3-Fluoro-4-methylbenzoic acid
- CAS No.
- 350-28-7
- Chemical Name:
- 3-Fluoro-4-methylbenzoic acid
- Synonyms
- RARECHEM AL BO 0761;TIMTEC-BB SBB004034;3-FLUORO-P-TOLUIC ACID;3-FLUORO-4-METHYLBENZOIC ACID;3-FFLUORO-4-METHYLBENZOIC ACID;3-Fluoro-4-methylbenzoicacid97%;3-Fluoro-4-methylbenzoicAcid>Benzoic acid, 3-fluoro-4-methyl-;3-Fluoro-4-methylbenzoic acid 97%;3-Fluoro-4-Methylbenzoic acid, 97% 2.5GR
- CBNumber:
- CB7776151
- Molecular Formula:
- C8H7FO2
- Molecular Weight:
- 154.14
- MDL Number:
- MFCD00002490
- MOL File:
- 350-28-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 169-171 °C (lit.) |
|---|---|
| Boiling point | 203.5°C (rough estimate) |
| Density | 1.1850 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 4.03±0.10(Predicted) |
| color | White to Light yellow |
| BRN | 2574141 |
| InChI | 1S/C8H7FO2/c1-5-2-3-6(8(10)11)4-7(5)9/h2-4H,1H3,(H,10,11) |
| InChIKey | XUQCONCMPCVUDM-UHFFFAOYSA-N |
| SMILES | Cc1ccc(cc1F)C(O)=O |
| CAS DataBase Reference | 350-28-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338-P261-P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-24/25-22-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Fluoro-4-methylbenzoic acid price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F10607 | 3-Fluoro-4-methylbenzoic acid 95% | 350-28-7 | 10g | $150 | 2023-01-07 | Buy |
| TCI Chemical | F0552 | 3-Fluoro-4-methylbenzoic Acid >98.0%(GC)(T) | 350-28-7 | 5g | $80 | 2026-04-30 | Buy |
| TCI Chemical | F0552 | 3-Fluoro-4-methylbenzoic Acid >98.0%(GC)(T) | 350-28-7 | 25g | $236 | 2026-04-30 | Buy |
| Biosynth | FF64209 | 3-Fluoro-4-methylbenzoic acid | 350-28-7 | 50g | $150 | 2026-06-04 | Buy |
| Biosynth | FF64209 | 3-Fluoro-4-methylbenzoic acid | 350-28-7 | 100g | $150 | 2026-06-04 | Buy |
3-Fluoro-4-methylbenzoic acid Chemical Properties, Uses, Production
Chemical Properties
white to light yellow crystal powder
Uses
3-Fluoro-4-toluic Acid was used in the synthesis of cyclooxygenase selective and orally active antiinflammatory agents. It was also used to prepare benzamide derivatives as Bcr-Abl kinase inhibitors.
Synthesis
In a Schlenk (50 mL) reaction flask with a carbon dioxide balloon attached at the stub, Cu(OAc)2.H2O (0.0125 mmol), 1,2-bis(diphenylphosphino)benzene (0.018 mmol), and 1,4-dioxane (2.0 mL) were added with stirring, and then the flask was placed at 60 C oil bath for 25 min under carbon dioxide atmosphere, followed by the sequential addition of toluene (8 mL), 3-fluoro-4-methylbromobenzene (1.0 mmol), Pd(OAc)2 (0.03 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethyloxanthene (0.06 mmol), Et3N (2.5 mmol, 2.5 equiva. ), then carbon dioxide was removed and the reaction was carried out at 100 C until the raw material bromobenzene disappeared, cooled to room temperature and sodium hydroxide solution (1M, 10.0 mL) was added, stirred for 10 min and filtered, the solids were washed with water three times, the filtrate was extracted with ethyl acetate (2 10 mL) leaving an aqueous layer, the aqueous layer was adjusted to pH 1-2 with hydrochloric acid solution (1M), ethyl acetate (3 15 mL ) was extracted with ethyl acetate (315 mL), dried with anhydrous sodium sulfate, and the solvent was removed to obtain 3-fluoro-4-methylbenzoic acid in 84% yield.
3-Fluoro-4-methylbenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Latest Price from 3-Fluoro-4-methylbenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 3-Fluoro-4-methylbenzoic acid
350-28-7
|
$200.00 | 1KG | 98% | 100MT/year | Speranza Chemical Co., Ltd. | |
 |
2026-09-02 | 3-Fluoro-4-methylbenzoic acid
350-28-7
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 3-Fluoro-4-methylbenzoic acid
350-28-7
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 3-Fluoro-4-methylbenzoic acid
350-28-7
- $200.00
- 98%
- Speranza Chemical Co., Ltd.
-
- 3-Fluoro-4-methylbenzoic acid
350-28-7
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 3-Fluoro-4-methylbenzoic acid
350-28-7
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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