- 4-Iodopyridine
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- $1.10 / 1g
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2025-11-18
- CAS:15854-87-2
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons min
- 4-Iodopyridine
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- $0.00 / 1kg
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2025-04-04
- CAS:15854-87-2
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
- 4-iodopyridine
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- $0.00 / 25KG
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2023-04-21
- CAS:15854-87-2
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000
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| | 4-Iodopyridine Basic information |
| | 4-Iodopyridine Chemical Properties |
| Melting point | 94-99 °C | | Boiling point | 212~215℃ | | density | 1.081g/cm3 | | refractive index | 1.5290 | | storage temp. | -20°C | | solubility | soluble in Methanol | | form | Crystals or Powder | | pka | pK1:4.02(＋1) (20°C) | | color | Pale brown to dark green-brown | | Sensitive | Light Sensitive | | BRN | 1594 | | InChI | InChI=1S/C5H4IN/c6-5-1-3-7-4-2-5/h1-4H | | InChIKey | RTLUPHDWSUGAOS-UHFFFAOYSA-N | | SMILES | C1=NC=CC(I)=C1 | | CAS DataBase Reference | 15854-87-2(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-41-37/38-22 | | Safety Statements | 26-36-39 | | WGK Germany | 3 | | Hazard Note | Irritant/Light Sensitive | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Provider | Language |
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ALFA
| English |
| | 4-Iodopyridine Usage And Synthesis |
| Chemical Properties | White to off-white crystals,turns brown on storage | | Uses | 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. | | Synthesis | GENERAL METHODS: [Li(TMP)Zn(tBu)2] 1 was prepared according to literature methods in a 0.4 mmol scale solution of THF. Pyridine (0.032 mL, 0.4 mmol) was added to this solution at 0°C and the resulting light orange colored reaction mixture was allowed to stir for 2 h at room temperature. Subsequently, the reaction was quenched with I2 (508 mg, dissolved in 1 mL THF) and stirring was continued for 1 hour. A 10% Na2S2O3 solution was added until the color of the reaction mixture faded, and then the product was extracted with DCM (3 x 1 mL). The organic extracts were combined, dried with MgSO4 and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography using EtOAc:heptane (20:80→30:70) as eluent to afford 4-iodopyridine (compound 5a) as an off-white solid (42 mg, 50% yield).1H NMR (400 MHz, CDCl3) δ ppm 7.59-7.86 (m, 2H), 8.07-8.44 (m 2H). | | References | [1] Tetrahedron Letters, 2011, vol. 52, # 36, p. 4590 - 4594
[2] Journal of Organic Chemistry, 1984, vol. 49, # 20, p. 3857 - 3859 |
| | 4-Iodopyridine Preparation Products And Raw materials |
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