4-Amino-3-chlorobenzoic acid
- CAS No.
- 2486-71-7
- Chemical Name:
- 4-Amino-3-chlorobenzoic acid
- Synonyms
- BUTTPARK 29\06-53;4-Amino-3-chlorobe;RARECHEM AL BO 0579;Curcumin Impurity 6;4-Amino-3-chlorobenz;3-chloro-4-aminobenzoate;4-Carboxy-2-chloroaniline;4-AMINO-3-CHLORBENZOIC ACID;4-Amino-3-chlorobenzioc acid;3-CHLORO-4-AMINOBENZOIC ACID
- CBNumber:
- CB8352668
- Molecular Formula:
- C7H6ClNO2
- Molecular Weight:
- 171.58
- MDL Number:
- MFCD00460423
- MOL File:
- 2486-71-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Amino-3-chlorobenzoic acid 97% | 691445 | 1g | $33.8 |
| 4-Amino-3-chlorobenzoic acid 97% | 691445 | 5g | $82 |
| 4-Amino-3-chlorobenzoic Acid >97.0%(HPLC)(T) | A1971 | 5g | $81 |
| 4-AMINO-3-CHLORO-BENZOIC ACID 97% | 51934 | 5G | $23 |
| 4-AMINO-3-CHLORO-BENZOIC ACID 97% | 51934 | 10G | $44 |
| More product size | |||
| Melting point | 228 °C |
|---|---|
| Boiling point | 341.2±27.0 °C(Predicted) |
| Density | 1.476±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 4.49±0.10(Predicted) |
| color | White to Orange to Green |
| Major Application | peptide synthesis |
| InChI | 1S/C7H6ClNO2/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3H,9H2,(H,10,11) |
| InChIKey | YIYBPEDZAUFQLO-UHFFFAOYSA-N |
| SMILES | Nc1ccc(cc1Cl)C(O)=O |
| CAS DataBase Reference | 2486-71-7(CAS DataBase Reference) |
| FDA UNII | GBC9H9RW4T |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29224999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Amino-3-chlorobenzoic acid price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 691445 | 4-Amino-3-chlorobenzoic acid 97% | 2486-71-7 | 1g | $33.8 | 2023-06-20 | Buy |
| Sigma-Aldrich | 691445 | 4-Amino-3-chlorobenzoic acid 97% | 2486-71-7 | 5g | $82 | 2023-06-20 | Buy |
| TCI Chemical | A1971 | 4-Amino-3-chlorobenzoic Acid >97.0%(HPLC)(T) | 2486-71-7 | 5g | $81 | 2026-04-30 | Buy |
| AstaTech | 51934 | 4-AMINO-3-CHLORO-BENZOIC ACID 97% | 2486-71-7 | 5G | $23 | 2026-04-30 | Buy |
| AstaTech | 51934 | 4-AMINO-3-CHLORO-BENZOIC ACID 97% | 2486-71-7 | 10G | $44 | 2026-04-30 | Buy |
4-Amino-3-chlorobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
White powder
Uses
4-Amino-3-chlorobenzoic Acid is a reagent used in the synthesis of orally bioavailable 1H-Pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase MPS1which is overexpressed in cancer cell lines.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
84228-44-4
2486-71-7
General procedure for the synthesis of 3-chloro-4-aminobenzoic acid from methyl 4-amino-3-chlorobenzoate: 1. Saponification reaction: 4-amino-3-chlorobenzoic acid methyl ester (21.6 mmol) was dissolved in ethanol (25 mL) and 1M NaOH aqueous solution (25 mL), and heated to reflux for 2 hours. 2. Post-treatment: after completion of the reaction, the organic solvent was removed by evaporation and the pH of the reaction solution was adjusted to 4 with acid. 3. Isolation and purification: The precipitate was collected by filtration, washed with water and subsequently dried under vacuum to obtain the target product 3-chloro-4-aminobenzoic acid. Yield: 92%. 1H NMR (D6-DMSO) δ: 6.15 (s, 2H), 6.79 (d, 1H), 7.59 (dd, 1H), 7.71 (d, 1H), 12.37 (br s, 1H).
References
[1] Patent: WO2005/39572, 2005, A1. Location in patent: Page/Page column 25
[2] Patent: WO2006/114093, 2006, A1. Location in patent: Page/Page column 37
4-Amino-3-chlorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2971 | 58 |
| Changzhou Carman Chemical Co., Ltd. | 15061933924 | CHINA | 513 | 58 | |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10817 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21135 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
View Lastest Price from 4-Amino-3-chlorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | 4-Amino-3-chlorobenzoic acid
2486-71-7
|
$7.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
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- 4-Amino-3-chlorobenzoic acid
2486-71-7
- $7.00
- 99%
- Career Henan Chemical Co
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