4-Bromo-3-fluorobenzoic acid
- CAS No.
- 153556-42-4
- Chemical Name:
- 4-Bromo-3-fluorobenzoic acid
- Synonyms
- BUTTPARK 20\01-57;Fluzoparib Impurity 18;4-Bromo-3-fluorobenzoic;4-BROMO-3-FLUOROBENZOIC ACID;4-bromo-3-fluro benzoic acid;3-Fluoro-4-Bromo Benzoic Acid;Benzoic acid, 4-bromo-3-fluoro-;4-Bromo-3-fluorobenzoic acid 98%;4-Bromo-3-fluorobenzoic acid, 98+%;3-Fluoride-4-Bromine Benzoic Acids
- CBNumber:
- CB7496655
- Molecular Formula:
- C7H4BrFO2
- Molecular Weight:
- 219.01
- MDL Number:
- MFCD00672932
- MOL File:
- 153556-42-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 207 °C |
|---|---|
| Boiling point | 296.1±25.0 °C(Predicted) |
| Density | 1.789±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder |
| pka | 3.63±0.10(Predicted) |
| color | Off white to cream |
| InChI | InChI=1S/C7H4BrFO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H,10,11) |
| InChIKey | RMYOGXPGIDWJLU-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(Br)C(F)=C1 |
| CAS DataBase Reference | 153556-42-4(CAS DataBase Reference) |
| EPA Substance Registry System | Benzoic acid, 4-bromo-3-fluoro- (153556-42-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-36-22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
4-Bromo-3-fluorobenzoic acid price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 264134 | 4-Bromo-3-fluorobenzoic acid Asreported | 153556-42-4 | 25g | $390 | 2026-06-03 | Buy |
| Usbiological | 264134 | 4-Bromo-3-fluorobenzoic acid Asreported | 153556-42-4 | 50g | $596 | 2026-06-03 | Buy |
| Usbiological | 264134 | 4-Bromo-3-fluorobenzoic acid Asreported | 153556-42-4 | 100g | $841 | 2026-06-03 | Buy |
| Apolloscientific | PC2354 | 4-Bromo-3-fluorobenzoic acid 98% | 153556-42-4 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC2354 | 4-Bromo-3-fluorobenzoic acid 98% | 153556-42-4 | 25g | $24 | 2026-06-04 | Buy |
4-Bromo-3-fluorobenzoic acid Chemical Properties, Uses, Production
Chemical Properties
White solid powder
Uses
4-Bromo-3-fluorobenzoic acid is an important chemical raw material and can be used to prepare a variety of drugs (such as the anticancer drug benzamide).
Synthesis
452-74-4
153556-42-4
The general procedure for the synthesis of 3-fluoro-4-bromobenzoic acid from 3-fluoro-4-bromotoluene was as follows: potassium permanganate (66.0 g, 0.42 mol) was added to a mixed solution of pyridine and water (1:1 ratio, 200 mL) containing 1-bromo-2-fluoro-4-methylbenzene (20.0 g, 0.10 mol) in batches. The reaction mixture was stirred at 90 °C for 3 hours. After completion of the reaction, it was cooled to room temperature and filtered through a diatomaceous earth pad. The diatomaceous earth pad was washed sequentially with 3N sodium hydroxide solution (500 mL) and water (400 mL). Subsequently, ethanol was removed by distillation under reduced pressure and the residue was acidified to pH=2 with 6N hydrochloric acid to produce a white precipitate. The precipitate was filtered and dried to give 4-bromo-3-fluorobenzoic acid as a white solid (17.0 g, 73% yield).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 10, p. 1257 - 1260
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 14, p. 2973 - 2984
[3] Patent: WO2011/21209, 2011, A1. Location in patent: Page/Page column 38
[4] Patent: US2012/101099, 2012, A1. Location in patent: Page/Page column 13; 14
[5] Patent: WO2006/64251, 2006, A1. Location in patent: Page/Page column 80
4-Bromo-3-fluorobenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Tianjin Jinyuda Chemical Co., Ltd. | 022-58013646 13011382049 | sales@jinyudachem.com | China | 1976 | 55 |
| Shandong Linyao Biological Co., LTD | 15865694623 | 1825792389@qq.com | China | 15 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Latest Price from 4-Bromo-3-fluorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | 4-Bromo-3-fluorobenzoic acid
153556-42-4
|
$110.00 | 1KG | 98% | 20 tons | Speranza Chemical Co., Ltd. | |
 |
2026-03-20 | 4-Bromo-3-fluorobenzoic acid
153556-42-4
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-02-02 | 4-Bromo-3-fluorobenzoic acid
153556-42-4
|
98% | 200TONS | Shaanxi Dideu Medichem Co. Ltd |
-
- 4-Bromo-3-fluorobenzoic acid
153556-42-4
- $110.00
- 98%
- Speranza Chemical Co., Ltd.
-
- 4-Bromo-3-fluorobenzoic acid
153556-42-4
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Bromo-3-fluorobenzoic acid
153556-42-4
- $0.10
- 98%
- Shaanxi Dideu Medichem Co. Ltd
