DBCO-PEG2-NH-Boc

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DBCO-PEG2-NH-Boc manufacturers
DBCO-PEG2-NH-Boc Basic information
Product Name:DBCO-PEG2-NH-Boc
Synonyms:DBCO-PEG2-NH-Boc;DBCO-PEG2-t-Bu Amine;DBCO-PEG2-Boc Amine
CAS:2377004-08-3
MF:C30H37N3O6
MW:535.63
EINECS:
Product Categories:
Mol File:2377004-08-3.mol
DBCO-PEG2-NH-Boc Structure
DBCO-PEG2-NH-Boc Chemical Properties
Boiling point 802.8±65.0 °C(Predicted)
density 1.22±0.1 g/cm3(Predicted)
solubility Soluble in DMSO, DCM, DMF
pka12.23±0.46(Predicted)
Safety Information
MSDS Information
DBCO-PEG2-NH-Boc Usage And Synthesis
DescriptionDBCO-PEG2-NH-Boc is a PEG linker with a DBCO group and a Boc-protected amine. The DBCO can undergo copper-free Click Chemistry reactions with azides. The Boc protecting group can be removed under acidic conditions to further react.
UsesDBCO-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG2-NH-Boc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
IC 50PEGs; Alkyl/ether
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
DBCO-PEG2-NH-Boc Preparation Products And Raw materials
Tag:DBCO-PEG2-NH-Boc(2377004-08-3) Related Product Information
DBCO-PEG1-amine 5,8,11,14,17,20-Hexaoxa-2,23-diazaheptacosanoic acid, 27-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-24,27-dioxo-, 1,1-dimethylethyl ester DBCO-PEG3-CH2CO-NHS DBCO-PEG4-amine DBCO-PEG4-SE DBCO-NHS Ester Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester DBCO-PEG4-DBCO DBCO-(CH2)2-NH2-co-(CH2)3COOH-NHS DBCO-PEG3-acid Azadibenzocyclooctyne-Biotin conjugate 4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-(11,12-dihydrodibenz[b,f]azocin-5(6H)-yl)-17,21-dioxo-, 2,3,5,6-tetrafluorophenyl ester DBCO-NH-(CH2)4COOH DBCO-PEG3-amine DBCO-NH-Boc