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Energy Chemical |
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5,15-Diphenyl-21H,23H-porphine manufacturers
- 5,15-DPP
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- $38.00
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2026-07-15
- CAS:22112-89-6
- Purity:
- Supply Ability: 10g
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| | 5,15-Diphenyl-21H,23H-porphine Basic information | | Uses |
| Product Name: | 5,15-Diphenyl-21H,23H-porphine | | Synonyms: | 5,15-DIPHENYLPORPHINE;5, 15-BIS-(PHENYL)PORPHYRINS;5,15-Diphenylporphyrin;STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem;10,20-diphenyl-21,22-dihydroporphyrin;5,15-Bis-(phenyl)-21H,23H-porphyrins;5,15-DPP;Stat3 Inhibitor VIII, 5,15-DPP | | CAS: | 22112-89-6 | | MF: | C32H22N4 | | MW: | 462.54 | | EINECS: | | | Product Categories: | Biochemistry;Porphyrins | | Mol File: | 22112-89-6.mol |  |
| | 5,15-Diphenyl-21H,23H-porphine Chemical Properties |
| Melting point | >200℃ | | Boiling point | 912.3±65.0 °C(Predicted) | | density | 1.285±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | ≤2mg/ml in dimethyl formamide | | form | Deep blue to deep purple solid | | color | Red to Dark blue to Black |
| WGK Germany | 3 | | HS Code | 2933.99.8290 | | HazardClass | IRRITANT | | Storage Class | 11 - Combustible Solids |
| | 5,15-Diphenyl-21H,23H-porphine Usage And Synthesis |
| Uses | 5,15-Diphenylporphyrin (cas# 22112-89-6) is a useful research chemical. | | Uses | 5, 15-DPP has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:
- to analyze its effects on malignant peripheral nerve sheath tumor (MPNST) survival and proliferation
- to study its effects on the thymic stromal lymphopoietin (TSLP) modulation of nometastatic gene 23-H1 (NME1 or nm23-H1) expression in human trophoblasts
- to study its effects on 17β-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced M2 polarization in human macrophages and endometrial stromal cells
| | Biological Activity | 5,15-diphenylporphyrin (5,15-dpp) is a selective stat3-sh2 antagonist [1].stat3 is constitutively activated in many human cancers. stat3 functions as a critical mediator of oncogenic signaling through transcriptional activation of genes encoding apoptosis inhibitors, cell-cycle regulators and inducers of angiogenesis [2]. aberrant stat3 activity has been associated with transforming mechanisms induced by oncogenic tyrosine kinases [1]. | | in vitro | 5,15-dpp directly bound to stat3 and antagonized the function of stat3-sh2. 5,15-dpp selectively antagonized stat3-sh2 with an ic50 of 0.28 μm over the other sh2-containing proteins stat1 and grb2[1]. the estimated kd values for the 5,15-dpp binding to stat3 was 880 nm. treatment with 5,15-dpp suppressed the dna binding activity of stat3 in a concentration-dependent manner. 5,15-dpp poorly inhibited stat1 with an ic50 of 10 μm and showed no effect grb2 [1]. | | references | [1] uehara y, mochizuki m, matsuno k, et al. novel high-throughput screening system for identifying stat3–sh2 antagonists[j]. biochemical and biophysical research communications, 2009, 380(3): 627-631.
[2] jing n, tweardy d j. targeting stat3 in cancer therapy[j]. anti-cancer drugs, 2005, 16(6): 601-607. |
| | 5,15-Diphenyl-21H,23H-porphine Preparation Products And Raw materials |
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