5-Methoxybenzimidazole
- CAS No.
- 4887-80-3
- Chemical Name:
- 5-Methoxybenzimidazole
- Synonyms
- 5-METHOXY-1H-BENZIMIDAZOLE;BUTTPARK 146\15-76;5-Methoxybenzimidazole;1H-Benzimidazole,5-meth;Esomeprazole Impurity 106;6-methoxy-1H-benzimidazole;5-Methoxybenzimidazole,97%;5-Methoxybenzimidazole 97%;5-Methoxybenzimidazole,99%;5-Methoxy-1H-benzoiMidazole
- CBNumber:
- CB9457735
- Molecular Formula:
- C8H8N2O
- Molecular Weight:
- 148.16
- MDL Number:
- MFCD00272526
- MOL File:
- 4887-80-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 121-126 °C (lit.) |
|---|---|
| Boiling point | 190-195 °C(Press: 0.03 Torr) |
| Density | 1.244±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | solid |
| pka | 13.12±0.10(Predicted) |
| color | Light brown to brown |
| InChI | InChI=1S/C8H8N2O/c1-11-6-2-3-7-8(4-6)10-5-9-7/h2-5H,1H3,(H,9,10) |
| InChIKey | ILMHAGCURJPNRZ-UHFFFAOYSA-N |
| SMILES | C1NC2=CC(OC)=CC=C2N=1 |
| CAS DataBase Reference | 4887-80-3(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P280a-P304+P340-P405-P501a | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29332990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-Methoxybenzimidazole price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 515108 | 5-Methoxybenzimidazole 97% | 4887-80-3 | 5g | $186 | 2022-05-15 | Buy |
| Apolloscientific | OR11201 | 5-Methoxy-1H-benzimidazole 98% | 4887-80-3 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR11201 | 5-Methoxy-1H-benzimidazole 98% | 4887-80-3 | 5g | $49 | 2026-06-04 | Buy |
| Apolloscientific | OR11201 | 5-Methoxy-1H-benzimidazole 98% | 4887-80-3 | 10g | $83 | 2026-06-04 | Buy |
| Activate Scientific | AS113329 | 5-Methoxy-1H-benzo[d]imidazole 98% | 4887-80-3 | 1g | $24 | 2026-06-04 | Buy |
5-Methoxybenzimidazole Chemical Properties, Uses, Production
Chemical Properties
White to brown powder
Uses
6-Methoxy-1H-benzimidazole has been studied for its anti-proliferative activity, and a preliminary in vivo toxicity study against a panel of non-small cell lung cancer cell lines.
Synthesis
22019-71-2
4887-80-3
To a 16 mL reaction flask equipped with a PTFE/silicone septum and a nitrogen bubbler was added N-benzylbenzimidazole (208.1 mg, 1.0 mmol), dried Pd/C catalyst (10 wt%, 20 mg) and THF (5 mL). Triethylsilane (320 μL, 2.0 mmol) was added dropwise to the mixture under nitrogen protection, followed by continuous stirring at room temperature for 14 hours. After completion of the reaction, the reaction mixture was filtered through a 0.45 μm PTFE syringe filter and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (eluent: 0 to 10% methanol/dichloromethane gradient) to afford 5-methoxybenzimidazole as a colorless solid (117.6 mg, 0.996 mmol, 99% yield). It is worth noting that the reaction typically suffers from an induction period of 5 to 30 min, which can be observed by the release of gas from the reaction mixture (i.e., the bubbling phenomenon). The use of a dry Pd/C catalyst is critical to the success of the reaction, and wet Pd/C may result in a significant decrease in yield or inability of the reaction to proceed.
References
[1] Tetrahedron Letters, 2015, vol. 56, # 21, p. 2688 - 2690
5-Methoxybenzimidazole Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CHANGZHOU MALONG CHEMICALS CO., LTD. | 18651958646 | info@malongchem.com | China | 185 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Suzhou Ryan Pharmaceutical Technology Co., Ltd. | 0512-68780025 18962125825 | sales@ryanchem.com | China | 169 | 62 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 |
View Latest Price from 5-Methoxybenzimidazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | 5-METHOXYBENZIMIDAZOLE
4887-80-3
|
$1.00-2.10 | 1KG | 99% | 20000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-07-13 | 5-METHOXYBENZIMIDAZOLE
4887-80-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 5-METHOXYBENZIMIDAZOLE
4887-80-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 5-METHOXYBENZIMIDAZOLE
4887-80-3
- $1.00-2.10
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-METHOXYBENZIMIDAZOLE
4887-80-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-METHOXYBENZIMIDAZOLE
4887-80-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
