|
|
| | (6-Chloro-2-pyridinyl)methanol Basic information |
| Product Name: | (6-Chloro-2-pyridinyl)methanol | | Synonyms: | CHEMPACIFIC 38159;(6-CHLORO-PYRIDIN-2-YL)-METHANOL;(6-Chloro-2-pyridinyl)methanol;2-Chloro-6-(Hydroxymethyl)Pyridine;6-Chloro-2-pyridinemethanol;2-Chloropyridine-6-Methanol;2-Pyridinemethanol, 6-chloro-;(6-Chloro-2-pyridinyl)methanol ISO 9001：2015 REACH | | CAS: | 33674-97-4 | | MF: | C6H6ClNO | | MW: | 143.57 | | EINECS: | 807-010-1 | | Product Categories: | | | Mol File: | 33674-97-4.mol |  |
| | (6-Chloro-2-pyridinyl)methanol Chemical Properties |
| Boiling point | 251.8±25.0 °C(Predicted) | | density | 1.324±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | liquid | | pka | 13.12±0.10(Predicted) | | color | Colourless |
| HazardClass | IRRITANT | | HS Code | 2933399990 |
| | (6-Chloro-2-pyridinyl)methanol Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-chloro-6-hydroxymethylpyridine from methyl 6-chloropyridine-2-carboxylate: 6.7 g (39.0 mmol) of methyl 6-chloropyridine-2-carboxylate was dissolved in 90 mL of anhydrous tetrahydrofuran, which was subsequently cooled to -45 °C. A 40 mL solution of 1 M lithium aluminum hydride in tetrahydrofuran was added slowly and dropwise over 30 min. The reaction mixture was stirred at -45°C for 30 minutes and then slowly warmed to 0°C and continued stirring for 30 minutes. Subsequently, 15 mL of 1 N aqueous sodium hydroxide solution was slowly added dropwise to quench the reaction. Solid impurities were removed by diatomaceous earth filtration and the filtrate was concentrated to give 5.08 g (35.4 mmol, 91% yield) of 2-chloro-6-hydroxymethylpyridine. The product was characterized by 1H NMR (CDCl3, ppm): δ 7.61 (1H, d), 7.30 (1H, t), 7.04 (1H, d), 3.72 (2H, s).FAB MS (m/z) = 144 [M + 1]. | | References | [1] Patent: WO2007/58482, 2007, A1. Location in patent: Page/Page column 47-48 |
| | (6-Chloro-2-pyridinyl)methanol Preparation Products And Raw materials |
|