(R)-3-Hydroxypyrrolidine
- CAS No.
- 2799-21-5
- Chemical Name:
- (R)-3-Hydroxypyrrolidine
- Synonyms
- (R)-PYRROLIDIN-3-OL;(R)-3-PYRROLIDINOL;(3R)-Pyrrolidin-3-ol;(R)-Hydroxypyrrolidine;R-HP;98%，ee99%;(-)-3-Pyrrolidinol;(3R)-3-PYRROLIDINOL;3-PYRROLIDINOL, (R);(R)-Pyrrolidine-3-ol
- CBNumber:
- CB7494161
- Molecular Formula:
- C4H9NO
- Molecular Weight:
- 87.12
- MDL Number:
- MFCD00145220
- MOL File:
- 2799-21-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 15°C |
|---|---|
| alpha | 6.5 º (c=3.5% in MeOH) |
| Boiling point | 215-216 °C (lit.) |
| Density | 1.078 g/mL at 20 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Viscous Liquid |
| pka | 14.91±0.20(Predicted) |
| Specific Gravity | 1.048 |
| color | Clear yellow to orange-brown |
| optical activity | [α]20/D +6.5°, c = 3.5 in methanol |
| Water Solubility | Soluble in water and methanol. |
| Sensitive | Air Sensitive & Hygroscopic |
| BRN | 5376132 |
| InChI | 1S/C4H9NO/c6-4-1-2-5-3-4/h4-6H,1-3H2/t4-/m1/s1 |
| InChIKey | JHHZLHWJQPUNKB-SCSAIBSYSA-N |
| SMILES | O[C@@H]1CCNC1 |
| CAS DataBase Reference | 2799-21-5(CAS DataBase Reference) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P321-P332+P313-P337+P313-P261-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-34 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
(R)-3-Hydroxypyrrolidine price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 382981 | (R)-3-Pyrrolidinol 98% | 2799-21-5 | 1g | $85.4 | 2023-01-07 | Buy |
| Sigma-Aldrich | 382981 | (R)-3-Pyrrolidinol 98% | 2799-21-5 | 5g | $137 | 2023-01-07 | Buy |
| TCI Chemical | P1608 | (R)-3-Pyrrolidinol >98.0%(GC) | 2799-21-5 | 1g | $45 | 2026-04-30 | Buy |
| TCI Chemical | P1608 | (R)-3-Pyrrolidinol >98.0%(GC) | 2799-21-5 | 5g | $136 | 2026-04-30 | Buy |
| Usbiological | 279960 | (R)-3-Hydroxypyrrolidine Asreported | 2799-21-5 | 5g | $396 | 2026-06-03 | Buy |
(R)-3-Hydroxypyrrolidine Chemical Properties,Uses,Production
Chemical Properties
clear yellow to orange-brown viscous liquid
Uses
(R)-Pyrrolidin-3-ol is used in preparation of allosteric BCR-ABL bifunctional proteolysis targeting chimera compounds.
Synthesis
51-35-4
40499-83-0
The general procedure for the synthesis of 3-hydroxypyrrolidine from L-hydroxyproline is as follows: Example 1: Synthesis of (R)-3-pyrrolidinol To a 1 liter reaction vessel was added (4R)-hydroxy-L-proline (250 g, 1.907 mol), 2-cyclohexen-1-one (18.3 g, 0.1907 mol), and polyethylene glycol (750 mL, 400 average molar mass). The reaction was carried out by stirring the mixture under nitrogen protection at 150-160 °C. After 10 h, the reaction was judged complete when the reaction mixture changed from a suspension to a homogeneous phase. The yield of (R)-3-pyrrolidinol was 89.3% as determined by gas chromatographic analysis. Subsequently, the reaction solution was subjected to decompression distillation at the same temperature to collect fractions with boiling points of 100-120 °C (pressure 6-40 hPa) to give (R)-3-pyrrolidinol (120.4 g, 72.5% yield, 99.6% chemical purity, 99.9% optical purity ee).
Purification Methods
The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]
References
[1] Chemistry Letters, 1986, p. 893 - 896
[2] Patent: CN105153133, 2018, B. Location in patent: Paragraph 0022; 0023; 0024; 0025; 0026
[3] Synthetic Communications, 1993, vol. 23, # 19, p. 2691 - 2699
[4] Synthetic Communications, 1994, vol. 24, # 10, p. 1381 - 1387
[5] Patent: US2005/222430, 2005, A1. Location in patent: Page/Page column 2
(R)-3-Hydroxypyrrolidine Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BTC Pharmaceutical CO. Ltd | +86-15716293042 15716293042 | info@btcpharm.com | China | 823 | 55 |
| Anhui Dexinjia Biopharm Co., Ltd | 0531-82375893 15553111391 | phoebe@jndxj.com | China | 285 | 58 |
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 423 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
View Lastest Price from (R)-3-Hydroxypyrrolidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | (R)-3-Hydroxypyrrolidine
2799-21-5
|
$1.20-34.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-25 | (R)-3-Hydroxypyrrolidine
2799-21-5
|
$80.00-800.00 | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2026-07-30 | (R)-3-Hydroxypyrrolidine
2799-21-5
|
$100.00 | 1kg | not less than 98% | 20tons per month | Anhui Dexinjia Biopharm Co., Ltd |
-
- (R)-3-Hydroxypyrrolidine
2799-21-5
- $1.20-34.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- (R)-3-Hydroxypyrrolidine
2799-21-5
- $80.00-800.00
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- (R)-3-Hydroxypyrrolidine
2799-21-5
- $100.00
- not less than 98%
- Anhui Dexinjia Biopharm Co., Ltd
