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| | 6-fluoro-2-methylindan-1-one Basic information |
| Product Name: | 6-fluoro-2-methylindan-1-one | | Synonyms: | 6-FLUORO-2-METHYLINDANONE;2-Methyl-6-fluoro-1-indanone;2-METYL-6-FLUORO-1-INDANONE;6-Fluoro-2-methylindan-1-one;6-fluoro-2,3-dihydro-2-Methylinden-1-one;6-FLUORO-2-METHYL-2,3-DIHYDROINDEN-1-ON;6-Fluoro-2-methyl-2,3-dihydro-1-indenone;1H-Inden-1-one, 6-fluoro-2,3-dihydro-2-methyl- | | CAS: | 37794-19-7 | | MF: | C10H9FO | | MW: | 164.18 | | EINECS: | 609-478-0 | | Product Categories: | PHARMACEUTICAL INTERMEDIATES | | Mol File: | 37794-19-7.mol |  |
| | 6-fluoro-2-methylindan-1-one Chemical Properties |
| Boiling point | 240.9±29.0 °C(Predicted) | | density | 1.179±0.06 g/cm3(Predicted) | | vapor pressure | 3.07Pa at 25℃ | | storage temp. | Sealed in dry,Room Temperature | | Water Solubility | 307.4mg/L at 25℃ | | InChI | InChI=1S/C10H9FO/c1-6-4-7-2-3-8(11)5-9(7)10(6)12/h2-3,5-6H,4H2,1H3 | | InChIKey | BABIQLUCYVRCIX-UHFFFAOYSA-N | | SMILES | C1(=O)C2=C(C=CC(F)=C2)CC1C | | LogP | 2.73 | | CAS DataBase Reference | 37794-19-7(CAS DataBase Reference) |
| HazardClass | IRRITANT | | HS Code | 2914790090 |
| | 6-fluoro-2-methylindan-1-one Usage And Synthesis |
| Uses | 6-Fluoro-2-methylindan-1-one is a key intermediate in the synthesis of sulindac. This compound is converted to sulindac via hydrolysis following condensation with cyanoacetic acid, followed by condensation with p-methylthiobenzaldehyde and subsequent oxidation. Sulindac is a non-steroidal prodrug with minimal biological activity; once it enters the body, it is metabolised into an active sulphide compound. This compound inhibits cyclooxygenase and reduces the synthesis of prostaglandins, thereby exerting analgesic, anti-inflammatory and antipyretic effects. It is primarily used to treat pain, rheumatoid arthritis, ankylosing spondylitis and gouty arthritis. | | Hazard | 6-fluoro-2-methylindan-1-one is irritating to humans. Contact may cause skin irritation and severe eye irritation, and may also cause respiratory tract irritation. Therefore, wear a protective face mask when using this substance. |
| | 6-fluoro-2-methylindan-1-one Preparation Products And Raw materials |
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