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2'-Fluoro-6'-hydroxyacetophenone

2'-Fluoro-6'-hydroxyacetophenone Structure
2'-Fluoro-6'-hydroxyacetophenone structure
CAS No.
93339-98-1
Chemical Name:
2'-Fluoro-6'-hydroxyacetophenone
Synonyms
1-(2-Fluoro-6-hydroxyphenyl)ethan-1-one;2-FLUORO-6-HYDROXYACETOPHENONE;2'-Fluoro-6'-hydroxyacetophenone;1-(2-FLUORO-6-HYDROXYPHENYL)ETHANONE;Ethanone, 1-(2-fluoro-6-hydroxyphenyl)-;1-(2-Fluoro-6-hydroxyphenyl)ethan-1-one, 2-Acetyl-3-fluorophenol
CBNumber:
CB7757152
Molecular Formula:
C8H7FO2
Molecular Weight:
154.14
MDL Number:
MFCD01090995
MOL File:
93339-98-1.mol
Last updated:2026-09-12 18:55:06
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2'-Fluoro-6'-hydroxyacetophenone Properties

Boiling point 224.0±20.0 °C(Predicted)
Density 1.25g/ml
refractive index 1.534
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form liquid
pka 9.17±0.10(Predicted)
color Clear, faint lime

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Hazard Note  Irritant
HS Code  2914500090
NFPA 704
1
2 0

2'-Fluoro-6'-hydroxyacetophenone price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC9896 2'-Fluoro-6'-hydroxyacetophenone ≥95% 93339-98-1 1g $21 2026-06-04 Buy
Apolloscientific PC9896 2'-Fluoro-6'-hydroxyacetophenone ≥95% 93339-98-1 5g $39 2026-06-04 Buy
Apolloscientific PC9896 2'-Fluoro-6'-hydroxyacetophenone ≥95% 93339-98-1 10g $63 2026-06-04 Buy
Activate Scientific AS44435 1-(2-Fluoro-6-hydroxyphenyl)ethanone 98% 93339-98-1 1g $20 2026-06-04 Buy
Activate Scientific AS44435 1-(2-Fluoro-6-hydroxyphenyl)ethanone 98% 93339-98-1 5g $60 2026-06-04 Buy
Product number Packaging Price Buy
PC9896 1g $21 Buy
PC9896 5g $39 Buy
PC9896 10g $63 Buy
AS44435 1g $20 Buy
AS44435 5g $60 Buy

2'-Fluoro-6'-hydroxyacetophenone Chemical Properties,Uses,Production

Preparation

Preparation by reaction of boron tribromide on 2-fluoro-6- methoxyacetophenone (I) in methylene chloride at 65° to 80° (56%). The precursor (I) was obtained by reaction of methyl magnesium iodide on 2-fluoro-6-methoxybenzonitrile in refluxing toluene (quantitative yield).

Synthesis

2'-FLUORO-6'-METHOXYACETOPHENONE

120484-50-6

2'-FLUORO-6'-HYDROXYACETOPHENONE

93339-98-1

General procedure for the synthesis of 2-fluoro-6-hydroxyacetophenone from 2-fluoro-6-methoxyacetophenone: aluminum chloride (14.3 g, 0.107 mol) was added to an ice-cold solution of intermediate 3 (9.0 g, 53.5 mmol) in dichloromethane (70 mL), followed by slow warming of the reaction mixture to room temperature. After the reaction was carried out for 12 h, the reaction was quenched with aqueous 2N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed sequentially with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2-fluoro-6-hydroxyacetophenone as a brown liquid (5.48 g, 66% yield). The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, CDCl3, 400 MHz): δ 12.72 (s, 1H, OH), 7.40 (m, 1H, Ar-H), 6.78 (d, J = 8.5 Hz, 1H, Ar-H), 6.62 (dd, J = 11.3, 8.3 Hz, 1H, Ar-H), 2.69 (d, J = 7.2 Hz, 3H, CH3).

References

[1] Patent: WO2012/151525, 2012, A1. Location in patent: Page/Page column 101
[2] Patent: US2012/289496, 2012, A1. Location in patent: Page/Page column 100
[3] Patent: US5399584, 1995, A
[4] Patent: US2007/14733, 2007, A1. Location in patent: Sheet 14
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 619 - 622

2'-Fluoro-6'-hydroxyacetophenone Preparation Products And Raw materials

Raw materials

2'-Fluoro-6'-methoxyacetophenone Hydrochloric acid Water Aluminum chloride Dichloromethane

Preparation Products

2'-Fluoro-6'-hydroxyacetophenone Suppliers

Global( 119)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Atop-Pharma (Shanghai) Technology Co., Ltd. +86 (21) 5196-9732 China 996 57
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Ark Pharm, Inc. 56
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Atop-Pharma (Shanghai) Technology Co., Ltd. 57
Bide Pharmatech Ltd. 60

View Lastest Price from 2'-Fluoro-6'-hydroxyacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2'-FLUORO-6'-HYDROXYACETOPHENONE pictures 2019-07-12 2'-FLUORO-6'-HYDROXYACETOPHENONE
93339-98-1
 $1.00 1KG 99% 100kg Career Henan Chemical Co

2'-Fluoro-6'-hydroxyacetophenone Spectrum

2'-FLUORO-6'-HYDROXYACETOPHENONE(93339-98-1)1HNMR2'-FLUORO-6'-HYDROXYACETOPHENONE(93339-98-1)19FNMR

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1-(2-FLUORO-6-HYDROXYPHENYL)ETHANONE 2-FLUORO-6-HYDROXYACETOPHENONE 1-(2-Fluoro-6-hydroxyphenyl)ethan-1-one, 2-Acetyl-3-fluorophenol Ethanone, 1-(2-fluoro-6-hydroxyphenyl)- 2'-Fluoro-6'-hydroxyacetophenone 1-(2-Fluoro-6-hydroxyphenyl)ethan-1-one 93339-98-1 9339-98-1 Aromatic Acetophenones & Derivatives (substituted)