2-Chloro-3-cyano-4,6-dimethylpyridine
- CAS No.
- 14237-71-9
- Chemical Name:
- 2-Chloro-3-cyano-4,6-dimethylpyridine
- Synonyms
- 2-CHLORO-4,6-DIMETHYLNICOTINONITRILE;EOS-60842;AKOS BC-3128;BUTTPARK 59\40-61;AKOS BBS-00002510;IFLAB-BB F1371-0162;Opicapone Impurity 20;6-diMethylnicotinonitrile;2-CHLORO-3-CYANO-4,6-DIMETHYLPYRIDINE;2-Chloro-3-cyano-4,6-dimethylpyridine,98%
- CBNumber:
- CB7713273
- Molecular Formula:
- C8H7ClN2
- Molecular Weight:
- 166.61
- MDL Number:
- MFCD00051676
- MOL File:
- 14237-71-9.mol
- MSDS File:
- SDS
| Melting point | 98-99°C |
|---|---|
| Boiling point | 305.3±37.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to crystal |
| pka | -0.41±0.10(Predicted) |
| color | White to Almost white |
| BRN | 131348 |
| InChI | InChI=1S/C8H7ClN2/c1-5-3-6(2)11-8(9)7(5)4-10/h3H,1-2H3 |
| InChIKey | RETJKTAVEQPNMH-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(C)=CC(C)=C1C#N |
| CAS DataBase Reference | 14237-71-9(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P310-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36/37/38-41-37/38-25 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | 3276 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Chloro-3-cyano-4,6-dimethylpyridine price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 700606 | 2-Chloro-4,6-dimethylpyridine-3-carbonitrile 97% | 14237-71-9 | 5g | $64.5 | 2023-01-07 | Buy |
| Sigma-Aldrich | 700606 | 2-Chloro-4,6-dimethylpyridine-3-carbonitrile 97% | 14237-71-9 | 25g | $287 | 2023-01-07 | Buy |
| TCI Chemical | C2668 | 2-Chloro-4,6-dimethyl-3-pyridinecarbonitrile >98.0%(GC) | 14237-71-9 | 5g | $31 | 2026-04-30 | Buy |
| TCI Chemical | C2668 | 2-Chloro-4,6-dimethyl-3-pyridinecarbonitrile >98.0%(GC) | 14237-71-9 | 25g | $155 | 2026-04-30 | Buy |
| Usbiological | 230147 | 2-Chloro-4,6-dimethylpyridine-3-carbonitrile | 14237-71-9 | 1g | $162 | 2026-06-03 | Buy |
2-Chloro-3-cyano-4,6-dimethylpyridine Chemical Properties, Uses, Production
Uses
2-Chloro-3-cyano-4,6-dimethylpyridine is mainly used as an organic synthesis intermediate and can be used to prepare polysubstituted pyridine bioactive molecules. For example, there are patent reports that this substance can be used to synthesize protein kinase (CDK) inhibitors.
Chemical Properties
White to brown solid
Synthesis
769-28-8
14237-71-9
Example 6 Synthesis of 3-(5-phenyl-2,4-dimethyl-6-oxo-1,6-dihydropyrimidin-3-yl)benzonitrile Step 1: Preparation of 2-chloro-3-cyano-4,6-dimethylpyridine: In a reaction flask, 3-cyano-4,6-dimethyl-2-hydroxypyridine (4.35 g, 29.39 mmol) was mixed with phosphorus pentachloride (6.92 g, 33.21 mmol) were mixed and heated to 120 °C with continuous stirring. The reaction mixture gradually changed to a clarified solution and stirring was continued for 1 hour to ensure complete reaction. Subsequently, the reaction mixture was slowly poured into a pre-prepared ice/water mixture (250 mL) and allowed to stand for 30 minutes to complete hydrolysis. The aqueous phase was adjusted to pH 6 with sodium bicarbonate and then extracted with dichloromethane (400 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the crude product 2-chloro-3-cyano-4,6-dimethylpyridine (4.60 g, 94% yield) as a brown solid, which was analyzed to contain about 15% impurities. The product was characterized by LC/MS and NMR: LC/MS showed m/e = 167/169 (M + H) with a retention time of 2.98 min; 1H NMR (CDCl3, 400 MHz) δ 7.08 (s, 1H), 2.57 (s, 3H), 2.55 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 10, p. 1887 - 1897
[2] Patent: WO2005/97750, 2005, A1. Location in patent: Page/Page column 75
[3] Chemistry of Heterocyclic Compounds, 2009, vol. 45, # 1, p. 35 - 41
[4] Journal of Heterocyclic Chemistry, 2013, vol. 50, # SUPPL.1, p. E12-E17
[5] Journal of the American Chemical Society, 1949, vol. 71, p. 331
2-Chloro-3-cyano-4,6-dimethylpyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xinyi Kaiwu Chemical Technology Co., Ltd. | 0516-0516-88997009 18651776937 | 4164357@qq.com | China | 3204 | 58 |
| Nanjing Habo Medical Technology Co., Ltd. | 13376080562 13376090521 | sales@habotech.com | China | 724 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
View Latest Price from 2-Chloro-3-cyano-4,6-dimethylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 2-Chloro-3-cyano-4,6-dimethylpyridine
14237-71-9
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 2-Chloro-3-cyano-4,6-dimethylpyridine
14237-71-9
|
$1.00 | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- 2-Chloro-3-cyano-4,6-dimethylpyridine
14237-71-9
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Chloro-3-cyano-4,6-dimethylpyridine
14237-71-9
- $1.00
- 98%
- Career Henan Chemical Co
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