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METHYL 4-BROMO-3-FLUOROBENZOATE 98

METHYL 4-BROMO-3-FLUOROBENZOATE 98 structure

CAS No.: 849758-12-9

Chemical Name:: METHYL 4-BROMO-3-FLUOROBENZOATE 98

Synonyms: Bromo-3-fluorobenzoate;4-bromo-3-fluorobenzoate methyl;4-bromo-3-fluoro-2-methylbenzoate;METHYL 4-BROMO-3-FLUOROBENZOATE 98;Methyl 4-bromo-3-fluorobenzoate 98%;Benzoicacid, 4-broMo-3-fluoro-, Methyl ester

CBNumber:: CB4501116

Molecular Formula:: C8H6BrFO2

Molecular Weight:: 233.03

MDL Number:: MFCD08436044

MOL File:: 849758-12-9.mol

Last updated:2025-07-24 18:13:54

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METHYL 4-BROMO-3-FLUOROBENZOATE 98 Properties

Melting point	64-66
Boiling point	270.1±25.0 °C(Predicted)
Density	1.577±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
color	White to Light yellow
InChI	InChI=1S/C8H6BrFO2/c1-12-8(11)5-2-3-6(9)7(10)4-5/h2-4H,1H3
InChIKey	WDAFDKXHLVMFKA-UHFFFAOYSA-N
SMILES	C(OC)(=O)C1=CC=C(Br)C(F)=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes

RIDADR

2811

Hazard Note

Irritant/Keep Cold

HazardClass

6.1

PackingGroup

Ⅲ

HS Code

2916310090

NFPA 704

	0
2		0

METHYL 4-BROMO-3-FLUOROBENZOATE 98 price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M3083	Methyl 4-Bromo-3-fluorobenzoate >98.0%(GC)	849758-12-9	5g	$91	2025-07-31	Buy
TCI Chemical	M3083	Methyl 4-Bromo-3-fluorobenzoate >98.0%(GC)	849758-12-9	25g	$361	2025-07-31	Buy
TRC	M295910	Methyl 4-Bromo-3-fluorobenzoate	849758-12-9	1g	$75	2021-12-16	Buy
SynQuest Laboratories	2623-B-X2	Methyl 4-bromo-3-fluorobenzoate 98%	849758-12-9	5G	$80	2021-12-16	Buy
AK Scientific	Z5184	Methyl 4-Bromo-3-fluorobenzoate	849758-12-9	1g	$26	2021-12-16	Buy

Product number	Packaging	Price	Buy
M3083	5g	$91	Buy
M3083	25g	$361	Buy
M295910	1g	$75	Buy
2623-B-X2	5G	$80	Buy
Z5184	1g	$26	Buy

METHYL 4-BROMO-3-FLUOROBENZOATE 98 Chemical Properties,Uses,Production

Chemical Properties

off-white powder

Synthesis

67-56-1

153556-42-4

849758-12-9

Step 2: Under nitrogen protection, 1-methylpiperazine (980 μL, 8.80 mmol) was dissolved in toluene (15 mL), and tris (dibenzylideneacetone) dipalladium (201 mg, 0.22 mmol), BINAP (550 mg, 0.88 mmol), and cesium carbonate (4.30 g, 13.2 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 30 min before adding methyl 4-bromo-3-fluorobenzoate (2.05 g, 8.80 mmol). Subsequently, the reaction system was heated to 105 °C with continuous stirring for 18 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered through a diatomaceous earth pad and the filter cake was washed with ethyl acetate. The filtrates were combined and concentrated under reduced pressure to give an orange oily crude product. The crude product was purified by silica gel column chromatography using 5% dichloromethane solution of methanol as eluent. The target fraction was collected and concentrated under reduced pressure to afford methyl 3-fluoro-4-(4-methylpiperazin-1-yl)benzoate (1.80 g, 81%) as a colorless oil. The structure of the product was confirmed by 1H NMR (400 MHz, CD3OD) and mass spectrometry (EI): 1H NMR (400 MHz, CD3OD): δ 7.78-7.73 (d, 1H), 7.64-7.59 (d, 1H), 7.09-7.03 (m, 1H), 3.86 (s, 3H), 3.26-3.20 (m, 4H), 2.65-2.59 (m, 4H), 2.35 (s, 3H). MS (EI): m/z 253 (MH+).

References

[1] Patent: US2010/216806, 2010, A1. Location in patent: Page/Page column 103
[2] Patent: WO2009/55077, 2009, A1. Location in patent: Page/Page column 369
[3] Patent: US2009/23748, 2009, A1. Location in patent: Page/Page column 21
[4] Patent: US2012/230951, 2012, A1. Location in patent: Page/Page column 97-98
[5] Patent: WO2016/20836, 2016, A1. Location in patent: Page/Page column 101; 102

METHYL 4-BROMO-3-FLUOROBENZOATE 98 Preparation Products And Raw materials

Raw materials

Methanol 4-Bromo-3-fluorobenzoic acid Iodomethane (TRIMETHYLSILYL)DIAZOMETHANE

Preparation Products

2-FLUORO-4-(METHOXYCARBONYL)BENZENEBORONIC ACID

METHYL 4-BROMO-3-FLUOROBENZOATE 98 Suppliers

Global( 152)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Guangzhou CATO Research Chemicals Inc.	+86-020-81960175-617 +8615602392859	Intermediate@cato-chem.com	China	6428	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8285	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29733	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49730	58

Supplier	Advantage
Guangzhou CATO Research Chemicals Inc.	58
Shanghai UCHEM Inc.	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Nanjing Dolon Biotechnology Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
Shenzhen Excellent Biotech Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from METHYL 4-BROMO-3-FLUOROBENZOATE 98 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-20	Methyl 4-bromo-3-fluorobenzoate 849758-12-9	US $16.00-166.00 / g	5g	0.98	25kg	Shanghai UCHEM Inc.
2025-01-03	Methyl 4-bromo-3-fluorobenzoate 849758-12-9	US $0.00-0.00 / KG	5mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
2019-12-20	METHYL 4-BROMO-3-FLUOROBENZOATE 98 849758-12-9	US $1.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

Methyl 4-bromo-3-fluorobenzoate
849758-12-9
US $16.00-166.00 / g
0.98
Shanghai UCHEM Inc.

Methyl 4-bromo-3-fluorobenzoate
849758-12-9
US $0.00-0.00 / KG
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

METHYL 4-BROMO-3-FLUOROBENZOATE 98
849758-12-9
US $1.00 / KG
99%
Career Henan Chemical Co

METHYL 4-BROMO-3-FLUOROBENZOATE 98 Spectrum

METHYL 4-BROMO-3-FLUOROBENZOATE 98(849758-12-9)¹HNMR

849758-12-9(METHYL 4-BROMO-3-FLUOROBENZOATE 98)Related Search:

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4-bromo-3-fluoro-2-methylbenzoate METHYL 4-BROMO-3-FLUOROBENZOATE 98 Methyl 4-bromo-3-fluorobenzoate 98% Benzoicacid, 4-broMo-3-fluoro-, Methyl ester Bromo-3-fluorobenzoate 4-bromo-3-fluorobenzoate methyl 849758-12-9 C8H6BrF2 Fluorine series blocks Bromides Carboxes