- 3-Bromo-5-methylpyridine
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- $5.00 / 1KG
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2025-09-25
- CAS:3430-16-8
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: g-kg-tons, free sample is available
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| | 3-Bromo-5-methylpyridine Basic information |
| | 3-Bromo-5-methylpyridine Chemical Properties |
| Melting point | 16.5-16.7 °C | | Boiling point | 110°C/25mmHg(lit.) | | density | 1.4869 g/mL at 25 °C | | refractive index | 1.5618 | | Fp | 91 °C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 3.16±0.20(Predicted) | | form | powder to lump to clear liquid | | color | White or Colorless to Almost white or Almost colorless | | InChI | 1S/C6H6BrN/c1-5-2-6(7)4-8-3-5/h2-4H,1H3 | | InChIKey | ADCLTLQMVAEBLB-UHFFFAOYSA-N | | SMILES | Cc1cncc(Br)c1 | | CAS DataBase Reference | 3430-16-8(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-41-22 | | Safety Statements | 26-36/37/39-39 | | RIDADR | NA 1993 / PGIII | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933399990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1 |
| | 3-Bromo-5-methylpyridine Usage And Synthesis |
| Chemical Properties | Light yellow liquid | | Uses | 5-Bromo-3-picoline is an intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity | | Synthesis | The general procedure for the synthesis of 3-bromo-5-methylpyridine from 3,5-dibromopyridine and trimethylcyclotriboroxane was as follows: under nitrogen protection, cesium carbonate (1.38 g, 4.22 mmol), trimethylcyclotriboroxane (0.2 mL, 1.47 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.488 g, 0.42 mmol ). Subsequently, a solution of 3,5-dibromopyridine (1.0 g, 4.22 mmol) dissolved in a 9:1 solvent mixture of dioxane and water (10 mL) was added. The reaction mixture was stirred at 110 °C for 16 hours. Upon completion of the reaction, trimethylcyclotriboroxane (0.2 mL, 1.47 mmol) was added again and the reaction temperature was lowered to 100 °C and the reaction continued to be stirred for 16 hours. At the end of the reaction, the reaction mixture was cooled to room temperature, filtered through diatomaceous earth and the filter cake was washed with ethyl acetate. The filtrate was concentrated and the resulting residue was purified by silica gel column chromatography with the eluent being a 80:20 solvent mixture of hexane and ethyl acetate, resulting in 3-bromo-5-methylpyridine as a colorless oil (0.654 g, 90% yield). The product was identified by 1H NMR (300 MHz, CDCl3): δ 2.34 (s, 3H), 7.66 (s, 1H), 8.36 (s, 1H), 8.49 (s, 1H).GC-MS (EI) analysis showed: m/z = 171.0, 173.0 [M]. | | References | [1] Patent: WO2005/94822, 2005, A1. Location in patent: Page/Page column 25 |
| | 3-Bromo-5-methylpyridine Preparation Products And Raw materials |
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