Azido-PEG3-Sulfone-PEG4-t-butyl ester

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Azido-PEG3-Sulfone-PEG4-t-butyl ester Basic information
Product Name:Azido-PEG3-Sulfone-PEG4-t-butyl ester
Synonyms:Azido-PEG3-Sulfone-PEG4-t-butyl ester;Azido-PEG3-Sulfone-PEG4-Boc;tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylsulfonyl]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
CAS:2055023-76-0
MF:C23H45N3O11S
MW:571.6819
EINECS:
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Mol File:2055023-76-0.mol
Azido-PEG3-Sulfone-PEG4-t-butyl ester Structure
Azido-PEG3-Sulfone-PEG4-t-butyl ester Chemical Properties
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MSDS Information
Azido-PEG3-Sulfone-PEG4-t-butyl ester Usage And Synthesis
DescriptionAzido-PEG3-Sulfone-PEG4-t-butyl ester is a PEG linker containing one azide group and one t-butyl protected carboxyl group. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions.
UsesAzido-PEG3-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-Sulfone-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50PEGs
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG3-Sulfone-PEG4-t-butyl ester Preparation Products And Raw materials
Tag:Azido-PEG3-Sulfone-PEG4-t-butyl ester(2055023-76-0) Related Product Information
1,11-Diazido-3,6,9-trioxaundecane 2-[2-(2-Azidoethoxy)ethoxy]ethanol 11-Azido-3 6 9-trioxaundecan-1-amine Azido-PEG3-Sulfone-PEG4-acid Bromo-PEG3-azide Azide-PEG3-Sulfone-PEG3-Azide Azido-PEG3-NHS ester Azide-PEG3-Tos N3-PEG3-Hydrazide Azido-dPEG4-acid N3-PEG3-tBu