Biotin-PEG2-C4-Alkyne manufacturers
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| | Biotin-PEG2-C4-Alkyne Basic information |
| Product Name: | Biotin-PEG2-C4-Alkyne | | Synonyms: | Biotin-PEG2-C4-Alkyne;1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-[2-[2-[2-[(1-oxo-5-hexyn-1-yl)amino]ethoxy]ethoxy]ethyl]-, (3aS,4S,6aR)-;Biotin-PEG2-C4-Propargy | | CAS: | 1011268-28-2 | | MF: | C22H36N4O5S | | MW: | 468.61 | | EINECS: | | | Product Categories: | | | Mol File: | 1011268-28-2.mol |  |
| | Biotin-PEG2-C4-Alkyne Chemical Properties |
| Boiling point | 799.8±60.0 °C(Predicted) | | density | 1.158±0.06 g/cm3(Predicted) | | solubility | Soluble in DMSO, DMF | | form | A crystalline solid | | pka | 13.90±0.40(Predicted) |
| | Biotin-PEG2-C4-Alkyne Usage And Synthesis |
| Description | Alkynyl-biotin is a form of biotin with a terminal alkyne group separated by two polyethylene glycol moieties. It is used to add biotin to other molecules bearing an azide group using a copper Cu(I)-catalyzed azide-alkyne cycloaddition reaction. Alkynyl-biotin has been used to add a biotin tag to a range of biochemicals, amino acids, proteins, and nucleotides that have been modified by the addition of an azide group. Alkynyl-biotin can also be used to capture sulfenic acid-modified proteins that have been tagged with the cell-permeable probe DAz-2 . | | Uses | Biotin-PEG2-C4-alkyne is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Biotin-PEG2-C4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] DANIEL B. MCCLATCHY, *. Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice[J]. Journal of Proteome Research, 2015, 14 11: 4815-4822. DOI: 10.1021/acs.jproteome.5b00653
[2] PENG WU. A high-throughput-compatible assay to measure the degradation of endogenous Huntingtin proteins[J]. Acta Pharmacologica Sinica, 2016, 37 10: 1307-1314. DOI: 10.1038/aps.2016.31
[3] JESSICA ZAYAS. Strain Promoted Click Chemistry of 2- or 8-Azidopurine and 5-Azidopyrimidine Nucleosides and 8-Azidoadenosine Triphosphate with Cyclooctynes. Application to Living Cell Fluorescent Imaging[J]. Bioconjugate Chemistry Bioconjugate, 2015, 26 8: 1519-1532. DOI: 10.1021/acs.bioconjchem.5b00300
[4] STEPHEN E. LEONARD Kate S C Khalilah G Reddie. Mining the Thiol Proteome for Sulfenic Acid Modifications Reveals New Targets for Oxidation in Cells[J]. ACS Chemical Biology, 2009, 4 9: 783-799. DOI: 10.1021/cb900105q |
| | Biotin-PEG2-C4-Alkyne Preparation Products And Raw materials |
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