5-Phenylthiophene-2-carboxylic acid
- CAS No.
- 19163-24-7
- Chemical Name:
- 5-Phenylthiophene-2-carboxylic acid
- Synonyms
- AKOS B029964;AKOS BAR-0576;BUTTPARK 98\04-16;RARECHEM AL BE 0489;5-Phenyl-2-thenoic Acid;2-Carboxy-5-phenylthiophene;5-phenyl-2-furancarbothioic S-acid;5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID;5-PHENYL-2-THIOPHENECARBOXYLIC ACID;2-Thiophenecarboxylic acid, 5-phenyl-
- CBNumber:
- CB7123393
- Molecular Formula:
- C11H8O2S
- Molecular Weight:
- 204.25
- MDL Number:
- MFCD01313432
- MOL File:
- 19163-24-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 186-190°C |
|---|---|
| Boiling point | 393.6±30.0 °C(Predicted) |
| Density | 1.303±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| form | powder to crystal |
| pka | 3.52±0.10(Predicted) |
| color | White to Orange to Green |
| λmax | 310nm(EtOH)(lit.) |
| CAS DataBase Reference | 19163-24-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
5-Phenylthiophene-2-carboxylic acid price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L498998 | 5-PHENYL-2-THIOPHENECARBOXYLIC ACID AldrichCPR | 19163-24-7 | 1 unit | $45.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | L498998 | 5-PHENYL-2-THIOPHENECARBOXYLIC ACID AldrichCPR | 19163-24-7 | 250MG | $41.5 | 2024-03-01 | Buy |
| TCI Chemical | P2347 | 5-Phenyl-2-thiophenecarboxylic Acid >98.0%(GC)(T) | 19163-24-7 | 250mg | $51 | 2026-04-30 | Buy |
| TCI Chemical | P2347 | 5-Phenyl-2-thiophenecarboxylic Acid >98.0%(GC)(T) | 19163-24-7 | 1g | $149 | 2025-07-31 | Buy |
| Usbiological | 288329 | 5-Phenylthiophene-2-carboxylic acid Asreported | 19163-24-7 | 500mg | $382 | 2026-06-03 | Buy |
5-Phenylthiophene-2-carboxylic acid Chemical Properties,Uses,Production
Uses
Thiophene derivatives are widely used in the synthesis of pesticides, pharmaceuticals, chemical reagents, dyes, and polymer auxiliaries. 5-Phenylen-2-carboxylic acid has extensive applications in organic synthesis.
Definition
ChEBI: 5-Phenylthiophene-2-carboxylic acid is a thiophenecarboxylic acid.
Synthesis
14597-62-7
19163-24-7
GENERAL STEPS: To a mixed solution of methanol (5 mL) and tetrahydrofuran (5 mL) of 2-methoxycarbonyl-5-phenylthiophene (437 mg) was added 1 N aqueous sodium hydroxide (3 mL), and the reaction was stirred for 2 hours at room temperature. After completion of the reaction, 1 N hydrochloric acid (5 mL) was slowly added to the reaction mixture for acidification. The precipitated solid was collected by filtration and washed with a small amount of cold water and dried under vacuum to give 5-phenylthiophene-2-carboxylic acid (397 mg, 97.1% yield). The product was confirmed by NMR hydrogen spectrum (DMSO-d6, δ): 7.3-7.5 (3H, m), 7.58 (1H, d, J = 3.9 Hz), 7.6-7.8 (3H, m), 13.15 (1H, wide s). Electrospray mass spectrometry (ESI-MS) showed m/z: 203 ([M-H]-).
References
[1] Patent: US6770667, 2004, B1. Location in patent: Page column 11
[2] ChemMedChem, 2011, vol. 6, # 2, p. 362 - 377
[3] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 96 - 107
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5536 - 5548
5-Phenylthiophene-2-carboxylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 |
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