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| | Azide-PEG3-Sulfone-PEG3-Azide Basic information |
| | Azide-PEG3-Sulfone-PEG3-Azide Chemical Properties |
| | Azide-PEG3-Sulfone-PEG3-Azide Usage And Synthesis |
| Description | Azide-PEG3-Sulfone-PEG3-azide is a PEG linker containing two azide groups. The azide group enables Click Chemistry with groups such as alkynes, DBCO and BCN. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Azide-PEG3-Sulfone-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Sulfone-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azide-PEG3-Sulfone-PEG3-Azide Preparation Products And Raw materials |
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