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Methyl 3-amino-4-methylbenzoate

Methyl 3-amino-4-methylbenzoate Structure
Methyl 3-amino-4-methylbenzoate structure
CAS No.
18595-18-1
Chemical Name:
Methyl 3-amino-4-methylbenzoate
Synonyms
NILOTINIB RELATED COMPOUND B;3-AMINO-4-METHYLBENZOIC ACID METHYL ESTER;AKOS BB-3092;3-Amino-p-toluic;Compound Fr13901;Methyl 3-amino-4-met;Nilotinib Impurity 25;LABOTEST-BB LT00848257;Nilotinib EP Impurity B;3-Amino-4-Methylbenzoate
CBNumber:
CB4316035
Molecular Formula:
C9H11NO2
Molecular Weight:
165.19
MDL Number:
MFCD00025206
MOL File:
18595-18-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-25 18:36:05
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Methyl 3-amino-4-methylbenzoate Properties

Melting point 113-117 °C(lit.)
Boiling point 296.3±20.0 °C(Predicted)
Density 1.132±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka 3.31±0.10(Predicted)
form Crystalline Powder
color White to cream
BRN 2088611
InChI InChI=1S/C9H11NO2/c1-6-3-4-7(5-8(6)10)9(11)12-2/h3-5H,10H2,1-2H3
InChIKey YEPWCJHMSVABPQ-UHFFFAOYSA-N
SMILES C(OC)(=O)C1=CC=C(C)C(N)=C1
LogP 1.7 at 22℃ and pH7
CAS DataBase Reference 18595-18-1(CAS DataBase Reference)
FDA UNII CUK1YN8P3C
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280-P302+P352-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37
WGK Germany  3
Hazard Note  Irritant
HS Code  29224999
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
1
2 0

Methyl 3-amino-4-methylbenzoate price More Price(84)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0002111 Nilotinib impurity B European Pharmacopoeia (EP) Reference Standard 18595-18-1 25 mg $206 2026-04-30 Buy
Sigma-Aldrich Y0002111 Nilotinib impurity B European Pharmacopoeia (EP) Reference Standard 18595-18-1 Y0002111 $186 2023-01-07 Buy
TCI Chemical A1432 Methyl 3-Amino-4-methylbenzoate >98.0%(GC) 18595-18-1 25g $24 2026-04-30 Buy
Usbiological 261200 3-Amino-4-methylbenzoic acid methyl ester Asreported 18595-18-1 25g $333 2026-06-03 Buy
Usbiological 261200 3-Amino-4-methylbenzoic acid methyl ester Asreported 18595-18-1 50g $478 2026-06-03 Buy
Product number Packaging Price Buy
Y0002111 25 mg $206 Buy
Y0002111 Y0002111 $186 Buy
A1432 25g $24 Buy
261200 25g $333 Buy
261200 50g $478 Buy

Methyl 3-amino-4-methylbenzoate Chemical Properties, Uses, Production

Description

Methyl 3-amino-4-methylbenzoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Chemical Properties

Beige powder

Uses

Methyl 3-Amino-4-methylbenzoate is used as a reagent in the synthesis of perfluoroalkylated indoles which are very useful in drug development. It was also used in the preparation of 4-(pyrimidin-2-ylamino) benzamide derivatives which are designed as inhibitors of hedgehog signalling pathway (target of cancer treatment).

Application

Methyl 3-amino-4-methylbenzoate can be used for:
To prepare the methyl 4-methyl-3-((4-(proparg-1-yloxy)benzyl)amino)benzoate, 4-proparg-1-yloxybenzaldehyde (16) and methyl 3-amino-4-methylbenzoate were reacted according to the method IA.
Synthesis of Methyl 4-methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzoate
Synthesis of 4-Methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzamide
Synthesis of methyl 3-(4-hydroxy-6-methyl-2-oxopyridin-1 (2H)-yl)-4-methylbenzoate
Synthesis of methyl 3-(4-hydroxy-6-methyl-2-oxopyridin-1 (2H)-yl)-4-methylbenzoate
Synthesis of (5-Carbomethoxy-2-methylphenyl)(4-hydroxypheny)diazene: To a solution of 6N HC1 (6 mL) was added methyl 3-amino-4-methylbenzoate (1.62 g, 10.0 mmol). The solution was cooled in an ice-bath, and was diazotized by adding sodium nitrite (0.9 g, 12.0 mmol). To a cold solution of phenol in 21% aqueous NaOH solution (6 mL) was added diazotized solution slowly. After 20 min, the solution was acidfied by adding 4 N aqueous HC1 and was poured into the cold water, filtered, and washed with water. Recrystallization from ethanol gave the product (2.0 g, 74%) as red crystals, mp 181.3-182.2 °C.

