro and 5-nitro isomers). The more volatile 3-nitro isomer (I) was first distilled and concentrated and dried to give the pure product (10 g). The residual 5-nitro isomer (III) was collected by filtration and recrystallized from water (initial addition of sulfuric acid and activated carbon to dissolve the compound and remove impurities). After neutralization, filtration and drying, about 15 g of 5-nitroisomer (III) was obtained. 2-Amino-4-methyl-3,5-dinitropyridine (II) was prepared from 2-amino-4-methyl-5-nitropyridine (III) using a similar method (nitration and rearrangement to dinitropyridine). The residue was purified by crystallization in water to give 2-amino-4-methyl-3-nitropyridine (I) (yield: 27%, 10 g, melting point 134 °C), 2-amino-4-methyl-3,5-dinitropyridine (II) (yield: 80%, 10.4 g, melting point 197 °C) and 2-amino-4-methyl-5-nitropyridine (III) (yield: 40%, 15 g (yield: 40%, 15g, melting point 218°C). Melting points were determined using a Kfler apparatus and the chemical composition of the compounds was verified by Carlo Erba Analyzer (model 1104).
References
[1] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2012, vol. 96, p. 952 - 962
[2] Journal of the Chemical Society, 1954, p. 2448,2455
[3] Journal of the American Chemical Society, 1955, vol. 77, p. 3154
[4] Journal of Fluorine Chemistry, 2011, vol. 132, # 8, p. 541 - 547
[5] Journal of Molecular Structure, 2013, vol. 1043, p. 15 - 27
2-Amino-3-nitro-4-picoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 2-Amino-3-nitro-4-picoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-02 | 2-Amino-3-nitro-4-picoline
6635-86-5
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 2-Amino-3-nitro-4-picoline
6635-86-5
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-06-30 | 2-Amino-3-nitro-4-picoline
6635-86-5
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2-Amino-3-nitro-4-picoline
6635-86-5
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2-Amino-3-nitro-4-picoline
6635-86-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Amino-3-nitro-4-picoline
6635-86-5
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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