Methylamino-PEG3-azide manufacturers
|
| | Methylamino-PEG3-azide Basic information |
| Product Name: | Methylamino-PEG3-azide | | Synonyms: | Methylamino-PEG3-azide;N3-PEG3-CH2CH2NHMe;Methylamino-PEG3-N3;N3-PEG3-CH2CH2NHMe/Ethanamine, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-N-methyl-;N3-PEG3-NH-Me;MethylNH2-PEG3-N3 | | CAS: | 1355197-57-7 | | MF: | C9H20N4O3 | | MW: | 232.28 | | EINECS: | | | Product Categories: | | | Mol File: | 1355197-57-7.mol |  |
| | Methylamino-PEG3-azide Chemical Properties |
| solubility | Soluble in Water, DMSO, DCM, DMF |
| | Methylamino-PEG3-azide Usage And Synthesis |
| Description | Methylamino-PEG3-azide is a PEG linker containing an azide group with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc. | | Uses | Methylamino-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methylamino-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Methylamino-PEG3-azide Preparation Products And Raw materials |
|