Preparation

Synthesis of Methyl 3-amino-4-methylbenzoate: Nitro ester Methyl 4-methyl-3-nitrobenzoate (80 g, 0.410 mol) was subjected to hydrogenation in a Parr shaker in MeOH using Raney Ni as the catalyst (5 g, 20 mol %) at 50 psi for 8 hours. The catalyst was filtered off, washed thoroughly with MeOH and the combined filtrates concentrated under reduced pressure to furnish a yellow solid (65.0 g). Yield : 96% Mp : 114-5°C (lit.14 Mp 116°C)

Definition

ChEBI: Methyl 3-amino-4-methylbenzoate is a benzoate ester.

Synthesis

Methanol

67-56-1

3-Amino-4-methylbenzoic acid

2458-12-0

Methyl 3-amino-4-methylbenzoate

18595-18-1

3-Amino-4-methylbenzoic acid (60.5 g, 0.40 mol) was dissolved in anhydrous methanol (1.5 L), stirred and cooled to 5°C. The reaction was completed by the addition of thionyl chloride (103.6 g, 0.87 mol). Thionyl chloride (103.6 g, 0.87 mol) was added slowly dropwise, and after completion of the dropwise addition, the reaction was stirred and refluxed for 6 hours. After completion of the reaction, it was cooled to room temperature and the reaction solution was concentrated under reduced pressure. The residue was diluted with ice water (1.2 L) and neutralized by adding 5% NaHCO3 solution to pH 7.5. The aqueous layer was extracted with ethyl acetate (3 × 600 mL), and the organic layers (2 × 500 mL) were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure to give methyl 3-amino-4-methylbenzoate (62.7 g, 94.9% yield) as a white solid.

References

[1] Patent: CN105693520, 2016, A. Location in patent: Paragraph 0184; 0185; 0186; 0187; 0188; 0189
[2] Patent: EP3067351, 2016, A1. Location in patent: Paragraph 0083; 0084
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 14, p. 6724 - 6731
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 6, p. 2423 - 2435

Methyl 3-amino-4-methylbenzoate synthesis

67-56-1
2458-12-0
18595-18-1
Synthesis of Methyl 3-amino-4-methylbenzoate from Methanol and 3-Amino-4-methylbenzoic acid

Methyl 3-amino-4-methylbenzoate Preparation Products And Raw materials

Raw materials

3-Amino-4-methylbenzoic acid Methyl 3-bromo-4-methylbenzoate Methanol 4-Methyl-3-nitrobenzoic acid 4-Methyl-3-nitrobenzoic acid methyl ester
Methyl 4-methylbenzoate

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Preparation Products

3-Acetamido-4-methylbenzoic acid Methyl 1H-indazole-6-carboxylate 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid Methyl 3-cyano-4-Methylbenzoate 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester
5-aMino-2-broMo-4-Methylbenzoic acid Methyl ester 1H-Indazole-6-carboxylic acid, 5-broMo-, Methyl ester

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Methyl 3-amino-4-methylbenzoate Suppliers

Global Suppliers ( 423)
Supplier Tel Email Country ProdList Advantage
Wuhan Beileye Biomedical Technology Co., Ltd. 18086118078 2696158611@qq.com China 4271 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Supplier Advantage
Wuhan Beileye Biomedical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56
Energy Chemical 61
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
JinYan Chemicals(ShangHai) Co.,Ltd. 60

