Azido-PEG3-Maleimide

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Azido-PEG3-Maleimide manufacturers
Azido-PEG3-Maleimide Basic information
Product Name:Azido-PEG3-Maleimide
Synonyms:Azido-PEG3-Maleimide;N3-PEG3-Mal;Azide-PEG3-maleimide;Azido-PEG4-BMPA;1H-Pyrrole-1-propanamide, N-[2-[2-[2-(2-azidoethoxy) ethoxy] ethoxy] ethyl]-2,5-dihydro-2,5-dioxo-
CAS:1858264-36-4
MF:C15H23N5O6
MW:369.37302
EINECS:
Product Categories:peg
Mol File:1858264-36-4.mol
Azido-PEG3-Maleimide Structure
Azido-PEG3-Maleimide Chemical Properties
Safety Information
MSDS Information
Azido-PEG3-Maleimide Usage And Synthesis
DescriptionAzido-PEG3-Maleimide is provided as a kit of two vials. Azido-PEG3-Maleimide is not stable for storage; it needs to be made in situ by mixing Azido-PEG3-amine and Maleimide-NHS ester followed by shaking/ stirring for 30 minutes at room temperature. The maleimide group of the Azido-PEG3-Maleimide can react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. Azide group enables Click Chemsitry reactions.
Biological ActivityAzido-PEG3-maleimide is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules. Azido-PEG3-maleimide is also a cleavable ADC linker containing 3-unit PEG, which can be used to synthesize antibody drug conjugates (ADCs).
in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

PEGs

Cleavable

Azido-PEG3-Maleimide Preparation Products And Raw materials
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