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2-Amino-4-fluorophenol

2-Amino-4-fluorophenol Structure
2-Amino-4-fluorophenol structure
CAS No.
399-97-3
Chemical Name:
2-Amino-4-fluorophenol
Synonyms
Aminofluorophenol1;2-AMINO-4-FLUOROPHEN;2-Amino-4-fluorophenol;5-Fluoro-2-hydroxyaniline;Phenol, 2-amino-4-fluoro-;2-Amino-4-fluorophenol98%;2-Amino-4-fluorophenol >2-Amino-4-fluorophenol 98%;2- aMino-4-difluoro phenol;6007 2-AMINO-4-FLUORO PHENOL
CBNumber:
CB7113996
Molecular Formula:
C6H6FNO
Molecular Weight:
127.12
MDL Number:
MFCD00077451
MOL File:
399-97-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:54:27
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2-Amino-4-fluorophenol Properties

Melting point 130-135 °C
Boiling point 252.9±25.0 °C(Predicted)
Density 1.347±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility soluble in Methanol
form powder to crystal
pka 9.77±0.18(Predicted)
color Light yellow to Brown
InChI InChI=1S/C6H6FNO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H,8H2
InChIKey ULDFRPKVIZMKJG-UHFFFAOYSA-N
SMILES C1(O)=CC=C(F)C=C1N
CAS DataBase Reference 399-97-3(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38-22
Safety Statements  26-36/37/39
WGK Germany  3
HazardClass  IRRITANT
HS Code  29222990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

2-Amino-4-fluorophenol price More Price(64)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 683302 2-Amino-4-fluorophenol 96% 399-97-3 1g $75.8 2026-04-30 Buy
TCI Chemical A2400 2-Amino-4-fluorophenol >97.0%(T) 399-97-3 5g $409 2026-04-30 Buy
TCI Chemical A2400 2-Amino-4-fluorophenol >97.0%(T) 399-97-3 25g $1757 2026-04-30 Buy
Usbiological 261090 2-Amino-4-fluorophenol Asreported 399-97-3 10g $379 2026-06-03 Buy
Usbiological 261090 2-Amino-4-fluorophenol Asreported 399-97-3 25g $582 2026-06-03 Buy
Product number Packaging Price Buy
683302 1g $75.8 Buy
A2400 5g $409 Buy
A2400 25g $1757 Buy
261090 10g $379 Buy
261090 25g $582 Buy

2-Amino-4-fluorophenol Chemical Properties, Uses, Production

Application

2-Amino-4-fluorophenol has wide applications in drug synthesis, serving as a synthetic intermediate for certain drugs. Furthermore, it possesses antibacterial and anti-inflammatory properties, making it useful in treating some infectious and inflammatory diseases.

Chemical Properties

White to brown solid

Synthesis

2-Nitro-4-fluorophenol

394-33-2

2-AMINO-4-FLUOROPHENOL

399-97-3

The general procedure for the synthesis of 2-amino-4-fluorophenol from 2-nitro-4-fluorophenol was as follows: tin(II) chloride (12.1 g, 63.6 mmol) was added to a solution of 4-fluoro-2-nitrophenol (2.00 g, 12.7 mmol) in ethanol (45 mL). The reaction mixture was heated to 70 °C and maintained at this temperature for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into ice water (~200 mL). After the mixture was warmed to room temperature, the pH was adjusted with 2N NaOH aqueous solution to about 9. The reaction mixture was filtered and the filtrate was extracted with ethyl acetate (3×). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and the organic phase was concentrated under reduced pressure. 1.21 g (75% yield) of 2-amino-4-fluorophenol was finally obtained.Results of LC-MS analysis: retention time (RT) = 4.48 min, [M + H]+ = 128.0.

References

[1] Patent: EP1346982, 2003, A1
[2] Inorganic Chemistry, 2010, vol. 49, # 23, p. 11106 - 11117
[3] Patent: WO2007/146066, 2007, A2. Location in patent: Page/Page column 80
[4] Journal of Organic Chemistry, 1951, vol. 16, p. 1345,1348
[5] J. Gen. Chem. USSR (Engl. Transl.), 1975, vol. 45, p. 2372 - 2379

2-Amino-4-fluorophenol Preparation Products And Raw materials

Raw materials

2-Nitro-4-fluorophenol Propyl acetate Sodium hydroxide

Preparation Products

5-Fluoro-2-methyl-quinolin-8-ol 5-Fluoro-1,3-benzoxazol-2(3H)-one

2-Amino-4-fluorophenol Suppliers

Global Suppliers ( 264)
Supplier Tel Email Country ProdList Advantage
Jinan Guangchen Pharmaceutical Technology Co., Ltd 18563726319 2845578351@qq.com China 7026 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Jinan Guangchen Pharmaceutical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Ark Pharm, Inc. 56
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

View Latest Price from 2-Amino-4-fluorophenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-4-fluorophenol pictures 2025-02-13 2-Amino-4-fluorophenol
399-97-3
 $1.00 1g 99% 10000 Apeloa production Co.,Limited
2-Amino-4-fluorophenol pictures 2022-02-22 2-Amino-4-fluorophenol
399-97-3
 1KG 97.4% 100 tons Honest Joy Holdings Limited
2-AMINO-4-FLUOROPHENOL pictures 2020-01-13 2-AMINO-4-FLUOROPHENOL
399-97-3
 $1.00 1g 99.0% 100kg Career Henan Chemical Co

2-Amino-4-fluorophenol Spectrum

2-AMINO-4-FLUOROPHENOL(399-97-3)1HNMR

399-97-3 (2-Amino-4-fluorophenol) Related Search:

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Aminofluorophenol1 2-Amino-4-fluorophenol 98% 2-Amino-4-fluorophenol98% 2-Amino-4-fluorophenol, 98% (H26165) 2-AMINO-4-FLUOROPHEN 6007 2-AMINO-4-FLUORO PHENOL 5-Fluoro-2-hydroxyaniline 2- aMino-4-difluoro phenol Phenol, 2-amino-4-fluoro- 2-Amino-4-fluorophenol > 2-AMINO-4-FLUOROPHENOL ISO 9001：2015 REACH 2-Amino-4-fluorophenol 399-97-3 Fluorine series Aromatic Phenols Phenol&Thiophenol&Mercaptan