Boc-Glycine hydrazide
- CAS No.
- 6926-09-6
- Chemical Name:
- Boc-Glycine hydrazide
- Synonyms
- BUTTPARK 77\04-08;BOC-GLYCINE HYDRAZIDE;Boc-Glycinehydrazide8%;Boc-Glycinehydrazide，98%;Butoxycarbonylglycine hydrazide;Boc-Glycine hydrazide USP/EP/BP;N-TERT-BUTOXYCARBONYLGLYCYLHYDRAZIDE;tert-Butyl (2-hydrazinyl-2-oxoethyl);2-Aminoacetohydrazide, 2-BOC protected;tert-butyl (2-hydrazino-2-oxoethyl)carbamate
- CBNumber:
- CB9323340
- Molecular Formula:
- C7H15N3O3
- Molecular Weight:
- 189.21
- MDL Number:
- MFCD01570558
- MOL File:
- 6926-09-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 111-115 |
|---|---|
| Boiling point | 386.5±25.0 °C(Predicted) |
| Density | 1.139±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | solid |
| pka | 11.40±0.46(Predicted) |
| color | Beige |
| InChI | InChI=1S/C7H15N3O3/c1-7(2,3)13-6(12)9-4-5(11)10-8/h4,8H2,1-3H3,(H,9,12)(H,10,11) |
| InChIKey | MQBASTZLTYLEON-UHFFFAOYSA-N |
| SMILES | C(NN)(=O)CNC(OC(C)(C)C)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P271-P260-P280 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22 |
| HazardClass | IRRITANT |
| HS Code | 2928009090 |
Boc-Glycine hydrazide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 264256 | Boc-glycine hydrazide Asreported | 6926-09-6 | 1g | $438 | 2026-06-03 | Buy |
| Usbiological | 264256 | Boc-glycine hydrazide Asreported | 6926-09-6 | 2g | $621 | 2026-06-03 | Buy |
| Usbiological | 264256 | Boc-glycine hydrazide Asreported | 6926-09-6 | 5g | $874 | 2026-06-03 | Buy |
| Usbiological | 264256 | Boc-glycine hydrazide Asreported | 6926-09-6 | 10g | $1234 | 2026-06-03 | Buy |
| Usbiological | 264256 | Boc-glycine hydrazide Asreported | 6926-09-6 | 25g | $1770 | 2026-06-03 | Buy |
Boc-Glycine hydrazide Chemical Properties, Uses, Production
Uses
Boc-Glycine hydrazide is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
N-Protected Hydrazides 2a-l; General Procedure The protected amino acid 1 (2 equiv) and EDAC (2 equiv) were dissolved in the minimum amount of CH2Cl2 at 0 C. The mixture was stirred at 0 C for 2 h. PhthNNH2 (1 equiv) was added and the mixture was stirred at 0 C for 1 h and then at r.t. overnight. Distillation of the solvent under reduced pressure gave a product which was dissolved in EtOAc and washed successively with 1 M KHSO4, sat. aq NaHCO3, and brine. The organic layer was then dried (Na2SO4), filtered, and concentrated in vacuo. The residue was precipitated with Et2O to yield compound 2. If necessary, the residue was purified by column chromatography (silica gel, hexane- EtOAc, 3:7 to 7:3). Compounds 4a-l; General Procedure Aminomethylated polystyrene resin (3 equiv; 1.1 mmol/g, 100-200 mesh) was conditioned for 10 min at r.t. in CH2Cl2. Then 2 (1 equiv) was added, and the mixture was slowly stirred for 24 h at r.t. The mixture was filtered and the solvent was evaporated in vacuo to give product 4. Compound 4h, yield 89%.
References
[1] Tetrahedron Letters, 2016, vol. 57, # 9, p. 990 - 992
[2] Patent: US2004/19215, 2004, A1. Location in patent: Page 6
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 5, p. 2124 - 2130
[4] Journal of Organic Chemistry, 1995, vol. 60, # 10, p. 3112 - 3120
[5] Combinatorial Chemistry and High Throughput Screening, 2011, vol. 14, # 2, p. 132 - 137
Boc-Glycine hydrazide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Liheng Biotechnology Co., Ltd. | 0531-18763987518 18763987518 | levi@lihengpharm.com | China | 1760 | 58 |
| Shanghai Chiral Chemicals Inc. | 021-37285021 13472570865 | tym7xi@aliyun.com | China | 299 | 64 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Changzhou Wanyao Biotechnology Co., Ltd. | 0519-89185693 15312551983 | 2410037592@qq.com | China | 278 | 55 |
| Shanghai yirong biology science and technology co., ltd | 18049974220 | 3060526242@qq.com | China | 999 | 60 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
