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2-Chloro-4-methyl-5-nitropyridine

2-Chloro-4-methyl-5-nitropyridine structure

CAS No.: 23056-33-9

Chemical Name:: 2-Chloro-4-methyl-5-nitropyridine

Synonyms: 2-chloro-4-methyl-;3-chloro-4-methyl-5-nitropyridine;-5-nitropyridine;5-Nitro-2-chloro-4-picoline;2-CHLORO-5-NITRO-4-PICOLINE;2-Chloro-4-Methyl-5-nitro...;2-CHLORO-5-NITRO-4-PICOLINE 98+%;2-CHLORO-5-NITRO-4-METHYLPYRIDINE;2-CHLORO-4-METHYL-5-NITROPYRIDINE;2-CHIORO-4-METHYL-5-NITROPYRIDINE

CBNumber:: CB7433106

Molecular Formula:: C6H5ClN2O2

Molecular Weight:: 172.57

MDL Number:: MFCD00010688

MOL File:: 23056-33-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:30:42

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2-Chloro-4-methyl-5-nitropyridine Properties

Melting point	37-39 °C (lit.)
Boiling point	91 °C/5 mmHg (lit.)
Density	1.5610 (rough estimate)
refractive index	1.5870 (estimate)
Flash point	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	Crystalline Powder or Chunks
pka	-3.42±0.10(Predicted)
color	Light cream to light brown
InChI	InChI=1S/C6H5ClN2O2/c1-4-2-6(7)8-3-5(4)9(10)11/h2-3H,1H3
InChIKey	HWZUMEVIIGNXGM-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C([N+]([O-])=O)C(C)=C1
CAS DataBase Reference	23056-33-9(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-20/21/22

Safety Statements

26-37/39-36/37/39-36

WGK Germany

HazardClass

IRRITANT

HS Code

29333999

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
0		0

2-Chloro-4-methyl-5-nitropyridine price More Price(69)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	290122	2-Chloro-4-methyl-5-nitropyridine 97%	23056-33-9	1g	$74.4	2023-01-07	Buy
TCI Chemical	C2021	2-Chloro-4-methyl-5-nitropyridine >98.0%(GC)	23056-33-9	1g	$27	2026-04-30	Buy
TCI Chemical	C2021	2-Chloro-4-methyl-5-nitropyridine >98.0%(GC)	23056-33-9	5g	$80	2026-04-30	Buy
Usbiological	270229	2-Chloro-4-methyl-5-nitropyridine Asreported	23056-33-9	10g	$369	2026-06-03	Buy
Usbiological	270229	2-Chloro-4-methyl-5-nitropyridine Asreported	23056-33-9	25g	$588	2026-06-03	Buy

Product number	Packaging	Price	Buy
290122	1g	$74.4	Buy
C2021	1g	$27	Buy
C2021	5g	$80	Buy
270229	10g	$369	Buy
270229	25g	$588	Buy

2-Chloro-4-methyl-5-nitropyridine Chemical Properties, Uses, Production

Chemical Properties

light cream to light brown crystalline powder

Uses

2-Chloro-4-methyl-5-nitropyridine may be used in chemical synthesis studies.

Synthesis

21901-41-7

23056-33-9

General procedure for the synthesis of 2-chloro-5-nitro-4-methylpyridine from 2-hydroxy-4-methyl-5-nitropyridine: 1. 2-Hydroxy-4-methyl-5-nitropyridine (500 mg, 3.24 mmol), POCl3 (0.5 mL) and PCl5 (200 mg) were mixed and stirred at 150°C for 2 hrs. 2. After completion of the reaction, cooled to room temperature, the reaction mixture was poured into ice and extracted with dichloromethane (DCM, 3 x 20 mL). 3. The organic phases were combined, washed with water to pH 7, dried over Na2SO4 and concentrated under reduced pressure. 4. The obtained residue was dried under reduced pressure to give the crude product 2-chloro-4-methyl-5-nitropyridine (480 mg, 86% yield). In the presence of PdCl2(PPh3)2 (42 mg, 0.06 mmol), P(t-Bu)3 (16 mg, 0.08 mmol) and TEA (1.5 mL), 2-chloro-4-methyl-5-nitropyridine (172 mg, 1.00 mmol) was mixed with 3-ethynyl-7,7-dimethyl-7,8-dihydroquinolin-5(6H)-one (199 mg, 1.00 mmol) in DMF (3 mL) at 100°C for 3 hours. The crude product was purified by column chromatography (silica gel) to afford the intermediate 7,7-dimethyl-3-((4-methyl-5-nitropyridin-2-yl)ethynyl)-7,8-dihydroquinolin-5(6H)-one (115 mg, 34% yield). A solution of 7,7-dimethyl-3-((4-methyl-5-nitropyridin-2-yl)ethynyl)-7,8-dihydroquinolin-5(6H)-one (114 mg, 0.34 mmol) and SnCl2-2H2O (380 mg, 1.70 mmol) in EtOH (10 mL) was stirred at reflux for 6 hours. After completion of the reaction, it was cooled to room temperature, poured into ice, adjusted to pH 7-8 with saturated aqueous NaHCO3 solution and extracted with EtOAc (3 × 30 mL). The organic phases were combined, dried over Na2SO4 and concentrated under reduced pressure. The resulting residue was purified by washing with hexane and acetonitrile to afford the target product 2-chloro-5-nitro-4-methylpyridine (60 mg, 58% yield). 1H NMR (DMSO-d6) δ: 1.07 (s, 6H), 2.08 (s, 3H), 2.60 (s, 2H), 3.02 (s, 2H), 5.51 (s, 2H), 7.23 (s, 1H), 7.90 (s, 1H), 8.17 (s, 1H), 8.80 (s, 1H). LC/MS (M+H)+ = 306.