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View Latest Price from Methyl 3-amino-4-methylbenzoate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl 3-amino-4-methylbenzoate pictures 2026-09-17 Methyl 3-amino-4-methylbenzoate
18595-18-1
 $106.05 25Kg/Drum 99.00%HPLC 8tons/month Asia Chem I and E (Jiangsu) Co Ltd
Methyl 3-amino-4-methylbenzoate pictures 2026-09-17 Methyl 3-amino-4-methylbenzoate
18595-18-1
 1KG 98%min 10 tons WUHAN FORTUNA CHEMICAL CO., LTD
Methyl 3-amino-4-methylbenzoate pictures 2026-06-30 Methyl 3-amino-4-methylbenzoate
18595-18-1
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

Methyl 3-amino-4-methylbenzoate Spectrum

Methyl 3-amino-4-methylbenzoate(18595-18-1)MSMethyl 3-amino-4-methylbenzoate(18595-18-1)1HNMRMethyl 3-amino-4-methylbenzoate(18595-18-1)13CNMRMethyl 3-amino-4-methylbenzoate(18595-18-1)IR1Methyl 3-amino-4-methylbenzoate(18595-18-1)IR2

18595-18-1 (Methyl 3-amino-4-methylbenzoate) Related Search:

Methyl 2-iodobenzoate 4-Dimethylaminobenzoic acid 6-Aminocaproic acid 4-Aminobenzoic acid Methylparaben
Kresoxim-methyl Methyl benzoate 2-Amino-4-methylbenzoic acid Methyl acetate Bensulfuron methyl
Methyl acrylate 3-Amino-4-methylbenzoic acid 4-Methyl-3-nitrobenzoic acid Thiophanate-methyl Glycine
Metsulfuron methyl Methyl METHYL 2-AMINO-3-METHYLBENZOATE

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METHYL 3-AMINO-4-METHYLBENZOATE METHYL 3-AMINO-P-TOLUATE LABOTEST-BB LT00848257 3-amino-2,4-dimethylbenzoate Nilotinib Impurity 25 Nilotinib EP Impurity B 3-Amino-p-Toluic Acid Methyl Ester 3-Amino-4-Methyl Benzoic Acid Methyl Ester 3-Amino-4-Methylbenzoate 3-Amino-p-toluic Methyl 3-amino-4-methylbenzoate 98% Methyl 3-Amion-4-Methylbenzoate AKOS BB-3092 3-AMINO-P-TOLUIC ACID METHYL ESTER Methyl4-Methyl-3-Aminobenzoate Methyl 3-amino-4-met 3-Amino-4-methylbenzoic Acid Methyl Ester Methyl 3-Amino-p-toluate 3-Amino-p-toluic Acid Methyl Ester Methyle3-amino-4-methylbenzoate 5-(Methoxycarbonyl)-2-methylaniline, 2-Amino-4-(methoxycarbonyl)toluene, 5-(Methoxycarbonyl)-o-toluidine Benzoic acid, 3-aMino-4-Methyl-, Methyl ester Methyl-3-amino-4-methylbenozate Methyl 3-Amino-4-methylbenzoate > Methyl 3-amino-4-methylbenzoate 18595-18-1 Nilotinib Hydrochloride Monohydrate EP Impurity B Nilotinib USP Related Compound B Benzoic acid, 3-amino-4-methyl-, methyl ester (9CI, ACI) 3-amino-4-methyl-Benzoic acid methyl ester (9CI ACI) Compound Fr13901 Nilotinib Impurity 17(Nilotinib EP Impurity B) Nilotinib EP Impurity B (Nilotinib USP Related Compound B) 3-AMINO-4-METHYLBENZOIC ACID METHYL ESTER NILOTINIB RELATED COMPOUND B 18595-18-1 18585-18-1 Esters Organic Building Blocks Building Blocks Carbonyl Compounds C8 to C9 Building Blocks C8 to C9 Carbonyl Compounds Chemical Synthesis Organic Building Blocks Aromatic Esters Esters Phenyls & Phenyl-Het FINE Chemical & INTERMEDIATES Acids and Derivatives Amines and Anilines bc0001