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(4-Bromo-3-fluorophenyl)methanol

(4-Bromo-3-fluorophenyl)methanol Structure
(4-Bromo-3-fluorophenyl)methanol structure
CAS No.
222978-01-0
Chemical Name:
(4-Bromo-3-fluorophenyl)methanol
Synonyms
3-Fluoro-4-Bromobenzyl alcohol;4-Bromo-3-fluorobenzenemethanol;(4-Bromo-3-fluorophenyl)methanol;4-Bromo-3-fluorobenzylalcohol,96%;BenzeneMethanol, 4-broMo-3-fluoro-;(4-BROMO-3-FLUOROPHENYL)METHANOL ISO 9001：2015 REACH
CBNumber:
CB8750392
Molecular Formula:
C7H6BrFO
Molecular Weight:
205.02
MDL Number:
MFCD08236860
MOL File:
222978-01-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:52
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(4-Bromo-3-fluorophenyl)methanol Properties

Melting point 44.0 to 48.0 °C
Boiling point 260℃
Density 1.658
Flash point 111℃
storage temp. Sealed in dry,Room Temperature
solubility soluble in Methanol
form powder to crystal
pka 13.70±0.10(Predicted)
color White to Almost white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
HS Code  2906290090
NFPA 704
1
2 0

(4-Bromo-3-fluorophenyl)methanol price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B4956 4-Bromo-3-fluorobenzyl Alcohol >98.0%(GC) 222978-01-0 1g $81 2026-04-30 Buy
Biosynth FB67504 4-Bromo-3-fluorobenzyl alcohol 222978-01-0 1g $150 2026-06-04 Buy
Biosynth FB67504 4-Bromo-3-fluorobenzyl alcohol 222978-01-0 2g $150 2026-06-04 Buy
Biosynth FB67504 4-Bromo-3-fluorobenzyl alcohol 222978-01-0 5g $192.15 2026-06-04 Buy
Biosynth FB67504 4-Bromo-3-fluorobenzyl alcohol 222978-01-0 10g $288.3 2026-06-04 Buy
Product number Packaging Price Buy
B4956 1g $81 Buy
FB67504 1g $150 Buy
FB67504 2g $150 Buy
FB67504 5g $192.15 Buy
FB67504 10g $288.3 Buy

(4-Bromo-3-fluorophenyl)methanol Chemical Properties, Uses, Production

Uses

(4-Bromo-3-fluorophenyl)methanol is used to prepare triazolopyridyl compounds, which can be used as a prodrug of RIPK1 inhibitors.

Synthesis

4-Bromo-3-fluorobenzoic acid

153556-42-4

(4-BROMO-3-FLUOROPHENYL)METHANOL

222978-01-0

GENERAL METHODS: Borane-tetrahydrofuran complex (BH3-THF, 89 mL, 89.49 mmol) was slowly added dropwise to a stirred solution of 3-fluoro-4-bromobenzoic acid (9.8 g, 44.75 mmol) in tetrahydrofuran (THF, 200 mL) at 25 °C. The dropwise addition was controlled to be completed in 10 min, and the reaction was carried out under nitrogen protection. The reaction mixture was stirred continuously at room temperature for 2 days. Upon completion of the reaction, the reaction was carefully quenched with 2 M sodium carbonate solution (Na2CO3, 200 mL) and subsequently extracted with ether (Et2O, 2 x 500 mL). The organic phases were combined, washed with saturated brine (400 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give a pale yellow oil. The crude product was purified by fast silica gel column chromatography, the eluent was a mixture of heptane and ethyl acetate (EtOAc) with a gradient elution ratio of 0 to 70% ethyl acetate. The purified fraction was collected and concentrated to dryness under reduced pressure to give 4-bromo-3-fluorobenzyl alcohol (8.65 g, 94% yield) as a white solid.

References

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 21, p. 9096 - 9104
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 14, p. 2973 - 2984
[3] Synlett, 2014, vol. 25, # 1, p. 123 - 127
[4] European Journal of Medicinal Chemistry, 2018, vol. 150, p. 506 - 524
[5] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 10, p. 1257 - 1260

(4-Bromo-3-fluorophenyl)methanol Preparation Products And Raw materials

Raw materials

Methyl 4-bromo-3-fluorobenzoate 98 4-Bromo-3-fluorobenzoic acid 4-Bromo-3-fluorobenzaldehyde Borane THF Tetrahydrofuran

Preparation Products

4-(Bromomethyl)-2-fluorobenzonitrile

(4-Bromo-3-fluorophenyl)methanol Suppliers

Global Suppliers ( 138)
Supplier Tel Email Country ProdList Advantage
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Supplier Advantage
Alfa Aesar 84
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Adamas Reagent, Ltd. 59
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
T&W GROUP 58

View Latest Price from (4-Bromo-3-fluorophenyl)methanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(4-Bromo-3-fluorophenyl)methanol pictures 2022-01-27 (4-Bromo-3-fluorophenyl)methanol
222978-01-0
 1KG 99.4% 100 tons Honest Joy Holdings Limited
(4-BROMO-3-FLUOROPHENYL)METHANOL pictures 2019-12-23 (4-BROMO-3-FLUOROPHENYL)METHANOL
222978-01-0
 $1.00 1KG 99% 200kg Career Henan Chemical Co

(4-Bromo-3-fluorophenyl)methanol Spectrum

(4-BROMO-3-FLUOROPHENYL)METHANOL(222978-01-0)1HNMR

222978-01-0 ((4-Bromo-3-fluorophenyl)methanol) Related Search:

Methyl 4-bromo-3-fluorobenzoate 98 4-Bromo-2,3,5,6-tetrafluorobenzoic acid 4-Bromo-3-fluorobenzoic acid 4-Bromo-2,3,5,6-tetrafluorobenzylalcohol (4-Bromo-3-fluorophenyl)methanol
4-bromo-2,5-difluorobenzoic acid 4-Bromo-2,3-difluorobenzoic acid 4-Bromo-2-chloro-5-fluorobenzoic acid tert-Butyl 4-bromo-3-fluorobenzoate 4-Bromo-2,3,6-trifluorobenzyl alcohol
4-Bromo-3-fluorobenzoic acid ethyl ester 4-Bromo-5-fluoro-2-nitrobenzoic acid 2-Amino-4-bromo-5-fluorobenzoic acid ethyl 4-bromo-2,3,5,6-tetrafluorobenzimidate RARECHEM AL BP 1308
RARECHEM AL BI 1308 RARECHEM AL BF 1308 tert-Butyl 4-bromo-2,3,5,6-tetrafluorobenzoate

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4-Bromo-3-fluorobenzenemethanol BenzeneMethanol, 4-broMo-3-fluoro- 4-Bromo-3-fluorobenzylalcohol,96% (4-BROMO-3-FLUOROPHENYL)METHANOL ISO 9001：2015 REACH 3-Fluoro-4-Bromobenzyl alcohol (4-Bromo-3-fluorophenyl)methanol 222978-01-0