Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
- CAS No.
- 1835705-76-4
- Chemical Name:
- Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
- Synonyms
- Pomalidomide-6-5-6-I;Pomalidomide-C?-PEG?-C?-PEG?-butyl iodide;Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide;Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide;N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-6-({5-[(6-iodohexyl)oxy]pentyl}oxy)hexanamide;Hexanamide, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-6-[[5-[(6-iodohexyl)oxy]pentyl]oxy]-;Crosslinker?E3 Ligase ligand conjugate, Pomalidomide-6-5-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-6-((5-((6-iodohexyl)oxy)pentyl)oxy)hexanamide, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
- CBNumber:
- CB95430588
- Molecular Formula:
- C30H42IN3O7
- Molecular Weight:
- 683.57
- MDL Number:
- MOL File:
- 1835705-76-4.mol
- MSDS File:
- SDS
| Boiling point | 809.7±65.0 °C(Predicted) |
|---|---|
| Density | 1.412±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 10.69±0.40(Predicted) |
| form | powder or crystals |
| InChIKey | ABEUETLCTXKUSX-UHFFFAOYSA-N |
| SMILES | ICCCCCCOCCCCCOCCCCCC(NC1=CC=CC2=C1C(N(C3CCC(NC3=O)=O)C2=O)=O)=O |
| UNSPSC Code | 12352101 |
| NACRES | NA.22 |
Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide price
Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Chemical Properties, Uses, Production
Uses
Protein degrader builiding block Pomalidomide-C6-PEG1-C3-PEG1-Butyl Iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
reaction suitability
reactivity: sulfuryl reactive
reagent type: ligand-linker conjugate
Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Preparation Products And Raw materials
Raw materials
Preparation Products
Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4229 | 58 |
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1644 | 58 |
| Changsha Bono New Materials Technology Co., Ltd. | 18191076804 | asherw9@hotmail.com | China | 2373 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 9067 | 58 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 | 1924344760@confluore.cn | China | 3000 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
View Latest Price from Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-07 | Pomalidomide-6-5-6-I
1835705-76-4
|
100mg | >95.00% | 100mg | Xian confluore Biological Technology Co., Ltd. |
-
- Pomalidomide-6-5-6-I
1835705-76-4
- $0.00
- >95.00%
- Xian confluore Biological Technology Co., Ltd.
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