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| | DBCO-PEG1-amine Basic information |
| | DBCO-PEG1-amine Chemical Properties |
| Boiling point | 730.9±60.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 15.15±0.46(Predicted) |
| | DBCO-PEG1-amine Usage And Synthesis |
| Description | DBCO-PEG1-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. | | Uses | DBCO-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG1-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | DBCO-PEG1-amine Preparation Products And Raw materials |
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