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2-Amino-3-nitro-4-picoline

2-Amino-3-nitro-4-picoline Structure
2-Amino-3-nitro-4-picoline structure
CAS No.
6635-86-5
Chemical Name:
2-Amino-3-nitro-4-picoline
Synonyms
NSC 52453;TIMTEC-BB SBB006636;4-METHYL-3-NITRO-PYRI;2-AMINO-3-NITRO-4-PICOLINE;2-AMino-4-Methyl-3-nitrop...;2-Amino-3-nitro-4-picoline,98%;4-Methyl-3-nitro-2-pyridinamine;2-amin-3-nitro-4-methylpyridine;3-Nitro-4-methyl-2-pyridinamine;4-methyl-3-nitropyridin-2-amine
CBNumber:
CB6671998
Molecular Formula:
C6H7N3O2
Molecular Weight:
153.14
MDL Number:
MFCD00006315
MOL File:
6635-86-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-20 15:45:17
Product description Number Pack Size Price
2-Amino-4-methyl-3-nitropyridine 98% 290084 25g $300
2-Amino-4-methyl-3-nitropyridine 98% 290084 5g $152
2-Amino-4-methyl-3-nitropyridine >98.0%(GC)(T) A1888 1g $22
2-Amino-4-methyl-3-nitropyridine >98.0%(GC)(T) A1888 5g $53
2-Amino-4-methyl-3-nitropyridine ≥98%(Assay) 27029 5G $22.03
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2-Amino-3-nitro-4-picoline Properties

Melting point 136-140 °C(lit.)
Boiling point 276.04°C (rough estimate)
Density 1.3682 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 2.97±0.47(Predicted)
form Crystalline Powder
color Yellow
BRN 139111
InChI InChI=1S/C6H7N3O2/c1-4-2-3-8-6(7)5(4)9(10)11/h2-3H,1H3,(H2,7,8)
InChIKey IKMZGACFMXZAAT-UHFFFAOYSA-N
SMILES C1(N)=NC=CC(C)=C1[N+]([O-])=O
CAS DataBase Reference 6635-86-5(CAS DataBase Reference)
NIST Chemistry Reference Pyridine, 2-amino-3-nitro-4-methyl-(6635-86-5)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36-36/37/39-22
WGK Germany  3
F  10
HazardClass  IRRITANT
HS Code  29333999
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Amino-3-nitro-4-picoline price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 290084 2-Amino-4-methyl-3-nitropyridine 98% 6635-86-5 25g $300 2023-06-20 Buy
Sigma-Aldrich 290084 2-Amino-4-methyl-3-nitropyridine 98% 6635-86-5 5g $152 2023-01-07 Buy
TCI Chemical A1888 2-Amino-4-methyl-3-nitropyridine >98.0%(GC)(T) 6635-86-5 1g $22 2026-04-30 Buy
TCI Chemical A1888 2-Amino-4-methyl-3-nitropyridine >98.0%(GC)(T) 6635-86-5 5g $53 2026-04-30 Buy
Chem-Impex 27029 2-Amino-4-methyl-3-nitropyridine ≥98%(Assay) 6635-86-5 5G $22.03 2026-05-19 Buy
Product number Packaging Price Buy
290084 25g $300 Buy
290084 5g $152 Buy
A1888 1g $22 Buy
A1888 5g $53 Buy
27029 5G $22.03 Buy

2-Amino-3-nitro-4-picoline Chemical Properties,Uses,Production

Chemical Properties

light yellow crystal powder

Uses

2-Amino-4-methyl-3-nitropyridine was used in the synthesis of 2-amino-5-hydroxy-4-methyl-3-nitropyridine, 2-amino-4-hydroxymethyl-3-nitropyridine and 2-amino-4-methyl-3-nitropyridine-1-oxide by undergoing biotransformation by Cunninghamella elegans ATCC 26269.

General Description

The crystal structure of 2-amino-4-methyl-3-nitropyridine was elucidated.

Synthesis

4-Methylpyridin-2-amine

695-34-1

2-Amino-5-nitro-4-picoline

21901-40-6

2-Amino-3-nitro-4-picoline

6635-86-5

The general procedure for the synthesis of 2-amino-4-methyl-5-nitropyridine and 4-methyl-3-nitropyridin-2-amine from 2-amino-4-methylpyridine was carried out as follows: commercially available 2-amino-4-methylpyridine (Fluka, purity >99%) was used as starting material according to the method previously described by Talik and Talik [29]. This was done as follows: 25 g of 2-amino-4-methylpyridine was dissolved in 125 cm3 concentrated sulfuric acid (Fluka, 96%). The reaction mixture was cooled to 0°C under strong stirring by adding ice mixed with sodium chloride. Subsequently, 37.5 cm3 of nitric acid (Chempur, 65%, density = 1.4 g/cm3) was slowly added, keeping the reaction temperature below 10°C. The reaction mixture was stirred under continuous cooling for 1.5 hours, followed by standing at room temperature for 1 hour. Next, the reaction mixture was sequentially heated in a water bath at 40°C for half an hour, at 60-70°C for 1 hour and in a boiling water bath for half an hour. After completion of the reaction, the mixture was cooled to room temperature, poured into ice water and adjusted to a weakly basic pH with ammonia. the solid product was collected by vacuum filtration. Steam distillation was utilized to separate the two nitro isomers (3-nitro and 5-nitro isomers). The more volatile 3-nitro isomer (I) was first distilled and concentrated and dried to give the pure product (10 g). The residual 5-nitro isomer (III) was collected by filtration and recrystallized from water (initial addition of sulfuric acid and activated carbon to dissolve the compound and remove impurities). After neutralization, filtration and drying, about 15 g of 5-nitroisomer (III) was obtained. 2-Amino-4-methyl-3,5-dinitropyridine (II) was prepared from 2-amino-4-methyl-5-nitropyridine (III) using a similar method (nitration and rearrangement to dinitropyridine). The residue was purified by crystallization in water to give 2-amino-4-methyl-3-nitropyridine (I) (yield: 27%, 10 g, melting point 134 °C), 2-amino-4-methyl-3,5-dinitropyridine (II) (yield: 80%, 10.4 g, melting point 197 °C) and 2-amino-4-methyl-5-nitropyridine (III) (yield: 40%, 15 g (yield: 40%, 15g, melting point 218°C). Melting points were determined using a Kfler apparatus and the chemical composition of the compounds was verified by Carlo Erba Analyzer (model 1104).

