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Fmoc-His(Trt)-OH

Fmoc-His(Trt)-OH Structure
Fmoc-His(Trt)-OH structure
CAS No.
109425-51-6
Chemical Name:
Fmoc-His(Trt)-OH
Synonyms
FMOC-HIS(TRT)-OH;FMOC-HIS(TRT);FMOC-L-HIS(TRT)-OH;Fomc-His(Trt)-OH;Fmoc-His(Trt)-0H;FMOC-HIS(TRITYL)-OH;N-FMOC-N-TRITYL-L-HISTIDINE;N-Fmoc-N'-trityl-L-histidine;Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-τ-(triphenylmethyl)-L-histidine;(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid
CBNumber:
CB8444769
Molecular Formula:
C40H33N3O4
Molecular Weight:
619.71
MDL Number:
MFCD00043332
MOL File:
109425-51-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:24:11
Product description Number Pack Size Price
Fmoc-His(Trt)-OH Novabiochem? 8.52032 25g $94.8
Fmoc-His(Trt)-OH Novabiochem? 8.52032 100g $232
Fmoc-His(Trt)-OH Novabiochem? 8.52032 250g $501
Fmoc-His(Trt)-OH Novabiochem® 8.52032 500 g $919
Fmoc-His(Trt)-OH Novabiochem? 8.52032 1kg $1650
More product size
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Fmoc-His(Trt)-OH Properties

Melting point 150-155 °C(lit.)
alpha +86.0 °(D/25)(c=5%inCHCl3)
Boiling point 811.7±65.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
refractive index 97 ° (C=5, CHCl3)
storage temp. 2-8°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka 3.06±0.10(Predicted)
form Powder
color White to off-white
optical activity [α]/D 87±5°, c = 1 in chloroform
Water Solubility Slightly soluble in water.
Sensitive Moisture Sensitive
BRN 5204720
Major Application peptide synthesis
InChIKey XXMYDXUIZKNHDT-QNGWXLTQSA-N
SMILES OC(=O)[C@H](Cc1cn(cn1)C(c2ccccc2)(c3ccccc3)c4ccccc4)NC(=O)OCC5c6ccccc6-c7ccccc57
CAS DataBase Reference 109425-51-6(CAS DataBase Reference)
UNSPSC Code 12352209
NACRES NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P302+P352-P362+P364
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-24/25
WGK Germany  3
F  10-21
HS Code  2933 29 90
Storage Class 11 - Combustible Solids
REACH Registrations Active
NFPA 704
1
2 0

Fmoc-His(Trt)-OH price More Price(124)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.52032 Fmoc-His(Trt)-OH Novabiochem? 109425-51-6 25g $94.8 2026-04-30 Buy
Sigma-Aldrich 8.52032 Fmoc-His(Trt)-OH Novabiochem? 109425-51-6 100g $232 2026-04-30 Buy
Sigma-Aldrich 8.52032 Fmoc-His(Trt)-OH Novabiochem? 109425-51-6 250g $501 2026-04-30 Buy
Sigma-Aldrich 8.52032 Fmoc-His(Trt)-OH Novabiochem® 109425-51-6 500 g $919 2026-04-30 Buy
Sigma-Aldrich 8.52032 Fmoc-His(Trt)-OH Novabiochem? 109425-51-6 1kg $1650 2026-04-30 Buy
Product number Packaging Price Buy
8.52032 25g $94.8 Buy
8.52032 100g $232 Buy
8.52032 250g $501 Buy
8.52032 500 g $919 Buy
8.52032 1kg $1650 Buy

Fmoc-His(Trt)-OH Chemical Properties,Uses,Production

Chemical Properties

White to off-white solid powder, soluble in water but poorly soluble in ethanol and insoluble in ether. Its structure contains a unique imidazole unit. The imidazole group can form a coordination compound with Fe2+ or other metal ions to promote the absorption of iron, so it can be used to prevent and treat anemia.

Uses

Fmoc-His(Trt)-OH is used in the synthesis and application of Fmoc-His(3-Bum)-OH.

General Description

Fmoc-His(Trt)-OH has fmoc group to protect -αNH2, it can be used as a building block in solid-phase peptide synthesis (SPPS).