References

[1] Patent: WO2012/52451, 2012, A1. Location in patent: Page/Page column 117-118
[2] Journal of Organic Chemistry, 1955, vol. 20, p. 1729,1731
[3] Journal of the Chemical Society, 1954, p. 1190,1192
[4] Journal of the Chemical Society, 1954, p. 2448,2455
[5] Patent: WO2007/53394, 2007, A1. Location in patent: Page/Page column 12

2-Chloro-4-methyl-5-nitropyridine synthesis

Synthesis of 2-Chloro-4-methyl-5-nitropyridine from 2-Hydroxy-4-methyl-5-nitropyridine

2-Chloro-4-methyl-5-nitropyridine Preparation Products And Raw materials

Raw materials

2-Hydroxy-4-methyl-5-nitropyridine 2-Amino-5-nitro-4-picoline 2-Chloro-4-methyl-3-nitropyridine 4-Methylpyridin-2-amine

Preparation Products

5-Methoxy-1H-pyrrolo[2,3-c]pyridine-2-carbaldehyde 5-Methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid 3-Fluoropyridine-4-carboxylic acid 5-Acetylamino-2-chloro-4-picoline 4-Pyridinecarboxylicacid,5-amino-2-methyl-(9CI)

ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 2-Methoxy-5-nitro-4-picoline 4-{5-nitro-4-methyl-2-pyridinyl}morpholine Ethyl 3-(2-chloro-5-nitropyridin-4-yl)-2-oxopropanoate 1H-Pyrrolo[2,3-c]pyridine, 5-(3-pyridinyl)-

5-Chloro-1-(phenylsulfonyl)-6-azaindole

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2-Chloro-4-methyl-5-nitropyridine Suppliers

Global Suppliers ( 409)

Supplier	Tel	Email	Country	ProdList	Advantage
Ningbo Fuhe Chemical Co., Ltd.	0574-1806900 18069001216	nbfjj@126.com	China	99	58
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Liaoning Tianhua Chemical Co., Ltd.	0418-6530555 2855550		China	338	69
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
ChemFuture PharmaTech (Jiangsu) Ltd	5108538618	suger.wang@chemfuture.com	China	832	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Ningbo Fuhe Chemical Co., Ltd.	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Liaoning Tianhua Chemical Co., Ltd.	69
INTATRADE GmbH	66
3B Pharmachem (Wuhan) International Co.,Ltd.	69
ChemFuture PharmaTech (Jiangsu) Ltd	65
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81

View Latest Price from 2-Chloro-4-methyl-5-nitropyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	2-Chloro-4-methyl-5-nitropyridine 23056-33-9	$5.00	1KG	98%		Henan Fengda Chemical Co., Ltd
2026-08-20	2-Chloro-4-methyl-5-nitropyridine 23056-33-9	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2026-06-30	2-Chloro-4-methyl-5-nitropyridine 23056-33-9		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

2-Chloro-4-methyl-5-nitropyridine
23056-33-9
$5.00
98%
Henan Fengda Chemical Co., Ltd

2-Chloro-4-methyl-5-nitropyridine
23056-33-9
$1.10
99.00%
Dideu Industries Group Limited

2-Chloro-4-methyl-5-nitropyridine
23056-33-9
98.0%
Shaanxi Dideu New Materials Co. Ltd

2-Chloro-4-methyl-5-nitropyridine Spectrum

2-Chloro-4-methyl-5-nitropyridine(23056-33-9)MS 2-Chloro-4-methyl-5-nitropyridine(23056-33-9)¹HNMR 2-Chloro-4-methyl-5-nitropyridine(23056-33-9)¹³CNMR 2-Chloro-4-methyl-5-nitropyridine(23056-33-9)IR1 2-Chloro-4-methyl-5-nitropyridine(23056-33-9)IR2 2-Chloro-4-methyl-5-nitropyridine(23056-33-9)Raman

23056-33-9 (2-Chloro-4-methyl-5-nitropyridine) Related Search:

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2-CHIORO-4-METHYL-5-NITROPYRIDINE 2-CHLORO-5-NITRO-4-PICOLINE 98+% 2-CHLORO-5-NITRO-4-PICOLINE (2-CHLORO-4-METHYL-5-NITROPYRIDINE) 2-CHLORO-4-METHYL-5-NITROPYRIDINE 2-CHLORO-5-NITRO-4-METHYLPYRIDINE 2-CHLORO-5-NITRO-4-PICOLINE 2-chloro-4-methyl-5-nitroppyridine 3-chloro-4-methyl-5-nitropyridine 2-Chloro-4-methyl-5-nitropyridine ,98% 5-Nitro-2-chloro-4-picoline Pyridine, 2-chloro-4-methyl-5-nitro- 2-Chloro-4-Methyl-5- nitropyridine, 2-Chloro-5-nitro-4-picoline 2-Chloro-4-Methyl-5-nitropyridine, 97+% 2-Chloro-4-Methyl-5-nitro... 2-Chloro-4-methyl-5-nitropyridine > -5-nitropyridine 2-Chloro-4-methyl-5-nitropyridine ISO 9001：2015 REACH 2-chloro-4-methyl- 23056-33-9 3056-33-9 23059-33-9 21056-33-9 23056-33-0 23056-39-7 C6H5C1N2O2 Building Blocks Halopyridines Chloropyridines Halogenated Heterocycles Heterocyclic Building Blocks Pyridines Heterocycle-Pyridine series nitro-compound| alkyl chloride Chlorinated heterocyclic series pyridine series C6Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Boronic Acid Chloropyridines Halopyridines Pyridines Pyridine Derivertives Pyridine compounds of pyridine