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H-His(Trt)-OH

H-His(Trt)-OH Structure
H-His(Trt)-OH structure
CAS No.
35146-32-8
Chemical Name:
H-His(Trt)-OH
Synonyms
His(Trt);L-His(Trt)-OH;H-L-HIS(TRT)-OH;L-His(Trt);H-HIS(TRT)-OH;L-His(Trt)·H2O;H-HIS(T-TRT)-OH;H-HIS(1-TRT)-OH;H-His(tau-Trt)-OH;RARECHEM AL BE 1480
CBNumber:
CB9185713
Molecular Formula:
C25H23N3O2
Molecular Weight:
397.47
MDL Number:
MFCD00153444
MOL File:
35146-32-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:25:20
Product description Number Pack Size Price
Nim-Trityl-histidine Asreported 285606 2g $333
Nim-Trityl-histidine Asreported 285606 5g $470
Nim-Trityl-histidine Asreported 285606 10g $632
Nim-Trityl-histidine Asreported 285606 25g $848
Nim-Trityl-histidine 98+% (HPLC) ≥98%(HPLC) 240956 1g $170
More product size
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H-His(Trt)-OH Properties

Melting point 210℃
Boiling point 584.8±50.0 °C(Predicted)
Density 1.19±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
pka 1.78±0.10(Predicted)
form Solid
color White to off-white
InChI InChI=1S/C25H23N3O2/c26-23(24(29)30)16-22-17-28(18-27-22)25(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-15,17-18,23H,16,26H2,(H,29,30)/t23-/m0/s1
InChIKey BSZQZNOAYQCQFZ-QHCPKHFHSA-N
SMILES C(O)(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)N

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3
F  10
NFPA 704
1
0 0

H-His(Trt)-OH price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 285606 Nim-Trityl-histidine Asreported 35146-32-8 2g $333 2026-06-03 Buy
Usbiological 285606 Nim-Trityl-histidine Asreported 35146-32-8 5g $470 2026-06-03 Buy
Usbiological 285606 Nim-Trityl-histidine Asreported 35146-32-8 10g $632 2026-06-03 Buy
Usbiological 285606 Nim-Trityl-histidine Asreported 35146-32-8 25g $848 2026-06-03 Buy
Usbiological 240956 Nim-Trityl-histidine 98+% (HPLC) ≥98%(HPLC) 1g $170 2026-06-03 Buy
Product number Packaging Price Buy
285606 2g $333 Buy
285606 5g $470 Buy
285606 10g $632 Buy
285606 25g $848 Buy
240956 1g $170 Buy

H-His(Trt)-OH Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

1-(Triphenylmethyl)-L-histidine is a reactant in the synthesis of falcitidin acyl tetrapeptides as antimalarial agent.

Definition

H-His(Trt)-OH, also known as 1-(Triphenylmethyl)-L-histidine, is a histidine derivative. It can be obtained by removing fmoc group protection from Fmoc-His(Trt)-OH. L-histidine (HIS) is an essential amino acid with unique roles in proton buffering, metal ion chelation, scavenging of reactive oxygen and nitrogen species, erythropoiesis, and the histaminergic system.

Preparation

The amino acid N(im)-trityl-D-histidine was dissolved in dichloromethane, followed by the addition of triethylamine and trimethylsilyl chloride (3.5 equivalents). After 2 hours of gentle reflux, the mixture was ready to be used for in situ coupling to the anhydride of the carboxylic acid. Thus, isovaleric acid was separately dissolved in THF and maintained at -20 ℃ using an ice-salt bath. N-methyl morpholine (1.2 equivalents) was added, followed by the addition of ethyl chloroformate (1.0 equivalent). After 15-20 minutes at -20 ℃, the bis-TMS amino acid reaction mixture was added directly to the anhydride solution and left stirring at room temperature overnight. After 8 hours, the reaction mixture was concentrated in vacuo. Finally, H-His(Trt)-OH was obtained after purification.H-HIS(TRT)-OH

Synthesis

Fmoc-His(Trt)-OH

109425-51-6

H-His(Trt)-OH

35146-32-8

General procedure for the synthesis of N'-(triphenylmethyl)-L-histidine from N-Fmoc-N'-trityl-L-histidine: Fmoc-His(Trt)-OH (100 g, 0.161 mol, 1 eq.) was dissolved in THF (2000 mL) and piperidine (140 g, 1.614 mol, 10 eq.) was added under stirring conditions. The reaction mixture was stirred for 2 hours using a mechanical stirrer. The progress of the reaction was monitored by thin layer chromatography (TLC) to confirm the complete removal of the Fmoc protecting group. Subsequently, water (~4 L) was added to the reaction system and stirring was continued for 30 min. The precipitate was collected by filtration. The filtrate was concentrated to remove THF completely. pH of the solution was adjusted to 2.5 with dilute hydrochloric acid and the mixture was stirred overnight. Filtration yielded 53 g of colorless crystals (83% yield) and the product was dried in air overnight.

