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| | 3-Bromo-5-methoxypyridine Basic information |
| | 3-Bromo-5-methoxypyridine Chemical Properties |
| Melting point | 31-35 °C (lit.) | | Boiling point | 212.2±20.0 °C(Predicted) | | density | 1.530±0.06 g/cm3(Predicted) | | Fp | 215 °F | | storage temp. | Inert atmosphere,Room Temperature | | solubility | soluble in Methanol | | pka | 2.26±0.10(Predicted) | | form | Low Melting Solid | | color | White to yellow | | InChI | InChI=1S/C6H6BrNO/c1-9-6-2-5(7)3-8-4-6/h2-4H,1H3 | | InChIKey | FZWUIWQMJFAWJW-UHFFFAOYSA-N | | SMILES | C1=NC=C(OC)C=C1Br | | CAS DataBase Reference | 50720-12-2(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | HazardClass | IRRITANT, IRRITANT-HARMFUL | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1 |
| | 3-Bromo-5-methoxypyridine Usage And Synthesis |
| Chemical Properties | White to yellow low melting solid | | Uses | 3-Bromo-5-methoxypyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | | Synthesis | Example 7A Synthesis of 3-bromo-5-methoxypyridine: Methanol (180 mL) was treated batchwise with sodium pellets (4.7 g, 0.20 mol) under dry conditions and subsequently evaporated to dryness. The residue was azeotroped with toluene (100 mL) and then concentrated under reduced pressure to completely remove water. To dry DMF (130 mL), the sodium methanol solution prepared above was added, followed by 3,5-dibromopyridine (32 g, 135 mmol, purchased from Avocado Chemicals). The reaction mixture was heated at 70 °C for 4 hours. After completion of the reaction, the mixture was slowly poured into an ice/water mixture (300 g) and the precipitate was collected by filtration. The filter cake was dried under reduced pressure to give the target product 3-bromo-5-methoxypyridine (15.6 g, 62% yield). Mass spectrometry analysis (DCI/NH3) showed m/z 188/190 (M + H)+, confirming the product structure. | | References | [1] Patent: US2002/19388, 2002, A1
[2] Recueil des Travaux Chimiques des Pays-Bas, 1955, vol. 74, p. 1171,1174
[3] Patent: US6392045, 2002, B1
[4] Patent: US5948793, 1999, A
[5] Patent: US6127386, 2000, A |
| | 3-Bromo-5-methoxypyridine Preparation Products And Raw materials |
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