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

In a dry reaction flask, N-deprotected amino acids were dissolved in 0.15 M sodium carbonate (2~3 equiv.), and then an acetone solution ( 0.1 M) of 9-fluorenylmethyl-N-succinimidyl carbonate (1~1.2 equiv.) was added to the above reaction mixture. Water was added to the reaction system to adjust the pH of the reaction system to 9~10. The resulting reaction mixture was stirred at room temperature for 4 h. At the end of the reaction, the resulting reaction mixture was concentrated at 30 C under reduced pressure to remove the acetone, and the resulting residue was diluted with H2O and the pH of the solution was adjusted to 9~10 with sodium carbonate 0.6 M. The resultant solution was extracted twice with ether. The pH of the aqueous phase was adjusted to 4-5 by slowly adding 10 % citric acid to the resulting organic solution, the organic layer was separated and dried with anhydrous sodium sulfate, the desiccant was removed by filtration and the resulting filtrate was concentrated under vacuum, and the resulting crude product was purified by silica gel column chromatography to obtain the molecules of N-Fmoc-N'-trityl-L-histidine.

Fmoc-His(Trt)-OH synthesis

28920-43-6
35146-32-8
109425-51-6
Synthesis of Fmoc-His(Trt)-OH from 9-Fluorenylmethyl chloroformate and H-His(Trt)-OH

Fmoc-His(Trt)-OH Preparation Products And Raw materials

Raw materials

H-His(Trt)-OH 9-Fluorenylmethyl chloroformate

Preparation Products

ANGIOTENSIN I, HUMAN ANGIOTENSIN II, HUMAN Copper Peptide

Fmoc-His(Trt)-OH Suppliers

Global( 550)Suppliers
Supplier Tel Email Country ProdList Advantage
Suzhou Highfine Biotech Co.,Ltd. 		+86-0512-68071238 +86-13771819922 june@highfine.com China 491 58
Chengdu Baishixing Science and Technology Industry Co.,Ltd
+86-15008457246 yuki@cd-bsx.com China 53 58
Lanxi Xingnuo Import and Export Trading Co., Ltd
+86-15888978871 +86-13901546477 sales@xingnuotraders.com China 163 58
Chengdu ZY Biochemical Technology Co., Ltd.
+86-86-2888626688 +8618980008884 xuehaiying@zybiochem.com China 177 58
Sichuan HongRi Pharma-Tech Co.,Ltd 		+8618382028708 ni@enlaibio.com China 1103 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20121 58
Hangzhou Verychem Science And Technology Co.Ltd 		+86-86-57188162785 13606544505 lucy@verychem.com China 1205 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14026 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21585 55
Supplier Advantage
Suzhou Highfine Biotech Co.,Ltd. 		58
Chengdu Baishixing Science and Technology Industry Co.,Ltd
58
Lanxi Xingnuo Import and Export Trading Co., Ltd
58
Chengdu ZY Biochemical Technology Co., Ltd.
58
Sichuan HongRi Pharma-Tech Co.,Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Hangzhou Verychem Science And Technology Co.Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55

View Lastest Price from Fmoc-His(Trt)-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Fmoc-N'-trityl-L-histidine pictures 2026-07-11 N-Fmoc-N'-trityl-L-histidine
109425-51-6
 $5.00 1kg ≥99% 100mt/year Jinan Finer Chemical Co., Ltd
Fmoc-His(Trt)-OH pictures 2026-07-10 Fmoc-His(Trt)-OH
109425-51-6
 1KG 98%min 500kgs WUHAN FORTUNA CHEMICAL CO., LTD
Fmoc-His(Trt)-OH pictures 2026-07-09 Fmoc-His(Trt)-OH
109425-51-6
 $1.00-2.00 1KG 99% Henan Fengda Chemical Co., Ltd

Fmoc-His(Trt)-OH Spectrum

Fmoc-His(Trt)-OH(109425-51-6)1HNMR

109425-51-6(Fmoc-His(Trt)-OH)Related Search:

