- 1-Indanone
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-
2026-09-23
- CAS:83-33-0
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 30tons/month
- 1-Indanone
-
-
2026-09-23
- CAS:83-33-0
- Min. Order: 1g
- Purity: More Than 99%
- Supply Ability: 100kg/Month
- 1-Indanone
-
-
2026-08-29
- CAS:83-33-0
- Purity: 99.91%
- Supply Ability: 10g
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| | 1-Indanone Basic information |
| | 1-Indanone Chemical Properties |
| Melting point | 38-40 °C(lit.) | | Boiling point | 243-245 °C(lit.) | | density | 1.103 g/mL at 25 °C(lit.) | | refractive index | 1.5610 (estimate) | | Fp | 233 °F | | storage temp. | Store below +30°C. | | solubility | 6.5g/l | | form | Crystalline Mass | | color | Light yellow to brown | | Odor | Rather weak, woody and somewhat medicinal odor with an incense-like undertone. | | biological source | mouse | | Odor Threshold | 0.0088ppm | | Water Solubility | 6.5 g/L (20 C) | | BRN | 507957 | | Stability: | Light sensitive | | InChI | 1S/C9H8O/c10-9-6-5-7-3-1-2-4-8(7)9/h1-4H,5-6H2 | | InChIKey | QNXSIUBBGPHDDE-UHFFFAOYSA-N | | SMILES | O=C1CCc2ccccc12 | | CAS DataBase Reference | 83-33-0(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-Inden-1-one, 2,3-dihydro-(83-33-0) | | EPA Substance Registry System | 1H-Inden-1-one, 2,3-dihydro- (83-33-0) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 22-24/25-36-26 | | WGK Germany | 3 | | Autoignition Temperature | 525 °C | | Hazard Note | Irritant | | TSCA | TSCA listed | | HS Code | 29143900 | | Storage Class | 11 - Combustible Solids |
| | 1-Indanone Usage And Synthesis |
| Description | 1-Indanone is an important skeletal structure with a wide range of biological activities. Extensive research has demonstrated that 1-indanone derivatives play a significant role in the development of drugs for the treatment of Alzheimer's disease, as well as in anti-diarrhoeal, anti-proliferative, antibacterial, anti-inflammatory and anti-cancer agents[1]. | | Chemical Properties | Pale yellow liquid | | Uses | 1-Indanone is an oxidation product of Indan, a component of fuels, solvents, and varnishes. 1-Indanone is also a metabolite of Thalidomide that has been shown to inhibit the attachment of tumor cells to concanavalin A coated plastic surfaces. | | Uses | 1-Indanone is an oxidation product of indan, a component of fuels, solvents and varnishes. 1-Indanone is also a metabolite of Thalidomide that has been shown to inhibit the attachment of tumor cells to concanavalin A coated plastic surfaces. | | Definition | ChEBI: An indanone that consists of 2,3-dihydro-1H-indene substituted by an oxo group at position 1. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 54, p. 1144, 1989 DOI: 10.1021/jo00266a028
Journal of the American Chemical Society, 99, p. 4822, 1977 DOI: 10.1021/ja00456a048
Tetrahedron Letters, 27, p. 3139, 1986 DOI: 10.1016/S0040-4039(00)84736-X | | Biological Activity | Indoleamine 2,3 dioxygenase (IDO) 1 plays an important role in the metabolism of tryptophan and in immune regulation. Removal of IDO1 results in attenuated contact hypersensitivity (CHS) responses. | | Synthesis | 1-Indanone is produced by cyclization of be{a-Phenylpropionyl chloride in Benzene. | | References | [1] Mei Zuo . (2025). Synthesis, X-ray, DFT and antibacterial activity of a novel 1-indanone derivative. Journal of Molecular Structure, 1339, Article 142422. https://doi.org/10.1016/j.molstruc.2025.142422 |
| | 1-Indanone Preparation Products And Raw materials |
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