N-Methyl-N-(2-methylbenzyl)amine
- CAS No.
- 874-33-9
- Chemical Name:
- N-Methyl-N-(2-methylbenzyl)amine
- Synonyms
- N-Methyl-1-(o-tolyl)MethanaMine;N-METHYL-N-(2-METHYL;N,2-Dimethylbenzylamine;methyl(2-methylbenzyl)amine;(2-Methylbenzyl)methylamine;N-Methyl-2-MethylbenzylaMine;2-Methyl-N-methylbenzylamine;Benzenemethanamine, N,2-dimethyl-;N-methyl-1-(2-methylphenyl)methanamine;N-methyl-1-(2-methylphenyl)methanamine 1HCl
- CBNumber:
- CB81490877
- Molecular Formula:
- C9H13N
- Molecular Weight:
- 135.21
- MDL Number:
- MFCD04625428
- MOL File:
- 874-33-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 129 °C |
|---|---|
| Boiling point | 100-102 °C(Press: 11 Torr) |
| Density | 0.917±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 9.76±0.10(Predicted) |
| Appearance | Colorless to light yellow Liquid |
| Water Solubility | Slightly soluble in water. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H314-H318 | |||||||||
| Precautionary statements | P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 2921290090 | |||||||||
| NFPA 704 |
|
N-Methyl-N-(2-methylbenzyl)amine price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS26246-A | N,2-Dimethylbenzylamine 97% | 874-33-9 | 1g | $47 | 2026-06-04 | Buy |
| Activate Scientific | AS26246-A | N,2-Dimethylbenzylamine 97% | 874-33-9 | 5g | $117 | 2026-06-04 | Buy |
| Apolloscientific | OR110980 | N-Methyl-N-(2-Methylbenzyl)amine 97% | 874-33-9 | 5g | $105 | 2026-06-04 | Buy |
| Matrix Scientific | 131238 | N-Methyl-N-(2-methylbenzyl)amine | 874-33-9 | 1.00g | $160 | 2026-05-18 | Buy |
| Synthonix | M50314 | N-Methyl-1-(o-tolyl)methanamine 97% | 874-33-9 | 1g | $29 | 2026-05-06 | Buy |
N-Methyl-N-(2-methylbenzyl)amine Chemical Properties, Uses, Production
Uses
(R)-N-methyl-2-methylbenzylamine is resistant to displacement by the aqueous extractants.
Synthesis
529-20-4
74-89-5
874-33-9
To a methanol (MeOH) solution of 2-methylbenzaldehyde (10.0 g, 83.23 mmol) was slowly added aqueous methylamine (40%, 25.85 g, 332.9 mmol) at 25 °C. The reaction mixture was stirred continuously at 25 °C for 30 min and subsequently cooled to 0 °C. At this temperature, sodium borohydride (NaBH4, 6.30 g, 166.5 mmol) was added in batches. After addition, the reaction mixture was slowly warmed to 25 °C and stirring was continued for 1 hour. After completion of the reaction, the solvent was removed by distillation under reduced pressure. Water and dichloromethane (CH2Cl2) were added to the residue and the organic layer was separated. The organic layer was washed sequentially with saturated sodium bicarbonate (NaHCO3) solution and brine and dried over anhydrous sodium sulfate (Na2SO4). The organic phase was concentrated under reduced pressure to afford the target product N,2-dimethylbenzylamine (10.49 g, 93.2% yield) as an oil of sufficient purity for direct use in subsequent reactions. The product was detected by mass spectrometry (APCI+) showing m/z 136.3 ([M+H]+), and the nuclear magnetic resonance hydrogen spectroscopy (1H-NMR, CDCl3) data were as follows: δ 7.35-7.08 (m, 3H), 3.73 (s, 2H), 2.49 (s, 3H), 2.34 (s, 3H).
References
[1] Patent: US2006/111422, 2006, A1. Location in patent: Page/Page column 53
[2] Journal of the American Chemical Society, 1940, vol. 62, p. 910
[3] Patent: US2006/52378, 2006, A1. Location in patent: Page/Page column 111
[4] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 390 - 401
N-Methyl-N-(2-methylbenzyl)amine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Litong Chemical Technology Co.,Ltd. | 13598610367 0373-7129549 | 2468833170@qq.com | China | 932 | 58 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| Tianjin Olefin Pharmaceutical Co., Ltd. | 18202662021 18522876413 | 2781212171@qq.com | China | 313 | 56 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8135 | 55 |
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