References

[1] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2012, vol. 96, p. 952 - 962
[2] Journal of the Chemical Society, 1954, p. 2448,2455
[3] Journal of the American Chemical Society, 1955, vol. 77, p. 3154
[4] Journal of Fluorine Chemistry, 2011, vol. 132, # 8, p. 541 - 547
[5] Journal of Molecular Structure, 2013, vol. 1043, p. 15 - 27

2-Amino-3-nitro-4-picoline Preparation Products And Raw materials

Raw materials

4-Methylpyridin-2-amine

Preparation Products

N-(2-Amino-4-methylpyridin-3-yl)-2-chloropyridine-3-carboxamide 3-Fluoropyridine-4-carboxylic acid 2-Chloro-4-methyl-3-nitropyridine Ethyl 7-methyl-8-nitroimidazo-[1,2-a]pyridine-2-carboxylate 4-Methyl-3-nitro-pyridine-2-carbonitrile
4-Methyl-2-(1H-pyrrol-1-yl)pyridin-3-amine 2H-Pyrazolo[3,4-c]pyridin-7-aMine

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2-Amino-3-nitro-4-picoline Suppliers

Global( 370)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 880 50
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29640 60
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29816 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Capot Chemical Co.,Ltd. 		60
Hi-Tech Chemistry Corp 		58
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58

View Lastest Price from 2-Amino-3-nitro-4-picoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-3-nitro-4-picoline pictures 2025-12-01 2-Amino-3-nitro-4-picoline
6635-86-5
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Amino-3-nitro-4-picoline pictures 2025-11-18 2-Amino-3-nitro-4-picoline
6635-86-5
 US $1.10 / g 1g 99.00% 100 Tons min Dideu Industries Group Limited
2-Amino-3-nitro-4-picoline pictures 2025-09-25 2-Amino-3-nitro-4-picoline
6635-86-5
 US $5.00-0.10 / KG 1KG 98% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

2-Amino-3-nitro-4-picoline Spectrum

2-Amino-3-nitro-4-picoline(6635-86-5)MS2-Amino-3-nitro-4-picoline(6635-86-5)1HNMR2-Amino-3-nitro-4-picoline(6635-86-5)13CNMR2-Amino-3-nitro-4-picoline(6635-86-5)IR12-Amino-3-nitro-4-picoline(6635-86-5)IR22-Amino-3-nitro-4-picoline(6635-86-5)Raman

6635-86-5(2-Amino-3-nitro-4-picoline)Related Search:

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4-Methyl-3-nitro-2-pyridinamine 2-Amino-4-methyl-3-nitropyridine,97% 4-METHYL-3-NITRO-PYRI TIMTEC-BB SBB006636 2-AMINO-4-METHYL-3-NITROPYRIDINE 2-AMINO-3-NITRO-4-METHYLPYRIDINE 2-AMINO-3-NITRO-4-PICOLINE 4-METHYL-3-NITRO-PYRIDIN-2-YLAMINE 2-amin-3-nitro-4-methylpyridine 2-Amino-3-nitro-4-methoxypyridine 2-Amino-4-methy -5-nitropyridine 2-Amino-4-Mythyl-3-NitroPyridine 2-AMINO-3-NITRO-4-METHOXYPYRIDIN 2-PYRIDINAMINE, 4-METHYL-3-NITRO- 2-AMINO-3-NITRO-4-PICOLINE (2-AMINO-4-METHYL-3-NITROPYRIDINE) 3-Nitro-4-methyl-2-pyridinamine 3-Nitro-4-methylpyridine-2-amine 2-Amino-3-nitro-4-picoline,98% 4-methyl-3-nitropyridin-2-amine 2-AMino-4-Methyl-3-nitrop... NSC 52453 2-Amino-4-methyl-3-nitropyridine 98% 2-Amino-4-methyl-3-nitropyridine > 6-methyl-3-nitropyridin-3-amine 2-Amino-3-nitro-4-picoline ISO 9001：2015 REACH 6635-86-5 6645-86-5 6635-85-6 AMINO Pyridines Heterocyclic Building Blocks Building Blocks C6 Pyridines Boronic Acid Heterocycle-Pyridine series amine |nitro-compound Pyridine Pyridine series Amines Aromatics Heterocycles