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Methyl 4-bromo-3-fluorobenzoate 98

Methyl 4-bromo-3-fluorobenzoate 98 structure

CAS No.: 849758-12-9

Chemical Name:: Methyl 4-bromo-3-fluorobenzoate 98

Synonyms: Bromo-3-fluorobenzoate;4-bromo-3-fluorobenzoate methyl;4-bromo-3-fluoro-2-methylbenzoat;4-bromo-3-fluoro-2-methylbenzoate;Methyl 4-bromo-3-fluorobenzoate 98;Methyl 4-bromo-3-fluorobenzoate 98%;Benzoicacid, 4-broMo-3-fluoro-, Methyl ester

CBNumber:: CB4501116

Molecular Formula:: C8H6BrFO2

Molecular Weight:: 233.03

MDL Number:: MFCD08436044

MOL File:: 849758-12-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:52

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Methyl 4-bromo-3-fluorobenzoate 98 Properties

Melting point	64-66
Boiling point	270.1±25.0 °C(Predicted)
Density	1.577±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
color	White to Light yellow
InChI	InChI=1S/C8H6BrFO2/c1-12-8(11)5-2-3-6(9)7(10)4-5/h2-4H,1H3
InChIKey	WDAFDKXHLVMFKA-UHFFFAOYSA-N
SMILES	C(OC)(=O)C1=CC=C(Br)C(F)=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes

RIDADR

2811

Hazard Note

Irritant/Keep Cold

HazardClass

6.1

PackingGroup

Ⅲ

HS Code

2916310090

NFPA 704

	0
2		0

Methyl 4-bromo-3-fluorobenzoate 98 price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M3083	Methyl 4-Bromo-3-fluorobenzoate >98.0%(GC)	849758-12-9	5g	$97	2026-04-30	Buy
TCI Chemical	M3083	Methyl 4-Bromo-3-fluorobenzoate >98.0%(GC)	849758-12-9	25g	$385	2026-04-30	Buy
Apolloscientific	PC3584	Methyl 4-bromo-3-fluorobenzoate 98%	849758-12-9	5g	$29	2026-06-04	Buy
Apolloscientific	PC3584	Methyl 4-bromo-3-fluorobenzoate 98%	849758-12-9	25g	$104	2026-06-04	Buy
Apolloscientific	PC3584	Methyl 4-bromo-3-fluorobenzoate 98%	849758-12-9	100g	$311	2026-06-04	Buy

Product number	Packaging	Price	Buy
M3083	5g	$97	Buy
M3083	25g	$385	Buy
PC3584	5g	$29	Buy
PC3584	25g	$104	Buy
PC3584	100g	$311	Buy

Methyl 4-bromo-3-fluorobenzoate 98 Chemical Properties,Uses,Production

Uses

Methyl 4-bromo-3-fluorobenzoate is a carboxylic acid ester derivative and an intermediate in the preparation of various drugs.

Chemical Properties

off-white powder

Synthesis

67-56-1

153556-42-4

849758-12-9

Step 2: Under nitrogen protection, 1-methylpiperazine (980 μL, 8.80 mmol) was dissolved in toluene (15 mL), and tris (dibenzylideneacetone) dipalladium (201 mg, 0.22 mmol), BINAP (550 mg, 0.88 mmol), and cesium carbonate (4.30 g, 13.2 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 30 min before adding methyl 4-bromo-3-fluorobenzoate (2.05 g, 8.80 mmol). Subsequently, the reaction system was heated to 105 °C with continuous stirring for 18 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered through a diatomaceous earth pad and the filter cake was washed with ethyl acetate. The filtrates were combined and concentrated under reduced pressure to give an orange oily crude product. The crude product was purified by silica gel column chromatography using 5% dichloromethane solution of methanol as eluent. The target fraction was collected and concentrated under reduced pressure to afford methyl 3-fluoro-4-(4-methylpiperazin-1-yl)benzoate (1.80 g, 81%) as a colorless oil. The structure of the product was confirmed by 1H NMR (400 MHz, CD3OD) and mass spectrometry (EI): 1H NMR (400 MHz, CD3OD): δ 7.78-7.73 (d, 1H), 7.64-7.59 (d, 1H), 7.09-7.03 (m, 1H), 3.86 (s, 3H), 3.26-3.20 (m, 4H), 2.65-2.59 (m, 4H), 2.35 (s, 3H). MS (EI): m/z 253 (MH+).

References

[1] Patent: US2010/216806, 2010, A1. Location in patent: Page/Page column 103
[2] Patent: WO2009/55077, 2009, A1. Location in patent: Page/Page column 369
[3] Patent: US2009/23748, 2009, A1. Location in patent: Page/Page column 21
[4] Patent: US2012/230951, 2012, A1. Location in patent: Page/Page column 97-98
[5] Patent: WO2016/20836, 2016, A1. Location in patent: Page/Page column 101; 102

Methyl 4-bromo-3-fluorobenzoate 98 Preparation Products And Raw materials

Raw materials

Methanol 4-Bromo-3-fluorobenzoic acid Iodomethane (Trimethylsilyl)diazomethane

Preparation Products

2-Fluoro-4-(methoxycarbonyl)benzeneboronic acid

Methyl 4-bromo-3-fluorobenzoate 98 Suppliers

Global( 152)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
New Energy Chemicals	0515-82159099 13770142076	info@njuchem.com	China	251	65
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 13582355795	master@sjzsdyn.com	China	2776	65
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
New Energy Chemicals	65
Energy Chemical	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65
Wuhan Chemwish Technology Co., Ltd	56
Adamas Reagent, Ltd.	59
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Shandong Xiya Chemical Co., Ltd	57

View Lastest Price from Methyl 4-bromo-3-fluorobenzoate 98 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-14	Methyl 4-bromo-3-fluorobenzoate 849758-12-9	$16.00-166.00	5g	0.98	25kg	Shanghai UCHEM Inc.
2026-02-02	Methyl 4-bromo-3-fluorobenzoate 849758-12-9		5mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
2019-12-20	METHYL 4-BROMO-3-FLUOROBENZOATE 98 849758-12-9	$1.00	1KG	99%	100kg	Career Henan Chemical Co

Methyl 4-bromo-3-fluorobenzoate
849758-12-9
$16.00-166.00
0.98
Shanghai UCHEM Inc.

Methyl 4-bromo-3-fluorobenzoate
849758-12-9
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

METHYL 4-BROMO-3-FLUOROBENZOATE 98
849758-12-9
$1.00
99%
Career Henan Chemical Co

Methyl 4-bromo-3-fluorobenzoate 98 Spectrum

METHYL 4-BROMO-3-FLUOROBENZOATE 98(849758-12-9)¹HNMR

849758-12-9(Methyl 4-bromo-3-fluorobenzoate 98)Related Search:

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4-bromo-3-fluoro-2-methylbenzoate Methyl 4-bromo-3-fluorobenzoate 98% Benzoicacid, 4-broMo-3-fluoro-, Methyl ester Bromo-3-fluorobenzoate 4-bromo-3-fluorobenzoate methyl 4-bromo-3-fluoro-2-methylbenzoat Methyl 4-bromo-3-fluorobenzoate 98 849758-12-9 C8H6BrF2 Fluorine series blocks Bromides Carboxes