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- JNJ16259685
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- $92.00
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2026-07-14
- CAS:409345-29-5
- Purity: 99.39%
- Supply Ability: 10g
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| | JNJ 16259685 Basic information |
| Product Name: | JNJ 16259685 | | Synonyms: | (3,4-DIHYDRO-2H-PYRANO[2,3-B]QUINOLIN-7-YL)-(CIS-4-METHOXYCYCLOHEXYL)-METHANONE;JNJ 16259685;JNJ16259865;CS-2455;3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl-(4-methoxycyclohexyl)methanone;.TN.T 16259685;inhibit,Inhibitor,mGluR,JNJ16259685,JNJ 16259685,JNJ-16259685,Metabotropic glutamate receptors;Methanone, (3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(cis-4-methoxycyclohexyl)- | | CAS: | 409345-29-5 | | MF: | C20H23NO3 | | MW: | 325.4 | | EINECS: | | | Product Categories: | Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 409345-29-5.mol |  |
| | JNJ 16259685 Chemical Properties |
| Melting point | 102-104°C | | Boiling point | 502.5±50.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | Chloroform (Slightly), DMSO (Slightly) | | pka | 2.60±0.20(Predicted) | | form | White to off-white solid. | | color | White to Off-White |
| | JNJ 16259685 Usage And Synthesis |
| Uses | JNJ 16259685 is a metabotropic glutamate receptor-1 antagonist that alters select behavior in mouse model of fragile X syndrome. | | Definition | ChEBI: 3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl-(4-methoxycyclohexyl)methanone is an organonitrogen heterocyclic compound, an oxacycle and an organic heterotricyclic compound. | | in vivo | JNJ16259685 (0.125, 0.25, 0.5, 1, 2, 4 and 8 mg/kg, i.p) significantly reduces the time spent in digging behaviours (0.25-8 mg/kg), threat (all doses) and attack, in comparison with vehicle group[1]. JNJ16259685 (30 mg/kg) produces very minimal effects on locomotor activity. JNJ16259685 dramatically reduces rearing behavior, exploration of a novel environment and lever pressing for a food reward (rat: 0.3 mg/kg; mouse: 1 mg/kg). Subcutaneously administered JNJ16259685 (30 mg/kg) has no effect on reflexive startle responses to loud auditory stimuli or foot shock in mice[2]. JNJ16259685 exhibits high potencies in occupying central mGlu1 receptors in the rat cerebellum and thalamus (ED50=0.040 and 0.014 mg/kg, respectively)[3]. | | IC 50 | mGluR1: 19 nM (IC50) | | storage | +4°C |
| | JNJ 16259685 Preparation Products And Raw materials |
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