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4-Bromo-3-fluorobenzoic acid

4-Bromo-3-fluorobenzoic acid structure

CAS No.: 153556-42-4

Chemical Name:: 4-Bromo-3-fluorobenzoic acid

Synonyms: BUTTPARK 20\01-57;Fluzoparib Impurity 18;4-Bromo-3-fluorobenzoic;4-BROMO-3-FLUOROBENZOIC ACID;4-bromo-3-fluro benzoic acid;3-Fluoro-4-Bromo Benzoic Acid;Benzoic acid, 4-bromo-3-fluoro-;4-Bromo-3-fluorobenzoic acid 98%;4-Bromo-3-fluorobenzoic acid, 98+%;3-Fluoride-4-Bromine Benzoic Acids

CBNumber:: CB7496655

Molecular Formula:: C7H4BrFO2

Molecular Weight:: 219.01

MDL Number:: MFCD00672932

MOL File:: 153556-42-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:47:57

Product description	Number	Pack Size	Price
4-Bromo-3-fluorobenzoic acid Asreported	264134	25g	$390
4-Bromo-3-fluorobenzoic acid Asreported	264134	50g	$596
4-Bromo-3-fluorobenzoic acid Asreported	264134	100g	$841
4-Bromo-3-fluorobenzoic acid 98%	PC2354	5g	$21
4-Bromo-3-fluorobenzoic acid 98%	PC2354	25g	$24
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4-Bromo-3-fluorobenzoic acid Properties

Melting point	207 °C
Boiling point	296.1±25.0 °C(Predicted)
Density	1.789±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	powder
pka	3.63±0.10(Predicted)
color	Off white to cream
InChI	InChI=1S/C7H4BrFO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H,10,11)
InChIKey	RMYOGXPGIDWJLU-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC=C(Br)C(F)=C1
CAS DataBase Reference	153556-42-4(CAS DataBase Reference)
EPA Substance Registry System	Benzoic acid, 4-bromo-3-fluoro- (153556-42-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-36-22

Safety Statements

26-36/37/39

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

2916399090

NFPA 704

	0
2		0

4-Bromo-3-fluorobenzoic acid price More Price(70)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	264134	4-Bromo-3-fluorobenzoic acid Asreported	153556-42-4	25g	$390	2026-06-03	Buy
Usbiological	264134	4-Bromo-3-fluorobenzoic acid Asreported	153556-42-4	50g	$596	2026-06-03	Buy
Usbiological	264134	4-Bromo-3-fluorobenzoic acid Asreported	153556-42-4	100g	$841	2026-06-03	Buy
Apolloscientific	PC2354	4-Bromo-3-fluorobenzoic acid 98%	153556-42-4	5g	$21	2026-06-04	Buy
Apolloscientific	PC2354	4-Bromo-3-fluorobenzoic acid 98%	153556-42-4	25g	$24	2026-06-04	Buy

Product number	Packaging	Price	Buy
264134	25g	$390	Buy
264134	50g	$596	Buy
264134	100g	$841	Buy
PC2354	5g	$21	Buy
PC2354	25g	$24	Buy

4-Bromo-3-fluorobenzoic acid Chemical Properties,Uses,Production

Chemical Properties

White solid powder

Uses

4-Bromo-3-fluorobenzoic acid is an important chemical raw material and can be used to prepare a variety of drugs (such as the anticancer drug benzamide).

Synthesis

452-74-4

153556-42-4

The general procedure for the synthesis of 3-fluoro-4-bromobenzoic acid from 3-fluoro-4-bromotoluene was as follows: potassium permanganate (66.0 g, 0.42 mol) was added to a mixed solution of pyridine and water (1:1 ratio, 200 mL) containing 1-bromo-2-fluoro-4-methylbenzene (20.0 g, 0.10 mol) in batches. The reaction mixture was stirred at 90 °C for 3 hours. After completion of the reaction, it was cooled to room temperature and filtered through a diatomaceous earth pad. The diatomaceous earth pad was washed sequentially with 3N sodium hydroxide solution (500 mL) and water (400 mL). Subsequently, ethanol was removed by distillation under reduced pressure and the residue was acidified to pH=2 with 6N hydrochloric acid to produce a white precipitate. The precipitate was filtered and dried to give 4-bromo-3-fluorobenzoic acid as a white solid (17.0 g, 73% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 10, p. 1257 - 1260
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 14, p. 2973 - 2984
[3] Patent: WO2011/21209, 2011, A1. Location in patent: Page/Page column 38
[4] Patent: US2012/101099, 2012, A1. Location in patent: Page/Page column 13; 14
[5] Patent: WO2006/64251, 2006, A1. Location in patent: Page/Page column 80

4-Bromo-3-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

4-Bromo-3-fluorotoluene Hydrochloric acid Sodium hydroxide

Preparation Products

2-bromo-1-(4-bromo-3-fluorophenyl)ethanone 4-(BROMOMETHYL)-2-FLUOROBENZONITRILE 4-Cyano-3-fluorobenzoic acid 1-(4-bromo-3-fluorophenyl)propan-1-one 2-amino-4-bromo-5-fluorobenzoicacidhydrochloride

4-Bromo-3-fluorobenzoic acid Suppliers

Global( 330)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	923	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Speranza Chemical Co., Ltd.	55
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58

View Lastest Price from 4-Bromo-3-fluorobenzoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-24	4-Bromo-3-fluorobenzoic acid 153556-42-4	$110.00	1KG	98%	20 tons	Speranza Chemical Co., Ltd.
2026-03-20	4-Bromo-3-fluorobenzoic acid 153556-42-4	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2026-02-02	4-Bromo-3-fluorobenzoic acid 153556-42-4			98%	200TONS	Shaanxi Dideu Medichem Co. Ltd

4-Bromo-3-fluorobenzoic acid
153556-42-4
$110.00
98%
Speranza Chemical Co., Ltd.

4-Bromo-3-fluorobenzoic acid
153556-42-4
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Bromo-3-fluorobenzoic acid
153556-42-4
$0.10
98%
Shaanxi Dideu Medichem Co. Ltd

4-Bromo-3-fluorobenzoic acid Spectrum

4-Bromo-3-fluorobenzoic acid(153556-42-4)FT-IR

153556-42-4(4-Bromo-3-fluorobenzoic acid)Related Search:

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3-Fluoride-4-Bromine Benzoic Acids 4-BROMO-3-FLUOROBENZOIC ACID BUTTPARK 20\01-57 3-Fluoro-4-Bromo Benzoic Acid 4-Bromo-3-fluorobenzoic acid, 98+% 4-Bromo-3-fluorobenzoic acid 98% 4-Bromo-3-fluorobenzoic Benzoic acid, 4-bromo-3-fluoro- 4-bromo-3-fluro benzoic acid Fluzoparib Impurity 18 153556-42-4 Multisubstituted Benzene Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Benzoic acid Miscellaneous Acids & Esters Bromine Compounds Fluorine Compounds blocks Bromides Carboxes FluoroCompounds Fluorin-contained Benzoic acid series Fluorine series