References

[1] Patent: WO2012/136604, 2012, A1. Location in patent: Page/Page column 42-43
[2] Tetrahedron Letters, 2014, vol. 55, # 11, p. 1949 - 1951

H-His(Trt)-OH Preparation Products And Raw materials

Raw materials

Fmoc-His(Trt)-OH Tetrahydrofuran Piperidine

Preparation Products

Fmoc-His(Trt)-OH

H-His(Trt)-OH Suppliers

Global( 207)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co.,Ltd. 		+86-0512-68071238 +86-13771819922 june@highfine.com China 489 58
Sichuan HongRi Pharma-Tech Co.,Ltd
+8618382028708 ni@enlaibio.com China 1103 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14014 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
GenicBio Limited 		+86-21-37621270 service@genicbio.com CHINA 991 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Sichuan Jiaying Lai Technology Co.,LTD 		18716376478 ycling@enlaibio.com CHINA 302 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8828 58
Supplier Advantage
Suzhou Highfine Biotech Co.,Ltd. 		58
Sichuan HongRi Pharma-Tech Co.,Ltd
58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
GenicBio Limited 		58
career henan chemical co 		58
Sichuan Jiaying Lai Technology Co.,LTD 		58
Alchem Pharmtech,Inc. 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58

View Lastest Price from H-His(Trt)-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
H-L-His(trt)-OH pictures 2026-06-24 H-L-His(trt)-OH
35146-32-8
 1kg 98%;99% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
H-His(trt)-OH pictures 2020-01-06 H-His(trt)-OH
35146-32-8
 $1.00 1g 98% 100KG Sichuan Jiaying Lai Technology Co.,LTD
H-HIS(TRT)-OH pictures 2019-07-06 H-HIS(TRT)-OH
35146-32-8
 $1.00 1KG 98% 1kg,5kg,100kg Career Henan Chemical Co
  • H-His(trt)-OH pictures
  • H-His(trt)-OH
    35146-32-8
  • $1.00
  • 98%
  • Sichuan Jiaying Lai Technology Co.,LTD

H-His(Trt)-OH Spectrum

H-His(Trt)-OH(35146-32-8)1HNMR

35146-32-8(H-His(Trt)-OH)Related Search:

Methyl L-histidinate dihydrochloride H-HIS(BZL)-OH 3-METHYL-L-HISTIDINE H-His(Trt)-OMe · HCl 3,5-DIIODO-D-TYROSINE HYDROCHLORIDE
Fmoc-His(Trt)-OH N-Fmoc-N'-Trityl-L-histidine pentafluorophenyl ester H-His(Trt)-OH Boc-His(Trt)-OH TRT-OH
N-Boc-S-Trityl-L-cysteine N-Boc-N'-trityl-L-glutamine N-FMOC-GLY(TRT)-OH FMOC-D-PEN(TRT)-OH Z-ASN(TRT)-OH
Fmoc-Asn(Trt)-OH H-GLN(TRT)-OH Z-GLN(TRT)-OH

1of4

N-τ-Trityl-L-histidine 1-(Triphenylmethyl)-L-histidine L-His(Trt)·H2O Nim-Trityl-histidine≥ 98% (HPLC) (2S)-2-amino-3-(1-tritylimidazol-4-yl)propanoicacid 1-Trityl-L-histidine, 98% HISTIDINE(1-TRT)-OH H-HIS(1-TRT)-OH H-HIS(T-TRT)-OH H-HIS(TRT)-OH RARECHEM AL BE 1480 N-IM-TRITYL-HISTIDINE N-IM-TRITYL-L-HISTIDINE N-TAU-TRITYL-L-HISTIDINE N-TRITYL-L-HISTIDINE H-His(tau-Trt)-OH (2S)-2-amino-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid (2S)-2-amino-3-[1-(triphenylmethyl)-4-imidazolyl]propanoic acid L-His(Trt) (2S)-2-ammonio-3-(1-trityl-1H-imidazol-4-yl)propanoate (S)-2-Amino-3-(1-trityl-1H-imidazol-4-yl)propanoicacid L-Histidine, 1-(triphenylmethyl)- (2S)-2-amino-3-(1-tritylimidazol-4-yl)propanoicaci H-HIS(TRT)-OH USP/EP/BP 1-Trityl-L-histidine, 98% N'-(tribenzyl)-L-histidineaminoacid H-L-HIS(TRT)-OH His(Trt) L-His(Trt)-OH 35146-32-8 C25H23N3O2 Histidine Peptide Synthesis Specialty Synthesis Amino Acid Derivatives Histidine [His, H] Amino Acids and Derivatives Amino Acid Derivatives Histidine Peptide Synthesis