4-HYDROXY-6-METHYLQUINAZOLINE manufacturers
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| | 4-HYDROXY-6-METHYLQUINAZOLINE Basic information |
| Product Name: | 4-HYDROXY-6-METHYLQUINAZOLINE | | Synonyms: | 4-HYDROXY-6-METHYLQUINAZOLINE;BUTTPARK 51\07-11;3,4-Dihydro-6-methyl-4-oxoquinazoline;3,4-Dihydro-6-methyl-4-oxoquinazoline 98%;4-Hydroxy-6-methylquinazoline 97%;4-Hydroxy-6-methylquinazoline97%;6-methyl-4-quinazolinone;6-methylquinazolin-4-ol | | CAS: | 19181-53-4 | | MF: | C9H8N2O | | MW: | 160.17 | | EINECS: | | | Product Categories: | blocks;Heterocycles;Quinolines | | Mol File: | 19181-53-4.mol |  |
| | 4-HYDROXY-6-METHYLQUINAZOLINE Chemical Properties |
| Melting point | 238-240 | | Boiling point | 334.6±35.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 2.06±0.20(Predicted) | | Appearance | White to off-white Solid |
| Hazard Codes | Xi | | Hazard Note | Irritant | | HS Code | 2933399990 |
| | 4-HYDROXY-6-METHYLQUINAZOLINE Usage And Synthesis |
| Synthesis | Concentrated hydrochloric acid (4.16 mL, 49.9 mmol) was slowly added to a mixed solution containing commercially available 2-amino-5-methylbenzamide (5.00 g, 33.3 mmol) and trimethyl orthoformate (51.0 mL, 466 mmol) at 0 °C. The reaction mixture was stirred continuously for 2 hours at room temperature. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue obtained was diluted with distilled water and neutralized with 2 M aqueous sodium hydroxide solution to neutral. Subsequently, the precipitated solid product was collected by filtration and washed sequentially with distilled water, methanol, and ether to finally obtain 6-methyl-4-hydroxyquinazoline (15) as a white powdery solid (4.33 g, 81% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 2.44 (3H, s), 7.57 (1H, d, J = 8.4 Hz), 7.62-7.66 (1H, m), 7.91-7.93 (1H, m), 8.03 (1H, s), 12.2 (1H, bs). | | References | [1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 19, p. 5487 - 5505
[2] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 4, p. 545 - 548
[3] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 3, p. 383 - 391 |
| | 4-HYDROXY-6-METHYLQUINAZOLINE Preparation Products And Raw materials |
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