2,3-Dichloropyridine-4-carboxaldehyde
- CAS No.
- 884495-41-4
- Chemical Name:
- 2,3-Dichloropyridine-4-carboxaldehyde
- Synonyms
- 2,3-dichloroisonicotinaldehyde;2,3-dichloropyridine-4-carbaldehyde;2,3-Dichloro-4-pyridinecarboxaldehyde;2,3-Dichloropyridine-4-carboxaldehyde;4-Pyridinecarboxaldehyde, 2,3-dichloro-;2,3-dichloro-5-forMylpyridine-4-carboxylic acid;2,3-Dichloropyridine-4-carboxaldehyde ISO 9001：2015 REACH;2,3-Dichloropyridine-2,3-Dichloropyridine-4-carboxaldehyde4-carboxaldehyde
- CBNumber:
- CB9967298
- Molecular Formula:
- C6H3Cl2NO
- Molecular Weight:
- 176
- MDL Number:
- MFCD08277282
- MOL File:
- 884495-41-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
2,3-Dichloropyridine-4-carboxaldehyde price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR303667 | 2,3-Dichloroisonicotinaldehyde 97% | 884495-41-4 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR303667 | 2,3-Dichloroisonicotinaldehyde 97% | 884495-41-4 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR303667 | 2,3-Dichloroisonicotinaldehyde 97% | 884495-41-4 | 5g | $60 | 2026-06-04 | Buy |
| Apolloscientific | OR303667 | 2,3-Dichloroisonicotinaldehyde 97% | 884495-41-4 | 25g | $176 | 2026-06-04 | Buy |
| Activate Scientific | AS46933 | 2,3-Dichloroisonicotinaldehyde 97% | 884495-41-4 | 1g | $29 | 2026-06-04 | Buy |
2,3-Dichloropyridine-4-carboxaldehyde Chemical Properties, Uses, Production
Uses
2,3-Dichloroisonicotinaldehyde is used in preparation of spiroaminoindene piperidines as Shp2 phosphatase inhibitors for treatment of disorders associated with SHP2 deregulation.
Synthesis
2402-77-9
68-12-2
884495-41-4
General procedure: 2,3-dichloropyridine (10 g, 67.57 mmol) was dissolved in dry tetrahydrofuran (200 ml) under nitrogen protection and cooled to -78 °C. A hexane solution of n-butyllithium (37.165 ml, 74 mmol, 2M) was added slowly and dropwise. The reaction mixture was stirred at -78°C for 20 min and then dry N,N-dimethylformamide (6.28 ml, 81.087 mmol) was added dropwise. Stirring was continued at -78 °C for 15 min, followed by slow warming of the reaction mixture to room temperature. Upon completion of the reaction, the reaction was quenched with water and extracted with dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was initially purified by fast column chromatography (dichloromethane as eluent). The fraction containing 2,3-dichloropyridine-4-carbaldehyde was collected and concentrated under reduced pressure to give the crude product. It was further purified by column chromatography (silica gel; dichloromethane/heptane as eluent, gradient elution to 50%). The target fraction was collected and concentrated under reduced pressure to afford the intermediate compound D41 (4.15 g, 34.9% yield) as a white solid.GC-MS retention time (min): 7.9.
References
[1] Patent: WO2009/62676, 2009, A2. Location in patent: Page/Page column 65
[2] Patent: WO2010/130424, 2010, A1. Location in patent: Page/Page column 109-110
[3] Patent: US2010/298334, 2010, A1. Location in patent: Page/Page column 57
2,3-Dichloropyridine-4-carboxaldehyde Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Raise Pharmatech Co., Ltd. | 025-58649566 15005191108 | sales@njboyuanchem.com | China | 113 | 60 |
| Hebei Summedchem Co.,Ltd | 0319-5801333-8008 15630992918 | sales@summedchem.com | China | 1000 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
View Latest Price from 2,3-Dichloropyridine-4-carboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 2,3-Dichloropyridine-4-carboxaldehyde
884495-41-4
|
1G | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2026-08-20 | 2,3-Dichloropyridine-4-carboxaldehyde
884495-41-4
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2025-04-04 | 2,3-Dichloropyridine-4-carboxaldehyde
884495-41-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2,3-Dichloropyridine-4-carboxaldehyde
884495-41-4
- $0.00
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 2,3-Dichloropyridine-4-carboxaldehyde
884495-41-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2,3-Dichloropyridine-4-carboxaldehyde
884495-41-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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