4,6-Dichloro-pyridin-3-ylamine
- CAS No.
- 7321-93-9
- Chemical Name:
- 4,6-Dichloro-pyridin-3-ylamine
- Synonyms
- 4,6-DICHLOROPYRIDIN-3-AMINE;4,6-Dichloro-3-pyridinamine;5-AMINO-2,4-DICHLOROPYRIDINE;2,4-Dichloro-5-aMinopyridine;3-Pyridinamine, 4,6-dichloro-;4,6-Dichloro-pyridin-3-ylamine;5-Amino-2,4-dichloropyridine 97+%;Pyridine,5-amino-2,4-dichloro- (7CI,8CI);4,6-DICHLORO-PYRIDIN-3-YLAMINE ISO 9001：2015 REACH
- CBNumber:
- CB7222007
- Molecular Formula:
- C5H4Cl2N2
- Molecular Weight:
- 163
- MDL Number:
- MFCD00234054
- MOL File:
- 7321-93-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 80-81 °C(Solv: ligroine (8032-32-4)) |
|---|---|
| Boiling point | 290.8±35.0 °C(Predicted) |
| Density | 1.497±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | Powder |
| pka | 0.72±0.10(Predicted) |
| color | Pale brown |
| InChI | InChI=1S/C5H4Cl2N2/c6-3-1-5(7)9-2-4(3)8/h1-2H,8H2 |
| InChIKey | FBGVTWONYOCYGA-UHFFFAOYSA-N |
| SMILES | C1=NC(Cl)=CC(Cl)=C1N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| RIDADR | UN2811 | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
4,6-Dichloro-pyridin-3-ylamine price More Price(85)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 273989 | 4,6-Dichloro-pyridin-3-ylamine Asreported | 7321-93-9 | 50mg | $366 | 2026-06-03 | Buy |
| Usbiological | 273989 | 4,6-Dichloro-pyridin-3-ylamine Asreported | 7321-93-9 | 100mg | $508 | 2026-06-03 | Buy |
| Usbiological | 273989 | 4,6-Dichloro-pyridin-3-ylamine Asreported | 7321-93-9 | 250mg | $641 | 2026-06-03 | Buy |
| Usbiological | 273989 | 4,6-Dichloro-pyridin-3-ylamine Asreported | 7321-93-9 | 500mg | $864 | 2026-06-03 | Buy |
| Usbiological | 273989 | 4,6-Dichloro-pyridin-3-ylamine Asreported | 7321-93-9 | 1g | $1243 | 2026-06-03 | Buy |
4,6-Dichloro-pyridin-3-ylamine Chemical Properties, Uses, Production
Uses
4,6-Dichloropyridin-3-amine is an organic amine compound used in the synthesis of 2,4,5-Trichloropyridine and its derivatives. It is also used as a pharmaceutical intermediate component in the preparation of aromatic bridging cyclic amide derivatives for hepatitis B virus infection.
Synthesis
70593-57-6
7321-93-9
The general procedure for the synthesis of 2,4-dichloro-5-aminopyridine from 4,6-dichloropyridin-3-amide was as follows: sodium hydroxide (6.60 g, 165 mmol) was dissolved in water (31 mL) and cooled in an ice bath. Subsequently, bromine (2.08 mL, 40.6 mmol) was added dropwise and the resulting yellow solution was stirred for 15 minutes. A 1,4-dioxane (21 mL) solution of 4,6-dichloronicotinamide (7.27 g, 38.1 mmol) was slowly added dropwise to the above bromine solution over 30 minutes. The reaction mixture was allowed to gradually warm up to 25°C over 18 hours. Upon completion of the reaction, the volatiles were removed by distillation under reduced pressure and the remaining solution was diluted with brine and poured into ethyl acetate. The aqueous phase was separated and extracted twice with ethyl acetate. The organic layers were combined, dried with sodium sulfate, decanted and concentrated to give an orange colored oil. The oily substance was purified by passing through a 100 g silica gel fast column using 25% ethyl acetate-hexane as eluent to give 4,6-dichloropyridin-3-ylamine as a brown solid (4.54 g, 73% yield). Finally, 30% aqueous hydrogen peroxide solution (29 mL) was cooled in an ice bath.
References
[1] Patent: US2006/217417, 2006, A1. Location in patent: Page/Page column 13
4,6-Dichloro-pyridin-3-ylamine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Nan Jing Dirise Chemcial Co.,LTD | 025-52161033 15312098939 | 2432674894@qq.com | China | 585 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Record Tech (Shanghai) Co., LTD | 13761627472 | 183009664@qq.com | China | 659 | 62 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 |
View Latest Price from 4,6-Dichloro-pyridin-3-ylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4,6-DICHLORO-PYRIDIN-3-YLAMINE
7321-93-9
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-03-10 | 4,6-DICHLORO-PYRIDIN-3-YLAMINE
7321-93-9
|
$6.00 | 1KG | 98% | 1kg, 10kg ,50kg | Career Henan Chemical Co |
-
- 4,6-DICHLORO-PYRIDIN-3-YLAMINE
7321-93-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4,6-DICHLORO-PYRIDIN-3-YLAMINE
7321-93-9
- $6.00
- 98%
- Career Henan Chemical Co
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