- 2-Thiopheneacetic acid
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- $10.00 / 1KG
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2026-01-05
- CAS:1918-77-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- 2-Thienylacetic acid
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- $9.00 / 1KG
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2025-09-25
- CAS:1918-77-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- 2-Thiopheneacetic acid
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- $0.00 / 1kg
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2025-06-20
- CAS:1918-77-0
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 20tons
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| | 2-Thiopheneacetic acid Basic information |
| | 2-Thiopheneacetic acid Chemical Properties |
| Melting point | 63-64 °C (lit.) | | Boiling point | 160 °C/22 mmHg (lit.) | | density | 1.365 (estimate) | | refractive index | 1.5300 (estimate) | | Fp | 160°C/22mm | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | pka | 4.23±0.10(Predicted) | | form | Crystalline Powder | | color | Slightly brown to brown | | Water Solubility | Soluble in water, ethanol, ether and carbon tetrachloride. | | BRN | 114551 | | InChI | 1S/C6H6O2S/c7-6(8)4-5-2-1-3-9-5/h1-3H,4H2,(H,7,8) | | InChIKey | SMJRBWINMFUUDS-UHFFFAOYSA-N | | SMILES | OC(=O)Cc1cccs1 | | CAS DataBase Reference | 1918-77-0(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Thiopheneacetic acid(1918-77-0) | | EPA Substance Registry System | 2-Thiopheneacetic acid (1918-77-0) |
| Hazard Codes | C,Xi | | Risk Statements | 34-37-36/37/38 | | Safety Statements | 26-36/37/39-45-24/25-27 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | Hazard Note | Irritant | | TSCA | TSCA listed | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29349990 | | Storage Class | 11 - Combustible Solids |
| | 2-Thiopheneacetic acid Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powder | | Uses | 2-Thiopheneacetic acid is used in the preparation of rosette-like nanoscale gold materials. Further, it is used as a pharmaceutical intermediate for cefaloridine and cefalotin sodium. | | Definition | ChEBI: 2-thienylacetic acid is a thiophene compound having a carboxymethyl group at the 2-position. It has a role as an allergen. It is a member of thiophenes and a monocarboxylic acid. It is functionally related to an acetic acid. It is a conjugate acid of a thien-2-ylacetate. | | Synthesis Reference(s) | Canadian Journal of Chemistry, 46, p. 1057, 1968 DOI: 10.1139/v68-179
Journal of the American Chemical Society, 72, p. 4326, 1950 | | General Description | Adsorption of 2-thiopheneacetic acid on XAD-4, NDA-100 and ND-90 resin has been investigated. A new polymeric complex of Cu(II) and 2-thiopheneacetic acid has been synthesized and characterized by IR and Raman spectroscopy. | | Synthesis | Steps for the synthesis of 2-thiophene acetic acid: 1 g of ethyl 2-(thiophen-2-yl)acetate was dissolved in 4 mL of ethanol, 8 mL of 4N NaOH aqueous solution was added, and the reaction was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction mixture was adjusted to pH 1 with 1N HCl aqueous solution and subsequently extracted with dichloromethane. The organic phase was separated and concentrated under reduced pressure to remove the solvent to give the oily product 2-thiopheneacetic acid. The yield was close to quantitative.ESI-MS m/z: 141.0 [M-H]? | | Purification Methods | Crystallise the acid from ligroin, hexane and/or distil it in a vacuum. The amide has m 148o (from H2O or pet ether). [Beilstein 18 H 293, 18 III/IV 4062, 18/6 V 207.] | | References | [1] Patent: EP2848617, 2015, A1. Location in patent: Paragraph 0243; 0244
[2] Patent: US2015/141419, 2015, A1. Location in patent: Paragraph 0303; 0304
[3] Journal of Organic Chemistry, 1958, vol. 23, p. 1289,1290 |
| | 2-Thiopheneacetic acid Preparation Products And Raw materials |
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