Aminooxy-PEG4-azide manufacturers
- Aminooxy-PEG4-azide
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2025-06-07
- CAS:2100306-61-2
- Min. Order: 500mg
- Purity: >98.00%
- Supply Ability: 500mg
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| | Aminooxy-PEG4-azide Basic information |
| | Aminooxy-PEG4-azide Chemical Properties |
| | Aminooxy-PEG4-azide Usage And Synthesis |
| Description | Aminooxy-PEG4-azide is a heterobifunctional crosslinker containing an aminooxy group and an azide group. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | | Uses | Aminooxy-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminooxy-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
| | Aminooxy-PEG4-azide Preparation Products And Raw materials |
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