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| | 2,4-Dibromo-1-fluorobenzene Basic information |
| Product Name: | 2,4-Dibromo-1-fluorobenzene | | Synonyms: | Benzene, 2,4-dibromo-1-fluoro-;1,3-DIBROMO-4-FLUOROBENZENE;1-FLUORO-2,4-DIBROMOBENZENE;2,4-DIBROMO-1-FLUOROBENZENE;1,3-Dibromo-4-fluorobenzene, tech., 85%;1,3-Dibromo-4-fluorobenzene 98%;1,3-Dibromo-4-fluorobenzene98%;2,4-DIBROMO-1-FLUOROBENZENE: TECH., 90% | | CAS: | 1435-53-6 | | MF: | C6H3Br2F | | MW: | 253.89 | | EINECS: | 215-860-4 | | Product Categories: | Fluorine series;Bromine Compounds;Fluorine Compounds;Aryl;Halogenated Hydrocarbons;Aromatic Hydrocarbons (substituted) & Derivatives;Fluorobenzene;C6 | | Mol File: | 1435-53-6.mol |  |
| | 2,4-Dibromo-1-fluorobenzene Chemical Properties |
| Melting point | 69°C | | Boiling point | 105-110 °C (22 mmHg) | | density | 2.047 g/mL at 25 °C(lit.) | | refractive index | 1.582-1.584 | | Fp | 92 °C | | storage temp. | Sealed in dry,Room Temperature | | form | Liquid | | color | Clear colorless | | Specific Gravity | 2.047 | | Water Solubility | insoluble | | BRN | 1934822 | | CAS DataBase Reference | 1435-53-6(CAS DataBase Reference) | | NIST Chemistry Reference | 2,4-Dibromo-1-fluorobenzene(1435-53-6) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26 | | RIDADR | NA 1993 / PGIII | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29036990 |
| | 2,4-Dibromo-1-fluorobenzene Usage And Synthesis |
| Chemical Properties | clear colorless liquid | | Uses | 2,4-Dibromo-1-fluorobenzene is used as an intermediate in pharmaceuticals, pesticides, and liquid crystal materials, as well as in the research of regional selective lithiation of halogenated aromatics and the synthesis of novel pyrethroids. | | Synthesis | The general procedure for synthesizing 2,4-dibromofluorobenzene from 2-fluoro-5-bromobenzoic acid is as follows: in Example 6, bromoisocyanurate was used to induce the bromination reaction of aromatic carboxylic acids. This was done as follows: a mixture of 2-fluoro-5-bromobenzoic acid (1 mmol), bromoisocyanuric acid ester, additives and solvent (10 mL) was stirred under fluorescent room light (FL) or warm white 3W LED (LL) irradiation. Upon completion of the reaction, the reaction mixture is washed with 1 M aqueous Na2SO3, dried over Na2SO4, filtered through a short pad of neutral alumina, and concentrated under vacuum to give crude 2,4-dibromofluorobenzene. The crude product can be purified by silica gel chromatography as required. The experimental results are detailed in Table 5. | | References | [1] Patent: WO2017/60905, 2017, A1. Location in patent: Paragraph 00139; 00153 |
| | 2,4-Dibromo-1-fluorobenzene Preparation Products And Raw materials |
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