L-Fmoc-Aspartic acid alpha-tert-butyl ester Trityl candesartan Nalpha-Fmoc-Ndelta-trityl-L-glutamine Trityl Irbesartan Trityl candesartan cilexetil
Fmoc-Lys(Boc)-OH 9-Fluorenylmethyl chloroformate Fmoc-Asp(OtBu)-OH L-Histidine Triphenylmethyl Chloride
p-Toluic acid Fmoc-Phe-OH N-Fmoc-N'-trityl-D-histidine Fmoc-D-Asn(Trt)-OH N-Fmoc-N'-tosyl-L-arginine
N-Fmoc-S-trityl-D-cysteine Fmoc-OSu N-Boc-N'-trityl-L-glutamine

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FMOC-N-IM-TRITYL-L-HISTIDINE FMOC-HISTIDINE(1-TRT)-OH FMOC-HIS(TRITYL)-OH FMOC-HIS(TRT)-OH FMOC-HIS(T-TRT)-OH FMOC-HIS(1-TRT)-OH FMOC-L-HIS(TRITYL) FMOC-L-HISTIDINE(TRITYL) FMOC-L-HISTIDINE (TRT) Nα-Fmoc-N(im)-trityl-L-histidine N-α-Fmoc-N-im-trityl-L-histidine NALPHA-9-Fluorenylmethoxycarbonyl-N-imidazole-(trityl)-L-histidine FMOC-N-IM-TRITYL-L-HISTIDINE (FMOC-L-HIS(TRT)-OH) N-(ALPHA)-FMOC-N-(TRITYL)-L-HISTIDINE Fmoc-His(trityl resin)-NH2 N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-1-(TRIPHENYLMETHYL)-L-HISTIDINE Fmoc-His(tau-Trt)-OH Nα-Fmoc-Nim-trityl-L-histidine≥ 99.7% (HPLC, Chiral purity) Fmoc-L-His(trityl resin)-NH2 Fmoc-L-histidine(2-chlorotrityl resin)amide (9H-Fluoren-9-yl)MethOxy]Carbonyl His(Trt)-OH N-FMoc-1-trityl-L-histidine, 98% Fmoc-His(Trt)-OH >=98.0% (sum of enantiomers, HPLC) -trityl-L-histidine Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-tele-(triphenylmethyl)-L-histidine Nalpha-Fmoc-tele-trityl-L-histidine Fmoc-His(Trt)-OH ,99% N-FMOC-HIS(TRITYL RESIN)-NH2 N-FMOC-N-TRITYL-L-HISTIDINE Nalpha-(9-fluorenylmethoxycarbonyl)-N-trityl-L-histidine Fmoc-his(trityl)-OH, Fmoc-His(Trt)-OH, Nα-Fmoc-N(im)-trityl-L-histidine Nalpha-FMOC-N-trityl-L-histidine,95% NA-FMOC-NIM-TRITYL-L-HISTIDINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-TAU-TRITYL-L-HISTIDINE N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-NIM-TRITYL-L-HISTIDINE N-9-Fluorenylmethoxycarbonyl-N'-trityl-L-histidine N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-IM-TRITYL-L-HISTIDINE N-ALPHA-FMOC-N-IM-TRITYL-L-HISTIDINE N-Fmoc-N'-trityl-L-h Fmoc-Histidine-(trt)-OH L-HISTIDINE-N-FMOC, N-IM-TRITYL FMoc-His(Trt)-OH N-α-FMoc-N-iM-trityl-L-histidine Nalpha-Fmoc-tele-trityl-L-histidine Fmoc-His(Trt)-OH N^a-FMoc-1-trityl-L-histidine, 98% 2-[[4b,8a,9,9a-tetrahydro-4aH-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-[1-(triphenylmethyl)-4-imidazolyl]propanoic acid Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-tele-(triphenylmethyl)-L-histidine> FMOC-HIS(TRT)-OH 250 G FMOC-HIS(TRT)-OH 100 G FMOC-HIS(TRT)-OH 25 G N-Fmoc-N'-trityL L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)- Fmoc-His(Trt)-OH（plant） Fmoc-His(Trt)-OH Fmoc-His(Trt)-OH -Fmoc-N'-trityl-L-histidine N-Fmoc-N'-trityl-L-histidine USP/EP/BP Nα-Fmoc-Nim-trityl-L-histidine N-Fmoc-N'-trChemicalbookityl-L-histidine Na-FMOC-N(im)-Trityl-L-Histidine (FMOC-His(Trt)-OH) extrapure, 99%